Results 71 to 80 of about 14,599 (204)

Synthesis of some Nitro-substituted 1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles and 1,2,4-Triazoles as Antiamebic Agents

, 1989
Post-Graduate Department of Chemistry, University of Jammu, Jammu-180 004 Manuscript received 20 May 1987, revised 15 November 1988, accepted 14 December 1988 Some 2-(\(\beta\)-arylethyl)-5-phenylamino-1,3,4-oxadiazoles, 2-(\(\beta\)-arylethyl)-5 ...
T. C. LANGER, CHARANJIT SINGH ANDOTRA, SHIV KUMAR SHARMA   +2 more
core   +1 more source

An efficient synthesis of styryl 1,3,4-thiadiazoles using Lawesson’s reagent and Propylphosphonic anhydride-precursors for bis heterocycles [PDF]

, 2014
The compounds styryl 1,3,4-thiadiazoles were prepared adopting one and two step methodologies to optimize the yield of the products. The two-step methodology via benzohydrazide followed by treatment with Lawesson’s reagent in the presence of ...
Padmavathi, Venkatapuram, Guda, Mallikarjuna Reddy, Padmaja, Adivireddy, Gundala, Sravya   +3 more
core   +1 more source

Síntese de cristais líquidos isônicos e/ou discóticos contendo os heterociclos 1,2,4- E 1,3,4- oxadiazol [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2013.A presente dissertacao traz o estudo realizado com moleculas derivadas dos heterociclos 1,
Silva, Danilo Henrique da
core  

ESIPT-Related Origin of Dual Fluorescence in the Selected Model 1,3,4-Thiadiazole Derivatives

Molecules, 2020
In our previous work, we discussed the emergence of the dual fluorescence phenomenon in selected compounds from the group of 1,3,4-thiadiazoles. The results obtained in a number of experimental studies, supported by [TD]DFT calculations, clearly ...
Grzegorz Czernel, Iwona Budziak, Anna Oniszczuk, Dariusz Karcz, Katarzyna Pustuła, Andrzej Górecki, Alicja Matwijczuk, Bożena Gładyszewska, Mariusz Gagoś, Andrzej Niewiadomy, Arkadiusz Matwijczuk   +10 more
doaj   +1 more source

Síntese de novos mesógenos derivados do heterocíclo imidazo[2,1-b][1,3,4]tiadiazol [PDF]

, 2009
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.A síntese de seis novas moléculas derivadas do heterociclo imidazo[2,1-b][1,3,4]tiadiazol foram realizadas a partir da construções de ...
Ferraz Neto, José
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Synthesis, Characterization, and Antimicrobial Properties of New 1,3,4‐Thiadiazoles Derived from Azo Dyes

, 2019
Some new 1,3,4‐thiadiazoles derived from azo dyes were synthesized. Two different synthesis methods were used for these compounds: Esters pertaining to the azo dyes were converted into 1,3,4‐thiadiazoles, or benzothiazole ester derivatives were converted
Gür, Mahmut, Mahmut Gür
core   +1 more source

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, Volume 47, Issue 7, Page 855-869, July 2026.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity

Journal of Advanced Research, 2015
Starting from N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides, a series of new functionalized 1,3,4-thiadiazoles were prepared. The structures of the compounds prepared were confirmed by both elemental and spectral analyses as well as by alternate ...
Abdou O. Abdelhamid, Sobhi M. Gomha, Ahmad S. Shawali   +2 more
doaj   +1 more source

Synthesis and antiproliferative studies of 5-aryl-2-(3-thienylamino)-1,3,4- thiadiazoles

, 2014
A series of 5-aryl-2-(3-thienylamino)-1,3,4-thiadiazoles 3a-m were synthesized in good yields in two steps starting from thiophen-3- isothiocyanates.
Gadais, Charlène, Kirsch, Gilbert, Revelant, Germain, Mathieu, Véronique, Hesse, Stéphanie   +4 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source