Results 71 to 80 of about 264,075 (214)

New Quinazolin-4(3H)-One Derivatives Incorporating Isoxazole Moiety as Antioxidant Agents: Synthesis, Structural Characterization, and Theoretical DFT Mechanistic Study

Pharmaceuticals
Background: This research centers on the development and spectroscopic characterization of new quinazolin-4(3H)-one-isoxazole derivatives (5a–e). The aim was to investigate the regioselectivity of the 1,3-dipolar cycloaddition involving arylnitriloxides ...
Yassine Rhazi, Riham Sghyar, Noemi Deak, Bouchra Es-Sounni, Bouchra Rossafi, Albert Soran, Mustapha Laghmari, Azize Arzine, Asmae Nakkabi, Khalil Hammani, Samir Chtita, Mohammed M. Alanazi, Gabriela Nemes, Mohamed El. Yazidi   +13 more
doaj   +1 more source

One-pot Microwave-Assisted Synthesis of 1H-Phenanthro[9,10- d][1,2,3]triazole

Molbank, 2008
In this study, a fast and good yield one-pot microwave-assisted synthesis (45 seconds) of 1H-phenanthro[9,10-d][1,2,3]triazole by a 1,3-dipolar cycloaddition reaction of sodium azide and 9-bromophenanthrene in the presence of potassium tert-butoxide in ...
Mehrak Faraji, Avat Arman Taherpour
doaj   +1 more source

1,3‐Dipolar Cycloaddition of Nitroalkanes as a Tool of DOS/LOS‐Like Strategy for the Synthesis of Isoxazoles and Isoxazolines

ChemistryEurope, Volume 4, Issue 9, September 2026.
A broadly applicable synthetic platform based on a DOS/LOS‐like strategy is implemented for the case of sp3‐enriched isoxazole/isoxazoline building blocks. The method is based on a [3+2] cycloaddition of nitroalkanes and various alkenes or alkynes. The utility of the proposed approach is illustrated by the discovery of JAK2‐selective inhibitors.
Bohdan A. Chalyk, Kostiantyn O. Halos, Anastasiia Grynyova, Bohdan S. Sosunovych, Bohdan V. Vashchenko, Oleksandr Zginnyk, Anna Beshtynarska, Nataliia Shliakhtova, Petro Borysko, Angelina V. Biitseva, Konstantin S. Gavrilenko, Dmytro M. Volochnyuk, Oleksandr O. Grygorenko   +12 more
wiley   +1 more source

Synthesis and Biological Evaluation of Well‐Defined M6P(n)‐Modified Glycopeptides for Targeted Protein Degradation

Chemistry – A European Journal, Volume 32, Issue 33, 1 September 2026.
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Patrycja Lenartowicz, Jan‐Willem H. Langenbach, Nataliia Voloshyna, David Aidukas, Arwin J. Brouwer, John A. W. Kruijtzer, Geert‐Jan Boons   +6 more
wiley   +1 more source

Peptide Macrocyclization via Cu-catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides [PDF]

Cyclic peptides are highly valued synthetic targets in organic and medicinal chemistry. The development of new synthetic methodologies for peptide macrocyclization, different from classical lactamization, is essential for the progress of the field ...
Francisco Javier, Adrio, Juan Carlos, Carretero, Inés, Alonso, Enrique, Gallent, Nuria, Rodriguez   +4 more
core   +1 more source

A Diastereoselective Synthesis of Dispiro[oxindole-cyclohexanone]pyrrolidines by 1,3-Dipolar Cycloaddition

Molecules, 2017
For the first time, arylmethylidene cyclohexanones that are non-symmetrical due to the presence of peripheral substituents were studied in 1,3-dipolar cycloaddition reactions.
Alexander Anis’kov, Irina Klochkova, Roman Tumskiy, Alevtina Yegorova   +3 more
doaj   +1 more source

Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes

Beilstein Journal of Organic Chemistry, 2011
An efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles was achieved. The synthesis involves the [3 + 2] dipolar cycloaddition of 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes. The process proceeds smoothly in moderate to excellent yields. 1,3-Diaryl-4-
Yiwen Yang, Chunxiang Kuang, Hui Jin, Qing Yang, Zhongkui Zhang   +4 more
doaj   +1 more source

1,3-Dipolar Cycloaddition Reactions of trans-2-Methylene-1,3-dithiolane 1,3-Dioxide with Nitrones

, 2016
1,3-Dipolar Cycloaddition Reactions of trans-2-Methylene-1,3-dithiolane 1,3-Dioxide with ...
Peter L. Spargo (3042906), Varinder K. Aggarwal (1363332), Richard S. Grainger (1335045), Harry Adams (1327698)   +3 more
core   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes – synthesis and COX-2 inhibition activity

, 2018
By Ru(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes 3,4-diaryl-substituted isoxazoles are formed in one step, showing high inhibition potency for COX-2.
Roscales García, Silvia, Pietzsch, Jens, Kniess, Torsten, Holger Weiss, Daniel, Torsten Kniess, Köckerling, Martin, Martin Köckerling, Bechmann, Nicole, Daniel Holger Weiss, Nicole Bechmann, Silvia Roscales, Jens Pietzsch   +11 more
core   +1 more source