Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade [PDF]
Molecules, 2022 The bioisosteres of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles are well-known pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1,3,4-oxa-/thiadiazole nuclei have been very attractive to researchers for drug design ...
Rana M. El-Masry +3 more
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Chemoselective synthesis of 1,3,4-thiadiazoles from acyl hydrazines and nitroalkanes using elemental sulfur [PDF]
Nature CommunicationsSubstituted 1,3,4-thiadiazoles find extensive use in pharmaceutical, agricultural, and materials chemistry. The incorporation of adaptable heterocyclic pharmacophores results in tunable hybrid molecules with diverse medicinal properties.
Xiaonan Wang +6 more
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Design, synthesis and biological evaluation of benzoxazolinone-containing 1,3,4-thiadiazoles as TNF-α inhibitors [PDF]
Heliyon, 2019 A library of nineteen benzoxazolinone-based 1,3,4-thiadiazoles has been synthesized and screened for their anti-inflammatory activity. The compound 1f exhibited a potent anti-inflammatory activity with an inhibition of 65.83% and 32.50% after 3 h and 5 h
Saqlain Haider +4 more
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Synthesis and Diuretic Activity of Substituted 1,3,4-Thiadiazoles [PDF]
Scientifica, 2022 1,3,4-Thiadiazole nuclease, a 5-membered heterocyclic ring system containing two nitrogen and one sulfur atoms in addition to carbon atoms, is compound that showed promising results in the process of searching new diuretic agents. In this study, seven 5-
Asrat Ergena +2 more
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Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles [PDF]
Molecules, 2011 2-Amino-5-(2-aryl-2H-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles 2-4 have been synthesized by the reaction of 2-aryl-2H-1,2,3-triazole-4-carboxylic acids 1 with thiosemicarbazide. Their reaction with phenacyl (p-substituted phenacyl) bromides led to formation
Kamal F. M. Atta +3 more
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2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses [PDF]
Acta Pharmaceutica, 2020 Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan ...
Serban Georgeta
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Acute toxicity of 3-(2-, 3-fluorophenyl)-6-(aryl-, hetaryl)-[1,2,4]triazole[3,4-b][1,3,4]thiadiazoles [PDF]
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017 Nowadays an attempt to create a number of new biologically active compounds by many scientific groups is being one of the topical issues in the domestic pharmaceutical industry.
O. A. Bihdan, V. V. Parchenko
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Thiadiazoles. III*. Some 5-Substituted Derivatives of 2-Amino-1,3,4-Thiadiazoles and Some Mesoionic 1,3,4-Thiadiazoles [PDF]
Croatica Chemica Acta, 1971 New derivatives of 1,3,4-thiadiazoles with potential phytohormonic (compds. I-V) and antibacterial (compds. VI-IX) activity have been prepared.
D. Kolbah +3 more
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Iodine/TBAB-promoted oxidative cyclization: an efficient approach to thiadiazoles [PDF]
RSC AdvancesA rapid and efficient method for synthesizing 2-amino-1,3,4-thiadiazoles and 1,2,3-thiadiazoles via the oxidative cyclization of N-tosylhydrazones obtained from aromatic aldehydes and acetophenones has been developed.
Rakshanda Singhal +3 more
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MoleculesA study on the functionalisation of 2-mercapto-5-methyl-1,3,4-thiadiazole has been conducted, yielding two series of products: 2-(ω-haloalkylthio)thiadiazoles and symmetrical bis-thiadiazoles, with variable chain lengths. The experimental conditions were
Zhanina S. Petkova +3 more
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