Results 61 to 70 of about 5,065 (202)

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

Repurposing drugs to fast-track therapeutic agents for the treatment of cryptococcosis [PDF]

, 2018
Many infectious diseases disproportionately affect people in the developing world. Cryptococcal meningitis is one of the most common mycoses in HIV-AIDS patients, with the highest burden of disease in sub-Saharan Africa.
Afeltra, Bicanic, Butts, Byrnes, Catterall, Ceballos, Chatterji, Chong, Chrysant, Clinical and Laboratory Standards Institute (CLSI), Clinical and Laboratory Standards Institute (CLSI), Cruz, Cruz, Cumino, Dehdashti, Del Poeta, Dzoyem, Edlind, Espinel-Ingroff, Feldmeier, Gaggi, Hagen, Hong, Hong, Horton, Jarvis, Joffe, Kneale, Lai, Lassègue, Liu, Liu, Loyse, Meiring, Nixon, Oprea, Park, Peiter, Perfect, Prole, Rabjohns, Rajasingham, Rhein, Samantaray, Smith, Spagnuolo, Spitzer, Teng, Téllez-Girón, Zhai, Zhai   +50 more
core   +3 more sources

Bis‐Furans: A Sustainable Source of Diverse Molecular Architectures

European Journal of Organic Chemistry, EarlyView.
A concise synthetic route to diverse acyclic and heterocyclic compounds has been developed by combining hetero‐Diels–Alder reactions, DBU‐promoted ring openings, and Lewis base‐catalyzed annulations. Nitrosoalkenes reacted with furan derivatives to form 4a,7a‐dihydro‐4H‐furo[2,3‐e][1,2]oxazines, which underwent DBU‐promoted rearrangements to 6H‐1,2 ...
Ana L. Cardoso, José A. Paixão, Teresa M. V. D. Pinho e Melo   +2 more
wiley   +1 more source

Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes [PDF]

The prototype 1,4-dihydropyridine (1,4-DHP) nifedipine, indicated for the management of hypertension and angina pectoris, has drawbacks of rapid onset of vasodilating action and a short half-life.
Baarnhielm, Beresford, Borchard, Kobayashi, Mahmoudian, Mahmoudian, Mohri, Moldeus, Ramsch, Roden, Scherling, Scherling, Scherling, Stopher, Teramura, Van Zwieten   +15 more
core   +1 more source

Structural investigations of the regio- and enantioselectivity of lipases [PDF]

, 1998
Although lipases are widely applied for the stereospecific resolution of racemic mixtures of esters, the atomic details of the factors that are responsible for their stereospecificity are largely obscure. We determined the X-ray structures of Pseudomonas
Bando, Bencsura, Brady, Brzozowski, Cygler, Derewenda, Derewenda, Desnuelle, Egloff, Gilbert, Godfrey, Grochulski, Grochulski, Grochulski, Hermoso, Hirose, Jaeger, Kazlauskas, Kim, Kordel, Kovach, Lang, Lawson, Longhi, Mannesse, Martinez, Noble, Ollis, Pascher, Rogalska, Schrag, Schrag, Sussman, Taipa, Theil, Uppenberg, Uppenberg, van Tilbeurgh, Winkler   +38 more
core   +2 more sources

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, EarlyView.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source

Oxidation of Hantzsch 1,4- Dihydropyridines to Pyridines with Thallium Triacetate [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2003
Hantzsch 1, 4-dihydropyridines (1,4-DHPs) can be oxidized to the corresponding pyridine derivatives by thallium triacetate in high yields.
Mohammad Mahmoodi Hashemi, Mohammad Sadegh Zakeri, Saeed Arianfar   +2 more
doaj  

Benign synthesis of therapeutic agents: domino synthesis of unsymmetrical 1,4-diaryl-1,4-dihydropyridines in the ball-mill

Green Chemistry Letters and Reviews, 2022
The solvent-free preparation of unsymmetrical N-aryl-5,6-unsubstituted-1,4-dihydropyridines (DHPs) by ball-milling was investigated. Three different mechanochemical domino reactions (one-pot/one step or stepwise) were studied, the process parameters ...
Cristina Blazquez-Barbadillo, Juan Francisco González, Andrea Porcheddu, David Virieux, José Carlos Menéndez, Evelina Colacino   +5 more
doaj   +1 more source

Who Lives in a Tin Can Under the (Ultrasonic) Sea: Sponges Made From Perfluoropyridine‐Derived Thiol‐Ene Polymerizations

Journal of Polymer Science, Volume 64, Issue 4, Page 833-847, 15 February 2026.
Tandem mechanochemical‐sonochemical for the strategic synthesis for 2,4,6‐trisubstituted derivatives of perfluoropyridine as bio‐based prepolymer materials. ABSTRACT Substitution of perfluoropyridine (PFP) in the 4‐position through an SNAr reaction is facile through mechanochemical methods, with yields in excess of 99% and short reaction times on a ...
Jason Pulfer, Miriam Aldom, Maxime Colpaert, Andrea Kelley, Tim Storr, Chadron M. Friesen   +5 more
wiley   +1 more source

Hydrogen Transfer from Hantzsch 1,4-Dihydropyridines to Carbon-Carbon Double Bonds under Microwave Irradiation

Molecules, 2002
1,4-Dihydropyridines (DHPs) have been used in the reduction of carbon-carbon double bonds under microwave irradiation without solvent. The efficiency of the reactions is dramatically dependent on the steric effects in the DHPs and on the electronic ...
Jean Jacques Vanden Eynde, Didier Barbry, Guy Cordonnier, Séverine Torchy   +3 more
doaj   +1 more source