Results 41 to 50 of about 14,599 (204)
1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents [PDF]
Frontiers in Chemistry, 2022 A wide range of biological activities is exhibited by 1,3,4-thiadiazole moiety such as antidiabetic, anticancer, anti-inflammatory, anticonvulsant, antiviral, antihypertensive, and antimicrobial. To date, drugs such as butazolamide, and acetazolamide.
Tulika Anthwal, Sumitra Nain
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[O─I─O]+ Halogen‐Bonded Complexes of Pyridine N‐Oxides
Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.The missing puzzle of 3‐center‐4‐electron halogen‐bonded complexes viz. [O─I─O]+ of pyridine N‐oxides are structurally characterized by x‐ray diffraction. Monodentate N‐oxide O‐atom acts as the halogen bond acceptor. Their solution complexations are characterized by 15N NMR spectroscopy.
Rakesh Puttreddy +3 more
wiley +2 more sources
Synthesis of 1,3,4-Thiadiazole Derivatives and Their Anticancer Evaluation
International Journal of Molecular Sciences, 2023 Thiadiazole derivatives have garnered significant attention in the field of medicinal chemistry due to their diverse pharmacological activities, including anticancer properties. This article presents the synthesis of a series of thiadiazole derivatives and investigates their chemical characterization and potential anticancer effects on various cell ...
Camelia Elena Stecoza +8 more
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Antimicrobial Activity of 1,3,4-Thiadiazole Derivatives. [PDF]
Pharmaceuticals (Basel)The 1,3,4-thiadiazole core has attracted significant attention due to its unique electronic structure, physicochemical properties, and wide-ranging pharmacological potential. This heterocyclic scaffold exhibits a broad spectrum of biological activities, often attributed to its capacity to modulate enzyme function, interact with receptors, and disrupt ...
Górecki S, Kudelko A, Olesiejuk M.
europepmc +4 more sources
, 2016 A copper-mediated, three-component reaction between two different N-Ts hydrazones and elemental sulfur was developed, leading to a series of unsymmetric 2,5-disubstituted 1,3,4-thiadiazoles in moderate yields with good functional group compatibility ...
Jiangfei Chen (1446982) +4 more
core +1 more source
Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole N-glycosides [PDF]
Molecules, 2019 New 1,3,4-thiadiazole thioglycosides linked to substituted arylidine systems were synthesized via glycosylation of the prepared 1,3,4-thiadiazole thiol compounds. Click strategy was also used for the synthesis of new 1,3,4-thiadiazole and 1,2,3-triazole hybrid glycosides by reaction of the acetylenic derivatives with different glycosyl azids followed ...
Fahad M. Alminderej +4 more
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Síntese e caracterização de novos materiais funcionais contendo 1,2,4-oxadiazol, 1,3,4-oxadiazol e 1,2,3-triazol [PDF]
, 2014 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2014Neste trabalho de tese de doutorado são apresentadas as sínteses ecaracterizações de três novas ...
Girotto, Edivandro
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Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Innovative synthesis of a novel benzothiophene–based bis–oxadiazole derivatives. The structural characterization was performed using experimental and theoretical methods. Significant anticancer activity against selected cancer cell lines. Three derivatives showed good activity 7b, 7g and 7i with IC50 values 7.5 ± 1.04 and 9.5 ± 1.01 µg/mL.
Nagaraju Madala +2 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.Photocycloaddition in stilbene‐type salt polymorphs exhibit distinct light‐driven responses: OHT‐TI shows a violent photosalient effect under visible and NIR (two‐photon) irradiation, whereas OHT‐TII reacts statically. Packing and computational analysis reveals that shell‐like structures in OHT‐TI frustrate structural relaxation, accumulating explosive
Emanuela Santagata +10 more
wiley +2 more sources
Synthesis and antioxidant activity of styryl-1,3,4-thiadiazoles, pyrazolyl-1,3,4-thiadiazoles and isoxazolyl-1,3,4-thiadiazoles [PDF]
, 2017 325-333A new class of sulfonamido methyl linked styrylsulfonylmethyl-1,3,4-thiadiazoles, pyrazolyl and isoxazolyl 1,3,4-thiadiazoles have been synthesized from the synthetic intermediate 2-(arylaminosulfonylmethyl)-5- (Z-(styrylsulfonylmethyl))-1,3,4 ...
Padmavathi, V +5 more
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