Results 71 to 80 of about 3,168 (197)

In Vitro and In Silico Evaluation of Isatin‐Derived Spirooxindoles as Antituberculosis Drug Candidates

Chemical Biology &Drug Design, Volume 106, Issue 1, July 2025.
Two compounds, A16 and A17, were active against multidrug‐resistant Mycobacterium tuberculosis isolates (PT‐12 and PT‐20), overcoming key resistance mutations in katG and rpoB, while cytotoxicity assays confirmed that they are non‐toxic. A17 exhibited the highest antituberculosis activity, with molecular docking suggesting enoyl‐[acyl‐carrier‐protein ...
Fernanda Rodrigues de Lima, Jéssika de Oliveira Viana, Aleff Cruz de Castro, Rodrigo Cristiano, Marcia Alberton Perelló, Alexia de Matos Czeczot, Cristiano Valim Bizarro, Pablo Machado, Luiz Augusto Basso, Claudio Gabriel Lima‐Junior, Valnês da Silva Rodrigues‐Junior, Karen Cacilda Weber   +11 more
wiley   +1 more source

Systematic Review on 1,2,3‐Oxadiazoles, 1,2,4‐Oxadiazoles, and 1,2,5‐Oxadiazoles in the Antimycobacterial Drug Discovery

ChemMedChem, Volume 20, Issue 9, May 5, 2025.
The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley   +1 more source

Newly synthesized Bis-Hydrazono[1,3,4] thiadiazoles as Anti-Alzheimer’s Agents: Greener past and In-Vitro acetylcholinesterase inhibition assay investigations

Journal of Saudi Chemical Society
The designed and synthesized multifunctional properties of bis-hydrazono[1,3,4]thiadiazoles became important for developing an efficient medication for Alzheimer’s disease.
Reem A.K. Alharbi, Sayed M. Riyadh, Nadia S. Al-Kaff, Musa A. Said   +3 more
doaj   +1 more source

NEW DERIVATIVES OF 2-R1-N-(5-R)-1,3,4-THIADIAZOL-2-YL-BENZOLSULFONAMIDES: SYNTHESIS, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY PREDICTION [PDF]

Annals of Mechnikov's Institute, 2015
Introduction: The analysis of modern literature, including overseas one, showed that a lot of the scientific researches is devoted to finding and creating biologically active compounds on base 1,3,4-thiadiazole.
Sych I.V., Perekhoda L.О., Іеremina Z.G.   +2 more
doaj  

Developmental impact of joint forest planning and management (JFPM) programme on forest dependent communities: experiences from joida, Karnataka [PDF]

, 2017
Joint Forest Planning and Management Programme was introduced in the state of Karnataka in the year 1993. A product of the National Forest Policy of 1988, JFPM was an effort in the direction of involving local communities in the management of forest ...
Derekar, Jayanand Hambeer
core  

New resource-efficient and green synthesis methods for biologically active derivatives of urea [PDF]

, 2017
Developed were highly effective solvent-free processes for preparation of substituted ureas containingpharmacophore substituents (benzhydryl ureas, dihydroquinazolinones, semicarbazones, thiosemicarbazonesand guanylhydrazones), consistent with green ...
Filimonov, Viktor Dmitrievich, Kuksenok, Vera Yurievna, Shtrykova, Viktoriya Viktorovna, Sidel’nikova, S. P.   +3 more
core   +2 more sources

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, Volume 15, Issue 5, Page 773-792, May 2025.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Synthesis of 5-substituted 1,3,4-thiadiazol-2-yl-sulfanylacetic acid derivatives [PDF]

, 2016
The study is devoted to the design and synthesis of new 2,5-disubstituted 1,3,4-thiadiazoles 3a-k as a promising multi-targeted pharmacological scaffold. Heterocyclization of acylated thiosemicarbazides 1a-i with carbon disulfide lead to the intermediate
Perekhoda, Lina, Sych, Igor, Tsapko, Tetiana   +2 more
core   +2 more sources

Ultrasound assisted synthesis of some new 1,3,4-thiadiazole and bi(1,3,4-thiadiazole) derivatives incorporating pyrazolone moiety

Ultrasonics Sonochemistry, 2009
Novel substituted 1,3,4-thiadiazole and bi(1,3,4-thiadiazole) were synthesized from reaction of 1-methyl-5-oxo-3-phenyl-2-pyrazolin-4-thiocarbox-anilide with a series of different hydrazonyl halides or N,N'-diphenyl-oxalodihydrazonoyl dichloride. The reactions were carried out under both conventional and ultrasonic irradiation conditions.
Naglaa M, Abd El-Rahman, Tamer S, Saleh, Mohamed F, Mady   +2 more
openaire   +2 more sources

Selective Toluene Oxidation Using Sulfur‐Doped Polymeric Carbon Nitride Photocatalysts

Small, Volume 21, Issue 20, May 19, 2025.
The design and utilization of sulfur‐doped polymeric carbon nitride (S‐CN) as a versatile photocatalyst for selective toluene oxidation, applicable in powder form and as binder‐free panels across various reactor configurations and solvents, are shown. The optimized photocatalyst achieves high activity and product selectivity to benzaldehyde or benzoic ...
Bayan Abed, Venugopala Rao Battula, Michael Volokh, Devesh Garg, Tirza Shmila, Gabriel Mark, Ayelet Tashakory, Alexander I. Shames, Menny Shalom   +8 more
wiley   +1 more source