Results 161 to 170 of about 14,599 (204)

1,3,4‐Thiadiazoles

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
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1,3,4-Thiadiazole: A Versatile Pharmacophore of Medicinal Significance

Medicinal Chemistry, 2023
Abstract: The 1,3,4-thiadiazole nucleus has attracted the attention of medicinal chemists during the last decades due to its multiple pharmacological activities, such as antiviral, anticancer, antibacterial, and anticonvulsant activity. This scaffold's structural alteration could aid in developing novel therapeutically effective drugs.
Madhu, Bala, Poonam, Piplani, Amardeep, Ankalgi, Ankit, Jain, Lalit, Chandel   +4 more
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Syntheses of arylsulfonyl‐1,3,4‐thiadiazoles

Journal of Heterocyclic Chemistry, 1996
AbstractReaction of sodium arylsulfinate with 2‐aryl‐5‐chloro‐1,3,4‐thiadiazole gave 2‐aryl‐5‐arylsulfonyl‐1,3,4‐thiadiazole (3) in good yield. Starting from readily available 2‐amino‐5‐benzylmercapto‐1,3,4‐thiadiazole compound 7 was obtained in three steps in moderate yield.
A. Shafiee, A. Foroumadi
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1,3,4-THIADIAZOLES FROM THIOSEMICARBAZIDES

Phosphorus, Sulfur, and Silicon and the Related Elements, 1991
Abstract A new method for the synthesis of 1,3,4-thiadiazoles is described. Thus condensation of 4-methyl-4phenyl-3-thiosemicarbazide with an aldehyde or ketone affords 1,1-disubstituted-6-[1-(arylethylidine) amino] −2,5-dithiobiureas, rather than the anticipated 4,4-disubstituted-3-thiosemicarbazones.
John P. Scovill, Daniel L. Klayman, Judith L. Flippen-anderson, Richard Gilardi   +3 more
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Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles

European Journal of Medicinal Chemistry, 2009
A new class of 1,3,4-oxadiazoles were prepared from acid hydrazides on treatment with different carboxylic acids in the presence of phosphorus oxychloride.
Padmaja Adivireddy, P Kondaiah, V Padmavathi   +2 more
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1,3,4-Thiadiazole Based Anticancer Agents

Anti-Cancer Agents in Medicinal Chemistry, 2016
In recent years, researchers like medicinal chemists in the field of medicinal chemistry have widely utilized the 1,3,4-thiadiazole nucleus to investigate its biological and pharmacological effects. This heterocyclic structure has demonstrated various bioactivities such as antifungal, antimicrobial, antiviral, antileishmanial, anti-inflammatory ...
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2-Amino-5-methyl-1,3,4-thiadiazole and 2-amino-5-ethyl-1,3,4-thiadiazole

Acta Crystallographica Section C Crystal Structure Communications, 2001
The structures of 2-amino-5-methyl-1,3,4-thiadiazole, C(3)H(5)N(3)S, and 2-amino-5-ethyl-1,3,4-thiadiazole, C(4)H(7)N(3)S, have been determined for comparison with unsubstituted 2-amino-1,3,4-thiadiazole. Despite their different space groups (P2(1)/n and Pbca, respectively), the packing modes of the methyl and ethyl derivatives are similar, with ...
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Synthesis of 1,3,4‐Thiadiazoles from Aldehyde Hydrazones.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Kentaro Okuma, Kazuko Nagakura, Yasutaka Nakajima, Kento Kubo, Kosei Shioji   +4 more
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Synthesis of Substituted 1,2,4-Triazoles and 1,3,4-Thiadiazoles

Chemistry of Heterocyclic Compounds, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
T. R. Hovsepian, E. R. Dilanian, A. P. Engoyan, R. G. Melik‐Ohanjanian   +3 more
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Recent Advances in the Chemistry of 1,3,4-Thiadiazoles

1968
Publisher Summary This chapter discusses homologs, functional groups, physical properties, and the uses of 1, 3, 4-thiadiazole. The development of 1, 3, 5- thiadiazole chemistry is linked to the discovery of phenylhydrazine and hydrazine. The numbering of the 1, 3, 4-thiadiazole ring follows from 1.
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