Results 51 to 60 of about 264,075 (214)

Think Beyond The Core: Computationally Decoding the Hydrophilic Corona of Drug‐Loaded Polymer Micelles

Small, EarlyView.
Drug‐loaded ABA‐type triblock copolymer micelles with a hydrophobic poly(2‐n‐butyl‐2‐oxazine) core (B‐block) and hydrophilic coronas (pEG, pDMAA, pSAR (A‐block)) are investigated by all‐atom molecular dynamics simulations at 20% and 60% curcumin loadings.
Maksym Karachevtsev, Josef Kehrein, Terttu Hukka, Alex Bunker, Mikko Karttunen, Robert Luxenhofer   +5 more
wiley   +1 more source

An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions

Molecules, 2012
A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3 ...
Yucheng Wang, Juxian Wang, Hongtao Liu, Huiyuan Wang, Wei Lin, Lexing Xu, Zhibin Huang, Gang Chen, Qian Zhao, Daqing Shi   +9 more
doaj   +1 more source

Peptide Terminated Polymer Brush Nanomaterials for Label‐Free Separation of Cancer Cells Based on Relative Adhesion

Small, EarlyView.
Horan et al. demonstrate that RGD peptide‐functionalized poly(ethylene glycol) brush films synthesized in polydimethylsiloxane microfluidic channels by surface‐initiated atom transfer radical polymerization enable label‐free separation of melanoma and ovarian cancer cells based on differential integrin expression.
Stephen Horan, Anita Wdowicz, Nathan Feely, Peng Li, Oya Tagit, Wenxin Wang, Gil U Lee   +6 more
wiley   +1 more source

(S)-(-)-Limonene Derivatives Containing (1H-1,2,3-Triazol-4-yl)methyl 4-Bromobenzoate

Molbank, 2011
The synthesis of (S)-(-)-limonene derivatives containing (1H-1,2,3-triazol-4-yl)methyl 4-bromobenzoate were obtained by epoxidation, azidolysis and Huisgen’s 1,3-dipolar cycloaddition.
Guillermo Valdomir, Danilo Davyt
doaj   +1 more source

High‐performance electro‐optic materials featuring enhanced thermal stability through dual‐donor structural crosslinking engineering

Smart Molecules, EarlyView.
A groundbreaking dual‐donor crosslinking strategy was reported to significantly enhance the thermal stability, achieving remarkable EO coefficients (257–301 pm/V), glass transition temperatures (Tg) ranging from 107–187°C, and ultrahigh chromophore densities (3.73–4.26 × 10²⁰ molecules/cm³) with exceptional long‐term stability after 500 h at 85°C ...
Yu Zhang, Ziyun Zheng, Zhihan Huang, Zhifan Liu, Youling Chen, Fuyang Huo, Fenggang Liu, Xiubin Xu   +7 more
wiley   +1 more source

Photo‐Triggered, Fast, and Fluorogenic Thiophene‐Based Cycloalkynes for the Bioorthogonal Fluorescent Labeling of 1,3‐Dipole‐Tagged Molecules in No‐Wash Conditions

Angewandte Chemie, Volume 138, Issue 35, 24 August 2026.
Thiophene is king! The fusion of thiophene rings to cycloalkynes super‐charged their copper‐free click chemistry applications, by (1) enhancing the alkyne reactivity (fastest cyclooctyne to date) and (2) rendering the alkyne fluorogenic (with fluorescence enhancement up to 150‐fold upon reaction), making these bioorthogonal reagents ideal for tracking ...
Jurgen Schulz, Zoeisha S. Chinoy, Tarek Khalaf, Yukang Li, Pengchen Ma, Dennis Svatunek, Kendall N. Houk, Frédéric Friscourt   +7 more
wiley   +2 more sources

Microwave-Assisted Synthesis of Fluorescent Pyrido[2,3-b]indolizines from Alkylpyridinium Salts and Enaminones

Molecules, 2020
Pyridinium ylides are well recognized as dipoles for cycloaddition reactions. In its turn, the microwave-assisted interaction of N-(cyanomethyl)-2-alkylpyridinium salts with enaminones unexpectedly proceeds as a domino sequence of cycloisomerization and ...
Ekaterina A. Sokolova, Alexey A. Festa, Karthikeyan Subramani, Victor B. Rybakov, Alexey V. Varlamov, Leonid G. Voskressensky, Erik V. Van der Eycken   +6 more
doaj   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Decarboxylation-Driven Double Annulations: Innovative Multi-Component Reaction Pathways

Molecules
A concerted five-component reaction strategy has been developed, featuring double [3+2] cycloadditions utilizing aspartic acid. This approach provides valuable insights into mechanistic pathways, allowing for the distinction between concerted and ...
Desheng Zhan, Gang Yang, Tieli Zhou, Sashirekha Nallapati, Xiaofeng Zhang   +4 more
doaj   +1 more source

Structural and mutational analysis of Methanosarcina mazei prenylated FMN synthase reveals the basis of its unique prenyl donor substrate specificity

The FEBS Journal, EarlyView.
Some prenylated flavin mononucleotide (prFMN) synthases exceptionally prefer dimethylallyl phosphate (DMAP) over dimethylallyl diphosphate (DMAPP), which is a common prenyl donor substrate for many prenyltransferases. Structural and mutagenic analyses of Methanosarcina mazei prFMN synthase, which prefers DMAP but can also accept DMAPP, elucidated its ...
Sou Fukuhara, Hideaki Unno, Soma Ishimine, Ryuhei Nagata, Tomokazu Ito, Hisashi Hemmi   +5 more
wiley   +1 more source