Results 71 to 80 of about 1,311 (155)

Synthesis of some new pyrazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine, 1,3,4-thiadiazole and pyridine derivatives containing 1,2,3-triazole moiety

Chemistry Central Journal, 2017
Background Pyrazolo[1,5-a]pyrimidines are purine analogues. They have beneficial properties as antimetabolites in purine biochemical reactions. This division compounds have attracted wide pharmaceutical interest because of their antitrypanosomal activity.
Nadia A. Abdelriheem, Yasser H. Zaki, Abdou O. Abdelhamid   +2 more
doaj   +1 more source

3-(2-Fluorophenyl)-6-(phenoxymethyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

Acta Crystallographica Section E, 2008
The crystal structure of the title compound, C16H11FN4OS, was synthesized in the course of our studies on 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles as inhibitors of p38 mitogen-activated protein kinase (MAPK). The three-dimensional data obtained were used
Stefan Laufer, Dieter Schollmeyer, Melanie Holm   +2 more
doaj   +1 more source

2-Amino-5-propyl-1,3,4-thiadiazole

Acta Crystallographica Section E Structure Reports Online, 2002
The title compound, C5H9N3S, which exhibits a hypoglycemic effect, crystallizes in space group P21/c. The structure is held together by a network of intermolecular N—H⋯N hydrogen bonds.
Choudhury, Angshuman Roy, Mruthyunjayaswamy, BHM, Ijare, Omkar B, Jadegoud, Y, Row, Guru TN   +4 more
openaire   +2 more sources

Synthesis and Anticancer Activity of 1,3,4-Thiadiazoles with 3-Methoxyphenyl Substituent. [PDF]

Molecules, 2022
Janowska S, Khylyuk D, Gornowicz A, Bielawska A, Janowski M, Czarnomysy R, Bielawski K, Wujec M.   +7 more
europepmc   +1 more source

5,5′-Dimethyl-2,2′-dithiodi-1,3,4-thiadiazole

Acta Crystallographica Section E Structure Reports Online, 2002
The title compound, C6H6N4S4, is formed through the thionato S—S bonding of parent 2-mercapto-5-methyl-1,3,4-thia­diazole mol­ecules, following the deprotonation of thiol groups in a mixed solvent. The title compound crystallizes in the monoclinic system, space group C2/c. The S—S distance is 2.028 (1) A, typical of a single bond.
Jun-Ling Song, Wen-Bo Zhou, Hui-Yi Zeng, Zhen-Chao Dong   +3 more
openaire   +1 more source

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

BMC Cancer, 2017
Background Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer ...
C. P. Baburajeev, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Daniel J. Mason, Julian E. Fuchs, Andreas Bender, Uri Barash, Israel Vlodavsky, Basappa, Kanchugarakoppal S. Rangappa   +9 more
doaj   +1 more source

Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E₂ and Leukotriene Biosynthesis Inhibitors. [PDF]

ACS Med Chem Lett, 2023
Potenza M, Giordano A, Chini MG, Saviano A, Kretzer C, Raucci F, Russo M, Lauro G, Terracciano S, Bruno I, Iorizzi M, Hofstetter RK, Pace S, Maione F, Werz O, Bifulco G.   +15 more
europepmc   +1 more source

Design, Synthesis, Antibacterial Evaluations and In Silico Studies of Novel Thiosemicarbazides and 1,3,4-Thiadiazoles. [PDF]

Molecules, 2022
Janowska S, Khylyuk D, Andrzejczuk S, Wujec M.   +3 more
europepmc   +1 more source

New 1,3,4-thiadiazoles as potential anticancer agents: pro-apoptotic, cell cycle arrest, molecular modelling, and ADMET profile. [PDF]

RSC Adv, 2023
Hekal MH, Farag PS, Hemdan MM, El-Sayed AA, Hassaballah AI, El-Sayed WM.   +5 more
europepmc   +1 more source

Exploring the Antiparasitic Activity of Tris-1,3,4-Thiadiazoles against Toxoplasma gondii-Infected Mice. [PDF]

Molecules, 2022
Almutairi TM, Rezki N, Aouad MR, Hagar M, Bakr BA, Hamed MT, Hassen MK, Elwakil BH, Moneer EA.   +8 more
europepmc   +1 more source