Results 31 to 40 of about 12,547 (208)

A Novel Approach to the Synthesis of 1,3,4-Thiadiazole-2-amine Derivatives

Molecules, 2021
The main purpose of the study was the development of a new method for synthesis of 1,3,4-thiadiazol-2-amine derivatives in a one-pot manner using the reaction between a thiosemicarbazide and carboxylic acid without toxic additives such as POCl3 or SOCl2.
Tatiana S. Kokovina, Svyatoslav Y. Gadomsky, Alexei A. Terentiev, Nataliya A. Sanina   +3 more
doaj   +1 more source

1,3,4-Thiadiazole: A Promising Pharmacophore

Oriental Journal Of Chemistry, 2023
Active pharmaceutical ingredients (A.P.I.) are made up of various heteroatomic moieties. Numerous heterocycle scaffolds are regarded as crucial structures. More frequently, presence of various heteroatoms viz. nitrogen, sulphur, halogens, and oxygen atoms at different position in 5- or 6-membered rings contributed them as valued source of therapeutic ...
Nidhi Chaudhary, Ranjana Dubey, Tilak Ram, Hament Panwar   +3 more
openaire   +1 more source

1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents [PDF]

Frontiers in Chemistry, 2022
A wide range of biological activities is exhibited by 1,3,4-thiadiazole moiety such as antidiabetic, anticancer, anti-inflammatory, anticonvulsant, antiviral, antihypertensive, and antimicrobial. To date, drugs such as butazolamide, and acetazolamide.
Tulika Anthwal, Sumitra Nain
openaire   +3 more sources

Mechanistic Insight Into the Polymorph‐Dependent Photosalient Effect of a White Light or Two‐Photon Activated Photoreactive Molecular Salt

Angewandte Chemie, EarlyView.
Photocycloaddition in stilbene‐type salt polymorphs exhibit distinct light‐driven responses: OHT‐TI shows a violent photosalient effect under visible and NIR (two‐photon) irradiation, whereas OHT‐TII reacts statically. Packing and computational analysis reveals that shell‐like structures in OHT‐TI frustrate structural relaxation, accumulating explosive
Emanuela Santagata, Francesco Ambrosio, Amedeo Capobianco, Andrea Peluso, Giorgia Rizzi, Stijn Van Cleuvenbergen, Yovan de Coene, Koen Clays, Paolo Pio Mazzeo, Roberto Centore, Fabio Borbone   +10 more
wiley   +2 more sources

Synthesis and Screening of Substituted Thiadiazoles Against Gleophyllum Straitum

E-Journal of Chemistry, 2004
Cyclocondensation of a series of substituted phenoxy methylene carboxylic acids with thiosemoicarbazides afforded 2-Amino-5-Aryloxy Methylene –1,3,4 Thiadiazoles (Ia-Ie).
M. G. H. Zaidi, Seema Zaidi, I. P. Pandey   +2 more
doaj   +1 more source

Syntheses of Diheterocyclic Compounds Based on 2-Thioacetohydrazide-5,7-dimethyl-1,2,4-triazolo[1,5-a]- pyrimidine

Molecules, 2008
The syntheses of some diheterocyclic compounds from 2-thioacetohydrazide- 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (1) are described. Compound 1 can be converted into triazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles.
Guang-Fu Yang, Hai-Yang Tu, Chao-Nan Chen, Qiong Chen, Zu-Ming Liu   +4 more
doaj   +1 more source

A Nano-MgO and Ionic Liquid-Catalyzed 'Green' Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylase (CYP51). [PDF]

PLoS ONE, 2015
In this work, we describe the 'green' synthesis of novel 6-(adamantan-1-yl)-2-substituted-imidazo[2,1-b][1,3,4]thiadiazoles (AITs) by ring formation reactions using 1-(adamantan-1-yl)-2-bromoethanone and 5-alkyl/aryl-2-amino1,3,4-thiadiazoles on a nano ...
Sebastian Anusha, Baburajeev Cp, Chakrabhavi Dhananjaya Mohan, Jessin Mathai, Shobith Rangappa, Surender Mohan, Chandra, Shardul Paricharak, Lewis Mervin, Julian E Fuchs, Mahedra M, Andreas Bender, Basappa, Kanchugarakoppal S Rangappa   +13 more
doaj   +1 more source

Synthesis under Microwave Irradiation of [1,2,4]Triazolo[3,4-b] [1,3,4]thiadiazoles and Other Diazoles Bearing Indole Moieties and Their Antimicrobial Evaluation

Molecules, 2011
Microwave-assisted synthesis of some novel compounds, namely, 3-(2-methyl-1H-indol-3-yl)-6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 5a,b was accomplished via bromination of 2-methyl-3-[4-(arylideneamino)-5-mercapto-4H-[1,2,4]triazol-3-yl]-1H ...
Sobhi M. Gomha, Sayed M. Riyadh
doaj   +1 more source

Synthesis of some substituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles from 2-(2,3-dimethylphenyl amino) benzoic acid [PDF]

مجلة التربية والعلم, 2009
In this paper the synthesis of some substituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles was achieved. 2-(2,3-dimethyl phenyl amino) benzoic acid was esterified to its ethyl ester by its reaction with absolute ethanol in presence of ...
Khalid Daoud, Shereen Mohamed, Nagham Al-Niami   +2 more
doaj   +1 more source

Elemental Sulfur Promoted Cyclization of Aryl Hydrazones and Aryl Isothiocyanates Yielding 2‑Imino-1,3,4-thiadiazoles [PDF]

We report a method for using elemental sulfur to facilitate the cyclization of aryl hydrazones and aryl isothiocyanates, affording biorelated 2-imino-1,3,4-thiadiazoles.
Anh T. Nguyen (7865891), Phuong T. Dinh (8698236), Tan N. Huynh (17935204), Khanh T. N. Ong (17935207), Tung T. Nguyen (7535555)   +4 more
core   +1 more source