Results 1 to 10 of about 5,065 (202)

Antileishmanial and Antitoxoplasmal Activities of 1,4-Dihydropyridines [PDF]

ACS Omega
Abstract: We have synthesized 24 1,4-dihydropyridine compounds (1,4-DHPs) with different substituents at the aromatic ring by microwave-assisted one-pot Hantzsch multicomponent reac-tion and evaluated their in vitro activities against Toxoplasma gondii and Leishmania major.
Thaís A. S. Oliveira, Yan R. Robles, Ibrahim S. Al Nasr, Waleed S. Koko, Tariq A. Khan, Ismail Daoud, Seyfeddine Rahali, Noureddine Amdouni, Ridha B. Said, Antônio E. M. Crotti   +9 more
doaj   +3 more sources

Data for the synthesis and characterisation of 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines as important intermediates for synthesis of amphiphilic 1,4-dihydropyridines [PDF]

Data in Brief, 2020
This data file describes the synthetic protocol for preparation of the original 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines. In total, 6 unpublished compounds were obtained and characterised.
Martins Rucins, Klavs Pajuste, Arkadij Sobolev, Mara Plotniece, Nadiia Pikun, Karlis Pajuste, Aiva Plotniece   +6 more
doaj   +2 more sources

Ammonium metavanadate (NH4VO3): a highly efficient and eco-friendly catalyst for one-pot synthesis of pyridines and 1,4-dihydropyridines [PDF]

Scientific Reports, 2022
In this study, we reported the ammonium metavanadate (NH4VO3) as an efficient, cost-effective, and mild catalyst for the synthesis of substituted pyridines via a one-pot pseudo four-component reaction.
Jamal Rahimi, Maryam Niksefat, Marzieh Heidari, Mehdi Naderi, Hadis Abbasi, Mohammad Tajik Ijdani, Ali Maleki   +6 more
doaj   +2 more sources

Acyl-1,4-Dihydropyridines: Universal Acylation Reagents for Organic Synthesis [PDF]

Molecules
Acyl-1,4-dihydropyridines have recently emerged as universal acylation reagents. These easy-to-make and bench-stable NADH biomimetics play the dual role of single-electron reductants and sources of acyl radicals.
Karthikeyan Manoharan, Bartosz Bieszczad
doaj   +2 more sources

Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates [PDF]

Molecules, 2015
The ethoxycarbonylmethyl esters of 1,4-dihydropyridines were directly converted into carbamoylmethyl esters in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) in good to excellent yields under mild conditions.
Brigita Vigante, Martins Rucins, Aiva Plotniece, Karlis Pajuste, Iveta Luntena, Brigita Cekavicus, Egils Bisenieks, Rufus Smits, Gunars Duburs, Arkadij Sobolev   +9 more
doaj   +3 more sources

Synthesis of Indenones via Persulfate Promoted Radical Alkylation/Cyclization of Biaryl Ynones with 1,4-Dihydropyridines [PDF]

Molecules
The oxidative radical cascade cyclization of alkynes has emerged as a versatile strategy for the efficient construction of diverse structural units and complex molecules in organic chemistry.
Wanwan Wang, Lei Yu
doaj   +2 more sources

A Microwave-Assisted Bismuth Nitrate-Catalyzed Unique Route Toward 1,4-Dihydropyridines [PDF]

Molecules, 2012
The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives.
Bimal K. Banik, Stephanie Maldonado, Debasish Bandyopadhyay   +2 more
doaj   +4 more sources

b-Annulated 1,4-dihydropyridines as Notch inhibitors. [PDF]

Bioorg Med Chem Lett, 2018
The Notch signaling pathway is involved in cell proliferation and differentiation, and has been recognized as an active pathway in regenerating tissue and cancerous cells. Notch signaling inhibition is considered a viable approach to the treatment of a variety of conditions including colorectal cancer, pancreatic cancer, breast cancer and metastatic ...
Gómez-Galeno JE, Hurtado C, Cheng J, Yardimci C, Mercola M, Cashman JR.   +5 more
europepmc   +4 more sources

Dually Acting Nonclassical 1,4-Dihydropyridines Promote the Anti-Tuberculosis (Tb) Activities of Clofazimine [PDF]

Molecules, 2019
The number of effective antituberculotic drugs is strongly limited to four first-line drugs in standard therapy. In case of resistances second-line antibiotics are used with a poor efficacy and tolerability.
Fabian Lentz, Norbert Reiling, Gabriella Spengler, Annamária Kincses, Andrea Csonka, Joseph Molnár, Andreas Hilgeroth   +6 more
doaj   +2 more sources

Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel K_Ca3.1. [PDF]

Proc Natl Acad Sci U S A
The 1,4-dihydropyridines, drugs with well-established bioavailability and toxicity profiles, have proven efficacy in treating human hypertension, peripheral vascular disorders, and coronary artery disease. Every 1,4-dihydropyridine in clinical use blocks
Ong ST, Nam YW, Nasburg JA, Ramanishka A, Ng XR, Zhuang Z, Goay SSM, Nguyen HM, Singh L, Singh V, Rivera A, Eyster ME, Xu Y, Alper SL, Wulff H, Zhang M, Chandy KG.   +16 more
europepmc   +3 more sources