Studies in Thiadiazoles: Part VI. Synthesis of some 2-Substituted-5-Mercapto-1,3,4-Thiadiazoles and Related Compounds [PDF]
, 1967 Several 2-substituted-5-mercapto-1,3,4-thiadiazoles have been synthesised. Their sodium salts have been condensed with appropriate alkyl and aralkyl halides and the resultant sulphides oxidised to corresponding sulphones.
S. Giri, H. Singh
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Recent synthetic strategies of medicinally important imidazothiadiazoles
Journal of Saudi Chemical Society, 2023 Imidazothiadiazole is a fundamental fused heterocyclic compound containing imidazole and thiadiazole ring systems. This versatile framework has significant applications in pharmaceutical chemistry and also possessed a remarkable biological profile.
Tooba Jabeen +6 more
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Synthesis and antituberculosis activity of 2-(aryl/alkylamino)-5-(4- aminophenyl)-1,3,4-thiadiazoles and their Schiff bases [PDF]
, 2006 A series of new Schiff bases were synthesized through the condensation reaction of 1,3,4-thiadiazoles containing a aromatic primary amine and 3-hydroxybenzaldehyde, salicylaldehyde, 5-nitrofurfuraldehyde or 3-nitrobenzaldehyde.
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Molecules, 2017 Synthesis and characterization of new thiadiazoles, bisthiadiazoles from the reaction of mono- and di-hydrazonoyl halides with various hydrazinecarbodithioate derivatives were studied.
Abdelwahed R. Sayed, Shar Saad Al-Shihry
doaj +1 more source
Journal of Pharmacopuncture, 2021 Objectives: Pathogenic microbes are causal agents for various types of severe and even lethal infectious diseases. Despite of development in medication, bacterial and fungal infections still persist to be a vital problem in health care.
Sagar Sahu +3 more
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Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor
Bulletin of the Korean Chemical Society, EarlyView.This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim +8 more
wiley +1 more source
Synthesis and antioxidant activity of styryl-1,3,4-thiadiazoles, pyrazolyl-1,3,4-thiadiazoles and isoxazolyl-1,3,4-thiadiazoles [PDF]
, 2017 325-333A new class of sulfonamido methyl linked styrylsulfonylmethyl-1,3,4-thiadiazoles, pyrazolyl and isoxazolyl 1,3,4-thiadiazoles have been synthesized from the synthetic intermediate 2-(arylaminosulfonylmethyl)-5- (Z-(styrylsulfonylmethyl))-1,3,4 ...
Padmavathi, V +5 more
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Synthesis of coumarin appended pyrazolyl-1,3,4-oxadiazoles and pyrazolyl-1,3,4-thiadiazoles: Evaluation of their in vitro antimicrobial and antioxidant activities and molecular docking studies [PDF]
, 2017 A series of semicarbazones, thiocarbazones, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles bearing coumarin and pyrazole moiety have been synthesized. The new synthesized compounds were screened in vitro for their antimicrobial and antioxidant activities ...
G. Pavithra +7 more
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Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Síntese e caracterização de novos materiais funcionais contendo 1,2,4-oxadiazol, 1,3,4-oxadiazol e 1,2,3-triazol [PDF]
, 2014 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2014Neste trabalho de tese de doutorado são apresentadas as sínteses ecaracterizações de três novas ...
Girotto, Edivandro
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