2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses [PDF]
Acta Pharmaceutica, 2020 Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan ...
Serban Georgeta
doaj +3 more sources
Acute toxicity of 3-(2-, 3-fluorophenyl)-6-(aryl-, hetaryl)-[1,2,4]triazole[3,4-b][1,3,4]thiadiazoles [PDF]
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017 Nowadays an attempt to create a number of new biologically active compounds by many scientific groups is being one of the topical issues in the domestic pharmaceutical industry.
O. A. Bihdan, V. V. Parchenko
doaj +3 more sources
Thiadiazoles. III*. Some 5-Substituted Derivatives of 2-Amino-1,3,4-Thiadiazoles and Some Mesoionic 1,3,4-Thiadiazoles [PDF]
Croatica Chemica Acta, 1971 New derivatives of 1,3,4-thiadiazoles with potential phytohormonic (compds. I-V) and antibacterial (compds. VI-IX) activity have been prepared. Mesoionic structure of the compounds VI- IX is indicated by their IR and UV spectra.
Kuftinec, J., Kolbah, D.
openaire +4 more sources
Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles [PDF]
E-Journal of Chemistry, 2011 In the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles (6a-c).
Bahram Letafat +3 more
doaj +2 more sources
Functionalization of 2-Mercapto-5-methyl-1,3,4-thiadiazole: 2-(ω-Haloalkylthio) Thiadiazoles vs. Symmetrical Bis-Thiadiazoles [PDF]
MoleculesA study on the functionalisation of 2-mercapto-5-methyl-1,3,4-thiadiazole has been conducted, yielding two series of products: 2-(ω-haloalkylthio)thiadiazoles and symmetrical bis-thiadiazoles, with variable chain lengths. The experimental conditions were
Zhanina S. Petkova +3 more
doaj +2 more sources
Visible-light-induced intramolecular C–S bond formation for practical synthesis of 2,5-disubstituted 1,3,4-thiadiazoles [PDF]
, 2022 A general and facile visible-light mediated protocol for the synthesis of 2-arylamino-5-aryl-1,3,4- thiadiazoles via one-pot condensation and intramolecular C–S coupling cascade reaction has been developed.
Ruohan Li (6490004) +5 more
core +1 more source
Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review [PDF]
Molecules, 2020 During recent years, small molecules containing five-member heterocyclic moieties have become the subject of considerable growing interest for designing new antitumor agents. One of them is 1,3,4-thiadiazole. This study is an attempt to collect the 1,3,4-thiadiazole and its derivatives, which can be considered as potential anticancer agents, reported ...
Sara Janowska +2 more
openaire +3 more sources
Synthesis Of 2-Benzamidomethyl-5-Substituted Amino-1,3,4-Thiadiazoles-2,5-Disubstituted 1,3,4-Oxadiazole and 4,5-Disubstituted 1,2,4-Triazole-3-Thiol [PDF]
مجلة التربية والعلم, 2012 In this paper the synthesis of some substituted 1,3,4-oxadiazoles , 1,3,4-thiadiazoles and 1,2,4-triazoles starting from amino acid and benzoyl chloride is reported.
K. M. Daoud, A. N. Ali, A. A. Ahmed
doaj +1 more source
Synthesis and Study of Some 4-Chlorophenoxy Methyl Substituted amido1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles and 1,2,4-Triazoles from 4-Chloro phenoxy acetic acid [PDF]
مجلة التربية والعلم, 2013 : In this paper the synthesis of some substituted 1,3,4-oxadiazole, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. 4-Chlorophenol was treated with chloroacetic acid to give 4-chlorophenoxy acetic acid (C1) which was reacted with thionyl chloride ...
Mudhar A. Othman, Khalid M. Daoud
doaj +1 more source
Synthesis of 2- alkyl/phenyl -5-Substituted 1,3,4- Thiadiazoles [PDF]
مجلة التربية والعلم, 2014 In this paper the synthesis of some 2-alkyl phenyl 5-substituted 1,3,4-thiadiazole is reported, Benzonitrile and Acetonitrile were treated with thiosemicarbazide in presence of trifluroacetic acid to give 2-alkyl/ aryl -5- amino- 1,3,4- thiadiazoles (1,2)
Khalid Daoud +2 more
doaj +1 more source