Фармацевтичний журнал, 2021 One of the promising methods of creating antitumor drugs is the screening of potential antitumor agents among synthesized compounds. Nitrogen-based heterocycle analogues are an extremely important class of organic substances that are widely used in ...
I. І. Myrko +4 more
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Synthesis and Antifungal Activities of Perillyl Alcohol Based 1,3,4-Thiadiazole-Thioether Compounds. [PDF]
Chem BiodiversA series of perillyl alcohol‐derived 1,3,4‐thiadiazole‐thioether compounds were designed, synthesized, and evaluated for their antifungal activities. Compound V15 was identified as the most potent derivative, demonstrating superior efficacy against G.
Xiong Y +6 more
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Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid Chlorides [PDF]
مجلة التربية والعلم, 2013 The conversion of some acid chlorides to substituted 1,3,4-oxadiazole, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. Benzoyl chloride and 4- nitrobenzoyl chloride were treated with hydrazine hydrate in ethanol to give acid hydrazides (1,2), The ...
E. Q. Mahmood, O. Th. Ali, K. M. Daoud
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Design, Synthesis, and Investigation of the Biological Activities of New Thiadiazole Derivatives With Anticancer Effects. [PDF]
Chem Biol Drug DesIn silico studies reveal that compound 3c interacts strongly with the active site of the aromatase enzyme. In addition, compound 3c yielded promising results in in vitro enzyme inhibition and cytotoxicity studies. ABSTRACT Breast cancer is one of the most significant diseases in today's world.
Özkay Y +5 more
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Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review [PDF]
Molecules, 2020 During recent years, small molecules containing five-member heterocyclic moieties have become the subject of considerable growing interest for designing new antitumor agents. One of them is 1,3,4-thiadiazole. This study is an attempt to collect the 1,3,4-thiadiazole and its derivatives, which can be considered as potential anticancer agents, reported ...
Sara Janowska +2 more
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Synthesis Of 2-Benzamidomethyl-5-Substituted Amino-1,3,4-Thiadiazoles-2,5-Disubstituted 1,3,4-Oxadiazole and 4,5-Disubstituted 1,2,4-Triazole-3-Thiol [PDF]
مجلة التربية والعلم, 2012 In this paper the synthesis of some substituted 1,3,4-oxadiazoles , 1,3,4-thiadiazoles and 1,2,4-triazoles starting from amino acid and benzoyl chloride is reported.
K. M. Daoud, A. N. Ali, A. A. Ahmed
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Synthesis and Study of Some 4-Chlorophenoxy Methyl Substituted amido1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles and 1,2,4-Triazoles from 4-Chloro phenoxy acetic acid [PDF]
مجلة التربية والعلم, 2013 : In this paper the synthesis of some substituted 1,3,4-oxadiazole, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. 4-Chlorophenol was treated with chloroacetic acid to give 4-chlorophenoxy acetic acid (C1) which was reacted with thionyl chloride ...
Mudhar A. Othman, Khalid M. Daoud
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Synthesis of 2- alkyl/phenyl -5-Substituted 1,3,4- Thiadiazoles [PDF]
مجلة التربية والعلم, 2014 In this paper the synthesis of some 2-alkyl phenyl 5-substituted 1,3,4-thiadiazole is reported, Benzonitrile and Acetonitrile were treated with thiosemicarbazide in presence of trifluroacetic acid to give 2-alkyl/ aryl -5- amino- 1,3,4- thiadiazoles (1,2)
Khalid Daoud +2 more
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Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022 Synthesis and structural modification of azoles remains an important area of medical chemistry and allows to obtain new compounds with a wide range of biological activity.
О. V. Kholodniak +2 more
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Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation
Pharmaceutics, 2021 The fusion of 1,2,4-triazole and 1,3,4-thiadiazole rings results in a class of heterocycles compounds with an extensive range of pharmacological properties.
Dimitrios T. Trafalis +8 more
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