Results 31 to 40 of about 22,593 (123)

Asymmetric Lewis acid-catalyzed 1,3-dipolar cycloadditions [PDF]

, 2017
Highly tuned, one-point binding chiral iron and ruthenium complexes selectively coordinate and activate α,β-unsaturated aldehydes and ketones toward asymmetric catalytic Diels-Alder cycloaddition reactions.
Brinkmann, Yasmin, Bădoiu, Andrei, Kündig, E. Peter, Viton, Florian   +3 more
core  

Glycerol: a biorenewable solvent for base-free Cu(I)-catalyzed 1,3-dipolar cycloaddition of azides with terminal and 1-iodoalkynes. Highly efficient transformations and catalyst recycling [PDF]

, 2014
Ministerio de Ciencia e Innovacin (MICINN) of Spain [CTQ2010-14796, RYC-2011-08451]; MICINN; European Social ...
García Álvarez, Joaquín, Vidal Vides, Christian   +1 more
core   +1 more source

Bifunctional Molecular Switches in Fused Diarylethene–Rhodamine Systems

ChemPhotoChem, EarlyView.
Spectroscopic and time‐dependent density‐functional theory studies show that these novel rhodamine‐based diarylethene (DAE) compounds display intense UV absorption, undergo reversible two‐step protonation involving triazole and rhodamine units, and respond selectively to acid, base, and metal ions.
Bassima Hoteit, Shunan Zhao, Corentin Poidevin, Arnaud Fihey, Keith Man‐Chung Wong, Julien Boixel   +5 more
wiley   +1 more source

Synthesis of 3,5-Disubstituted Isoxazoles and Isoxazolines in Deep Eutectic Solvents [PDF]

, 2015
The synthesis of different 3,5-disubstituted isoxazoles and related isoxazolines using choline chloride:urea as deep eutectic solvent (DES) in a one-pot three step reaction has been accomplished successfully. The use of highly nucleophilic functionalized
Pérez Galera, Juana María, Ramón, Diego J.   +1 more
core   +3 more sources

Reversible Nanocomposites With Carbon Nanotubes as the Diene in the Diels–Alder Reaction

Polymer Composites, EarlyView.
Scheme of the reversible nanocomposites through DA and rDA reactions with participation of carbon nanotubes. ABSTRACT Carbon nanotubes (CNTs) often require surface functionalization to facilitate uniform distribution and address issues related to aggregation. Due to the sp2 hybridized carbon atoms on their surface, CNTs readily participate in the Diels–
Jie Guo, Nick van der Ploeg, Muhammad Nabil Bin Mubarak Shah, Ranjita K. Bose   +3 more
wiley   +1 more source

One-step synthesis of differently bis-functionalized isoxazoles by cycloaddition of carbamoylnitrile oxide with β-keto esters [PDF]

, 2012
A new protocol for synthesizing different functionalized isoxazoles is provided. Carbamoylnitrile oxide generated from nitroisoxazolone underwent inverse electron-demand 1,3-dipolar cycloaddition with 1,3-dicarbonyl compounds in the presence of magnesium
975, 976, 977, 978, 979, 980, 981, 982, Ariga, Masahiro, Hirao, Shotaro, Ise, Yumiko, Kobiro, Kazuya, Nishiwaki, Nagatoshi, Nishizawa, Maho, Saigo, Kazuhiko, Sawayama, Jun   +15 more
core   +1 more source

Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall, Henry G. Box, Karl A. P. Payne, Stephen A. Marshall, David Leys   +4 more
wiley   +1 more source

Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
The combination of bicyclic monoterpene‐ and pyrrolidine‐alkaloid fragments yields novel pseudo‐natural products. Biological characterization revealed that these iDegs are inhibitors and degraders of indoleamine‐2,3‐dioxygenase. Abstract Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties.
Xiu‐Fen Cheng, Belén Lucas, Philipp Lampe, Stefano Ugel, Suyuan Chen, Anke Unger, Matthias Bischoff, Soheila Rezaei Adariani, Kesava Reddy Naredla, Kamal Kumar, Annika Schmidt, Carsten Strohmann, Petra Janning, Raphael Gasper, María Lucas, Malte Gersch, Sonja Sievers, Vincenzo Bronte, Slava Ziegler, Herbert Waldmann   +19 more
wiley   +2 more sources

Cardenolide‐Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non‐small Cell Lung Cancer Cells

Small Methods, EarlyView.
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Maja Dorfner, Anika Mifka, Rodrigo Maia de Pádua, Izabella Thaís da Silva, Iara Zanella Guterres, Lorenzo Sana, Gregor Fuhrmann, Jennifer Munkert   +7 more
wiley   +1 more source

1,3-Dipolar cycloadditions of azomethine imines [PDF]

, 2015
Azomethine imines are considered 1,3-dipoles of the aza-allyl type which are transient intermediates and should be generated in situ but can also be stable and isolable compounds.
Nájera, Carmen, Sansano, Jose M., Yus, Miguel   +2 more
core   +3 more sources