Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022 Synthesis and structural modification of azoles remains an important area of medical chemistry and allows to obtain new compounds with a wide range of biological activity.
О. V. Kholodniak +2 more
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Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation
Pharmaceutics, 2021 The fusion of 1,2,4-triazole and 1,3,4-thiadiazole rings results in a class of heterocycles compounds with an extensive range of pharmacological properties.
Dimitrios T. Trafalis +8 more
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Antimicrobial Activity of 1,3,4-Thiadiazole Derivatives. [PDF]
Pharmaceuticals (Basel)The 1,3,4-thiadiazole core has attracted significant attention due to its unique electronic structure, physicochemical properties, and wide-ranging pharmacological potential. This heterocyclic scaffold exhibits a broad spectrum of biological activities, often attributed to its capacity to modulate enzyme function, interact with receptors, and disrupt ...
Górecki S, Kudelko A, Olesiejuk M.
europepmc +4 more sources
Synthesis and Biological Evaluation of Some Newer 1H-Benzo[b][1,5]diazepin-2(3H)-one Derivatives as Potential Anticonvulsant Agents [PDF]
Pharmaceutical Sciences, 2022 Background: Regardless of the availability of all novel and earlier treatments, seizure control is notoriously complicated. In the hopes of discovering the latest and ultimate therapy, medicinal chemists will keep on to hunt for new antiepileptic ...
Dinesh D Rishipathak +2 more
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Multicomponent Coupling Reactions of Two N‑Tosyl Hydrazones and Elemental Sulfur: Selective Denitrogenation Pathway toward Unsymmetric 2,5-Disubstituted 1,3,4-Thiadiazoles [PDF]
, 2016 A copper-mediated, three-component reaction between two different N-Ts hydrazones and elemental sulfur was developed, leading to a series of unsymmetric 2,5-disubstituted 1,3,4-thiadiazoles in moderate yields with good functional group compatibility ...
Jiangfei Chen (1446982) +4 more
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Biological activities of imidazo[2,1-b][1,3,4]thiadiazole derivatives: A review
Journal of Saudi Chemical Society, 2016 Imidazo[2,1-b][1,3,4]thiadiazole heterocycle was discovered during the 1950s. Since then, many newer derivatives are being developed and evaluated for their biological profiles. The derivatives of imidazo[2,1-b][1,3,4]thiadiazoles are widely explored for
Bhoomendra A. Bhongade +3 more
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New 1,3,4-Thiadiazole Derivatives with Anticancer Activity
Molecules, 2022 We designed and synthesized the 1,3,4-thiadiazole derivatives differing in the structure of the substituents in C2 and C5 positions. The cytotoxic activity of the obtained compounds was then determined in biological studies using MCF-7 and MDA-MB-231 breast cancer cells and normal cell line (fibroblasts).
Sara Janowska +8 more
openaire +3 more sources
Molecules, 2011 A new series of thiadiazole-enaminones 4 were synthesized via reactions of 5-acetyl-1,3,4-thiadiazoles 3 with dimethylformamide-dimethylacetal (DMF-DMA).
Thoraya A. Farghaly +2 more
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Recent Developments In Chemistry Of 1,3,4-Thiadiazoles [PDF]
, 2014 The methods of preparation, structure and biological activities of 1,3,4-thiadiazoles are ...
Mahmoud Fawzy Ismail +3 more
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Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017 Introduction. Currently an attempt to combine 1,2,4-triazole heterocycle with various pharmacologically active fragments of other organic molecules is popular among the scientists.
O. A. Bihdan, V. V. Parchenko
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