Results 31 to 40 of about 14,599 (204)
, 2022 A general and facile visible-light mediated protocol for the synthesis of 2-arylamino-5-aryl-1,3,4- thiadiazoles via one-pot condensation and intramolecular C–S coupling cascade reaction has been developed.
Ruohan Li (6490004) +5 more
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1,3,4-Thiadiazole: A Promising Pharmacophore
Oriental Journal Of Chemistry, 2023 Active pharmaceutical ingredients (A.P.I.) are made up of various heteroatomic moieties. Numerous heterocycle scaffolds are regarded as crucial structures. More frequently, presence of various heteroatoms viz. nitrogen, sulphur, halogens, and oxygen atoms at different position in 5- or 6-membered rings contributed them as valued source of therapeutic ...
Nidhi Chaudhary +3 more
openaire +1 more source
Synthesis and Biological Evaluation of Some Newer 1H-Benzo[b][1,5]diazepin-2(3H)-one Derivatives as Potential Anticonvulsant Agents [PDF]
Pharmaceutical Sciences, 2022 Background: Regardless of the availability of all novel and earlier treatments, seizure control is notoriously complicated. In the hopes of discovering the latest and ultimate therapy, medicinal chemists will keep on to hunt for new antiepileptic ...
Dinesh D Rishipathak +2 more
doaj +1 more source
Biological activities of imidazo[2,1-b][1,3,4]thiadiazole derivatives: A review
Journal of Saudi Chemical Society, 2016 Imidazo[2,1-b][1,3,4]thiadiazole heterocycle was discovered during the 1950s. Since then, many newer derivatives are being developed and evaluated for their biological profiles. The derivatives of imidazo[2,1-b][1,3,4]thiadiazoles are widely explored for
Bhoomendra A. Bhongade +3 more
doaj +1 more source
Synthesis, Characterization, Molecular Docking Study and Biological Evaluation of Novel 1,3,4-Thiadiazole-Based Heterocycles as Potential Anticancer and Antioxidant Agents. [PDF]
Chem Biol Drug DesA new cyanoacetohydrazide derivative was developed as a key intermediate to synthesize diverse 1,3,4‐thiadiazole‐based heterocyclic compounds. The synthesized compounds were structurally confirmed. Several compounds demonstrated strong cytotoxic activity against HePG‐2 and MCF‐7 cancer cell lines, with compounds 17, 18, and 13 exceeding the activity of
El-Metwaly NM +7 more
europepmc +2 more sources
New 1,3,4-Thiadiazole Derivatives with Anticancer Activity
Molecules, 2022 We designed and synthesized the 1,3,4-thiadiazole derivatives differing in the structure of the substituents in C2 and C5 positions. The cytotoxic activity of the obtained compounds was then determined in biological studies using MCF-7 and MDA-MB-231 breast cancer cells and normal cell line (fibroblasts).
Sara Janowska +8 more
openaire +3 more sources
Molecules, 2011 A new series of thiadiazole-enaminones 4 were synthesized via reactions of 5-acetyl-1,3,4-thiadiazoles 3 with dimethylformamide-dimethylacetal (DMF-DMA).
Thoraya A. Farghaly +2 more
doaj +1 more source
A Novel Approach to the Synthesis of 1,3,4-Thiadiazole-2-amine Derivatives
Molecules, 2021 The main purpose of the study was the development of a new method for synthesis of 1,3,4-thiadiazol-2-amine derivatives in a one-pot manner using the reaction between a thiosemicarbazide and carboxylic acid without toxic additives such as POCl3 or SOCl2.
Tatiana S. Kokovina +3 more
doaj +1 more source
Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017 Introduction. Currently an attempt to combine 1,2,4-triazole heterocycle with various pharmacologically active fragments of other organic molecules is popular among the scientists.
O. A. Bihdan, V. V. Parchenko
doaj +1 more source
Recent Developments In Chemistry Of 1,3,4-Thiadiazoles [PDF]
, 2014 The methods of preparation, structure and biological activities of 1,3,4-thiadiazoles are ...
Mahmoud Fawzy Ismail +3 more
core +1 more source