Results 91 to 100 of about 34,622 (239)

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, Volume 20, Issue 16, August 16, 2025.
Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Studies on Synthesis of Pyrimidine Derivatives and their Pharmacological Evaluation

E-Journal of Chemistry, 2007
1,3,4-Oxadiazoles were associated with broad spectrum of biological activities including antituberculosis, anticonvulsant, anti-inflammatory, insecticidal, antifungal, analgesic and antitumor properties. Morpholine derivatives find their wide spectrum of
T. A. Naik, K. H. Chikhalia
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Novel 5-Substituted-2-(3,4,5-trihydroxyphenyl)-1,3,4-oxadiazoles as Potent Antioxidants

, 2016
A novel series of 5-(5-substituted-1,3,4-oxadiazol-2-yl)benzene-1,2,3-triols (3n-z) was designed, synthesized, and evaluated for its potential antioxidant activities.
A. M. Rabie, Atif S. Tantawy, Sahar M. I. Badr   +2 more
semanticscholar   +1 more source

Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.
This review highlights recent advances in mechanochemical methods for multistep organic synthesis, focusing on sequential one‐pot approaches performed by grinding or ball milling. The presented transformations are discussed in terms of efficiency, applicability, and sustainability, assessing both the challenges and potential of solvent‐free one‐pot ...
Nina Biedermann, Michael Schnürch
wiley   +1 more source

Synthesis under Microwave Irradiation of [1,2,4]Triazolo[3,4-b] [1,3,4]thiadiazoles and Other Diazoles Bearing Indole Moieties and Their Antimicrobial Evaluation

Molecules, 2011
Microwave-assisted synthesis of some novel compounds, namely, 3-(2-methyl-1H-indol-3-yl)-6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 5a,b was accomplished via bromination of 2-methyl-3-[4-(arylideneamino)-5-mercapto-4H-[1,2,4]triazol-3-yl]-1H ...
Sobhi M. Gomha, Sayed M. Riyadh
doaj   +1 more source

β‐Lactam Ylidenes: An Overlooked Class of N‐Heterocyclic Carbenes

Chemistry – A European Journal, Volume 31, Issue 31, June 3, 2025.
A highly modular synthetic approach toward four‐membered β‐lactam carbenes (BLCs) is presented. BLCs feature moderate σ‐donor and strong π‐acceptor character, leading to a pronounced ambiphilic reactivity which includes the formation of olefinic dimers as well as unprecedented N2‐bridged dimers, oxirane formation with acetone, and fragmentation to ...
Leonard Karl, Daniel Deißenbeck, Jan Meisner, Christian Ganter   +3 more
wiley   +1 more source

Synthesis, Characterization and study biologicalactivity of several 1-cyclopentene-1,2-dicarboxylimidyl Containing oxadiazole and Benzothiazole

مجلة بغداد للعلوم, 2014
In this work involved prepared of several new 1-cyclopentene-1,2-dicarboxylimide linked to oxadiazole and benzothiazole moiety were synthesized by two steps: The first step 2-amino-substituted-1,3,4-oxadiazoles and substituted-2-aminobenzothiazole were ...
Baghdad Science Journal
doaj   +1 more source

Synthesis and Biological Assessment of Cyanopyridine‐Based 1,3,4‐Oxadiazole Derivatives: Anticancer Potential, Antioxidant Activity, Molecular Docking, and DFT Calculations

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.
A series of novel cyanopyridine‐based 1,3,4‐oxadiazole derivatives were synthesized, and their anticancer activities against the MCF‐7 and CaCo‐2 cancer cell lines, as well as their antioxidant capacities, were evaluated under In Vitro conditions. Furthermore, computational studies utilizing Density Functional Theory (DFT) and molecular modeling were ...
Zineddine Zebbiche, Güldeniz Şekerci, Boulebd Houssem, Fatümetüzzehra Küçükbay, Suat Tekin, Hasan Küçükbay, Boudjemaa Boumoud   +6 more
wiley   +1 more source

Síntese de ligantes fotoluminescentes derivados do heterociclo 1,3,4-oxadiazol [PDF]

, 2005
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Físicas e Matemáticas. Curso de Química.A síntese, de novos compostos fotoluminescentes contendo o heterociclo 1,3,4-oxadiazol são descritas.
FRIZON, Tiago Elias Allievi
core  

Systematic Review on 1,2,3‐Oxadiazoles, 1,2,4‐Oxadiazoles, and 1,2,5‐Oxadiazoles in the Antimycobacterial Drug Discovery

ChemMedChem, Volume 20, Issue 9, May 5, 2025.
The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley   +1 more source