Synthesis and Characterization of Novel 2-Alkyl-1,3,4-Oxadiazoles Containing a Phenylazo Group [PDF]
MoleculesAn efficient method for the synthesis of novel phenylazo-containing moieties is described. The derivatives of 5-(4-(phenyldiazenyl)phenyl)-1,3,4-oxadiazole, substituted at position 2 of the heterocyclic scaffold with alkyl groups of different chain ...
Sebastian Górecki, Agnieszka Kudelko
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Synthesis and antioxidant activity of 1,3,4-oxadiazoles and their diacylhydrazine precursors derived from phenolic acids [PDF]
, 2017 Eight 1,3,4-oxadiazole derivatives containing phenolic acid moieties (7a-h) and eight of their diacylhydrazine precursors (6a-h) were synthesized, characterized using spectroscopic methods and examined by scavenging of stable DPPH (2,2-diphenyl-1 ...
Joksović, Ljubinka +6 more
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1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction. [PDF]
Org Lett, 2019 Easy to perform, functional group tolerant, and short syntheses of the privileged scaffold oxadiazole are highly desired. Here, a metal-free protocol for MCR-based synthesis of 2,5-disubstituted 1,3,4-oxadiazoles via a Ugi-tetrazole/Huisgen sequence was ...
Wang Q +4 more
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Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles. [PDF]
RSC Adv, 2019 A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic attack with acylhydrazides.
Aksenov AV +6 more
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Batch Versus Flow Lithiation-Substitution of 1,3,4-Oxadiazoles: Exploitation of Unstable Intermediates Using Flow Chemistry [PDF]
Chemistry, 2019 1,3,4-Oxadiazoles are a common motif in pharmaceutical chemistry, but few convenient methods for their modification exist. A fast, convenient, high yielding and general α-substitution of 1,3,4-oxadiazoles has been developed using a metalation ...
Barker, Graeme +3 more
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Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents [PDF]
Acta Pharmaceutica, 2019 In an attempt to produce heterocyclic compounds based on 1,3,4-oxadiazole derivatives with potential antiviral activity, the synthesis of compound 1 [2-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetonitrile] was performed through the reaction of ...
HASSAN AHMED ALHAZMI +2 more
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A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions. [PDF]
Chem Sci, 2017 An innovative new synthesis approach to disubstituted 1,3,4-oxadiazoles is described, inspired by Umpolung Amide Synthesis (UmAS).
Tokumaru K, Johnston JN.
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Molecular Structure, Matrix-Isolation IR Spectrum and UV-Induced Transformations of 2-Amino-5-(4-Methoxyphenyl)-1,3,4-Oxadiazole [PDF]
MoleculesThe photochemistry of 1,3,4-oxadiazoles remains poorly understood, despite their recognized importance in medicinal chemistry and materials science. In this work, we report a detailed matrix-isolation study of 2-amino-5-(4-methoxyphenyl)-1,3,4-oxadiazole,
İsa Sıdır +3 more
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Molecular Docking and In Vitro Studies of Synthesized Oxadiazole Derivatives as Urease Inhibitors [PDF]
Journal of Mathematical and Fundamental SciencesA novel sequence of 1,3,4-oxadiazoles (7a–h) was synthesized. The compounds were characterized by IR, ¹H NMR, and MS analyses. They were also examined to determine whether they could prevent urease from functioning.
Kamran Mehdi +7 more
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Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications. [PDF]
Acc Chem Res, 2016 Sears JE, Boger DL.
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