Results 51 to 60 of about 14,599 (204)

Recent synthetic strategies of medicinally important imidazothiadiazoles

Journal of Saudi Chemical Society, 2023
Imidazothiadiazole is a fundamental fused heterocyclic compound containing imidazole and thiadiazole ring systems. This versatile framework has significant applications in pharmaceutical chemistry and also possessed a remarkable biological profile.
Tooba Jabeen, Sana Aslam, Muhammad Yaseen, Muhammad Jawwad Saif, Matloob Ahmad, Sami A. Al-Hussain, Magdi E.A. Zaki   +6 more
doaj   +1 more source

Synthesis and Evaluation of Antimicrobial Activity of 1, 3, 4-Thiadiazole Analogues for Potential Scaffold

Journal of Pharmacopuncture, 2021
Objectives: Pathogenic microbes are causal agents for various types of severe and even lethal infectious diseases. Despite of development in medication, bacterial and fungal infections still persist to be a vital problem in health care.
Sagar Sahu, Tanesh Sahu, Gunjan Kalyani, Bina Gidwani   +3 more
doaj   +1 more source

Heterocyclic‐Based Fungicides: Emerging Strategies for Viable Plant Disease Control

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Heterocyclic compounds have attracted considerable attention because of their structural diversity, potent antifungal activity, and ability to interact with multiple fungal targets, offering broad‐spectrum protection against phytopathogens. Synthetic and semisynthetic/part‐natural scaffolds, particularly azole, quinoline, indole, cyclotryptamine, and ...
Sumit Tahlan, Meenakshi Kaira, Sucheta Singh, Hrithik Dey, Kailash C. Pandey   +4 more
wiley   +1 more source

Synthesis and Antimicrobial Activity of New 5-(2-Thienyl)-1,2,4-triazoles and 5-(2-Thienyl)-1,3,4-oxadiazoles and Related Derivatives

Molecules, 2010
New 5-(2-thienyl)-1,2,4-triazoles and 5-(2-thienyl)-1,3,4-oxadiazoles namely, N-[3-mercapto-5-(2-thienyl)-1,2,4-triazol-4-yl]-N'-arylthioureas 4a–e, 2-arylamino-5-(2-thienyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles 5a–e, 3-arylaminomethyl-5-(2-thienyl ...
Mohamed A. Al-Omar
doaj   +1 more source

Azodicarboxylates: valuable reagents for the multicomponent synthesis of novel 1,3,4-thiadiazoles and imidazo[2,1-b][1,3,4]thiadiazoles

, 2013
Summarization: Upon reaction of 4,5-disubstituted-N-arylaminoimidazole-2-thiones with isocyanides in the presence of azodicarboxylates (1.2 equiv) at rt, the imidazo[2,1-b][1,3,4]thiadiazoles were formed as the only reaction products in very good yields,
Gernot Buth, Buth, G., Neochoritis, C. G., Zarganes-Tzitzikas, T., Julia Stephanidou-Stephanatou, Κωστακης Γεωργιος(http://users.isc.tuc.gr/~gkostakis), Tsoleridis, C. A., Constantinos A. Tsoleridis, Tryfon Zarganes-Tzitzikas, Stephanidou-Stephanatou, J., Constantinos G. Neochoritis, Kostakis Georgios(http://users.isc.tuc.gr/~gkostakis), Kostakis, G. E.   +12 more
core   +1 more source

Deciphering the Medicinal Chemistry Aspects of Akt Inhibitors for the Management of Cancer: Structure–Activity Relationship Frameworks, Landscapes, and Optimization Approaches

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review majorly describes the systematic development of Akt inhibitors involving numerous heterocyclic scaffolds along with their structure activity relationships to explore anticancer therapeutic strategies. ABSTRACT The Akt pathway is dysregulated in cancer, leading to proliferation, decreased apoptosis, and metastasis, and hence is a major ...
Mayur S. Dhangar, Mahesh B. Palkar
wiley   +1 more source

Inherent Stability Challenges of Ultrawide‐Bandgap Halide Perovskite for Multijunction Solar Cells

Small Structures, Volume 7, Issue 9, September 2026.
This graphical abstract illustrates the relationship between the intrinsic instability of ultrawide‐bandgap (UWBG) perovskites for multijunction solar cells and the corresponding stabilization strategies. Composition engineering, interfacial engineering, passivation, and entropy engineering are highlighted as key approaches toward achieving both high ...
Sang Won Kang, Lee Da Seul, Ki Taek Oh, Minwoo Lee, Tommy H. Richards, Wei Zhang, Jae Sung Yun, Jongsung Park   +7 more
wiley   +1 more source

In vıtro Antioxidant Properties of Novel Compound (1R, 2R) -1,2-bis- (5- (4- Hydroxynaphthalen-1-ylazo) - [1,3,4] Thiadiazol-2-YL) -Ethane- 1,2-Diole

Cumhuriyet Science Journal, 2018
1,3,4-Thiadiazoles have a variety of biologicalactivities depending on their substituents. This study aims to investigatethe in vitro antioxidant properties of 1R,2R-1,2-bis- (5- (4-hydroxynaphthalen-1-ylazo) - [1,3,4] thiadiazol-2-yl) -ethane- 1,2-diole
Akif Evren Parlak, Pelin Koparır
doaj   +1 more source

Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles

E-Journal of Chemistry, 2011
In the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles (6a-c).
Bahram Letafat, Negar Mohammadhosseini, Ali Asadipour, Alireza Foroumadi   +3 more
doaj   +1 more source

Novel thiadiazole-thiazole hybrids: synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines

Journal of Taibah University for Science, 2022
One of the worst diseases, cancer claims millions of lives each year throughout the world, necessitating the creation of novel treatments. In this study, we designed a novel series of 1,3,4-thiadiazoles through the reaction of 2-(4-methyl-2-(2-(1 ...
Ghadah F. Aljohani, Tariq Z. Abolibda, Mohammad Alhilal, Jehan Y. Al-Humaidi, Suzan Alhilal, Hoda A. Ahmed, Sobhi M. Gomha   +6 more
doaj   +1 more source