Results 61 to 70 of about 16,669 (224)

One Step Regioselective Synthesis of 5-Aminoisoxazoles from Nitrile Oxides and α-Cyanoenamines

Molecules, 2004
The 1,3-dipolar cycloaddition of nitrile oxides to 1-cyanoenamines gives 5-aminoisoxazoles regioselectively. Moderate to good yields could be obtained depending on the method used to generate the nitrile oxides. The intermediate isoxazolines could not be
Aïcha Derdour, Michel Vaultier, Amar Saad   +2 more
doaj   +1 more source

A Modular Synthesis of Isoindole/Indolizine Hybrids via the 1,3‐Dipolar Cycloaddition of Pyridine‐Based Mesoionics with Benzyne

European Journal of Organic Chemistry, EarlyView.
An approach to prepare pyrido[2,1‐a]isoindoles via the cycloaddition of pyridine‐based 1,3‐dipoles and benzyne is described, offering modular access to a range of substituted products by systematic tuning of the dipole. A modular strategy for the synthesis of fused indolizine/isoindole hybrids, pyrido[2,1‐α]isoindoles, via cycloaddition of pyridine ...
Samira Taghizadeh Nodehi, Mohammad Ghanbari, Bruce A. Arndtsen   +2 more
wiley   +1 more source

Quantification of the electrophilic reactivities of nitroalkenes [PDF]

, 2012
While a large variety of nucleophiles (N and sN) have been characterized according to eq 1.3, the number of E parameters for electrophiles, and specifically for different classes of Michael acceptors remains relatively small.
Zenz, Ivo
core  

Synthesis of 2‐Aza‐Bicyclo[4.3.0]nonane Derivatives Related to the Camporidines via Intramolecular [3+2]‐Cycloaddition

European Journal of Organic Chemistry, EarlyView.
The intramolecular nitrile oxide olefin [3 + 2]‐cycloaddition offers a reliable entry toward 2‐aza‐bicyclo[4.3.0]‐nonanes, a substructure found in several bioactive piperidine alkaloids. The required oxime precursors were prepared in non‐racemic form by Ir‐catalyzed asymmetric allylation and ring‐closing metathesis.
Alicia Köcher, Tobias Wilczek, Nora Katharina Korber, Jörg-Martin Neudörfl, Bernd Goldfuss, Hans-Günther Schmalz   +5 more
wiley   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions

Molecules, 2012
A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3 ...
Yucheng Wang, Juxian Wang, Hongtao Liu, Huiyuan Wang, Wei Lin, Lexing Xu, Zhibin Huang, Gang Chen, Qian Zhao, Daqing Shi   +9 more
doaj   +1 more source

High‐performance electro‐optic materials featuring enhanced thermal stability through dual‐donor structural crosslinking engineering

Smart Molecules, EarlyView.
A groundbreaking dual‐donor crosslinking strategy was reported to significantly enhance the thermal stability, achieving remarkable EO coefficients (257–301 pm/V), glass transition temperatures (Tg) ranging from 107–187°C, and ultrahigh chromophore densities (3.73–4.26 × 10²⁰ molecules/cm³) with exceptional long‐term stability after 500 h at 85°C ...
Yu Zhang, Ziyun Zheng, Zhihan Huang, Zhifan Liu, Youling Chen, Fuyang Huo, Fenggang Liu, Xiubin Xu   +7 more
wiley   +1 more source

Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes – synthesis and COX-2 inhibition activity

, 2018
By Ru(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes 3,4-diaryl-substituted isoxazoles are formed in one step, showing high inhibition potency for COX-2.
Roscales García, Silvia, Pietzsch, Jens, Kniess, Torsten, Holger Weiss, Daniel, Torsten Kniess, Köckerling, Martin, Martin Köckerling, Bechmann, Nicole, Daniel Holger Weiss, Nicole Bechmann, Silvia Roscales, Jens Pietzsch   +11 more
core   +1 more source

(S)-(-)-Limonene Derivatives Containing (1H-1,2,3-Triazol-4-yl)methyl 4-Bromobenzoate

Molbank, 2011
The synthesis of (S)-(-)-limonene derivatives containing (1H-1,2,3-triazol-4-yl)methyl 4-bromobenzoate were obtained by epoxidation, azidolysis and Huisgen’s 1,3-dipolar cycloaddition.
Guillermo Valdomir, Danilo Davyt
doaj   +1 more source

N‐Glycosyl Triazoline Glycomimetics via Huisgen Cycloaddition With an Electron‐Deficient Alkene and BF3‐Catalysed Triazoline Fragmentation to Aziridines

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Glycomimetics with triazoline and aziridine groups were synthesised via diastereoselective Huisgen cycloaddition from glycosyl azides. Density functional theory was applied to define the mechanism for BF3 promoted aziridine formation. Triazoline and aziridine derivatives were synthesised by diastereo‐ and regioselective Huisgen cycloaddition of 2,3,4,6‐
Aaron McCormack, Ashis Dhara, Lamis Alaa Eldin Refat, Mikael Bols, Paul V. Murphy   +4 more
wiley   +1 more source