Results 181 to 190 of about 2,904,339 (217)

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

Journal of Psychiatric Research, 2002
The brain is the most cholesterol-rich organ in the human body. Accumulation of excess cholesterol in hippocampal neurons promotes the cleavage of the amyloid precursor protein (APP) into amyloidogenic components with the consequence of the acceleration of neuronal degeneration.
Papassotiropoulos, A., Lütjohann, D., Bagli, M., Locatelli, S., Jessen, F., Buschfort, R., Ptok, U., Björkhem, I., von Bergmann, K., Heun, R.   +9 more
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24S-hydroxycholesterol in plasma: A marker of cholesterol turnover in neurodegenerative diseases

Biochimie, 2013
Brain cholesterol is mainly involved in the cell membrane structure, in signal transduction, neurotransmitter release, synaptogenesis and membrane trafficking. Impairment of brain cholesterol metabolism was described in neurodegenerative diseases, such as Multiple Sclerosis, Alzheimer and Huntington Diseases.
Leoni, V, Caccia, C
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Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer’s disease

Expert Review of Neurotherapeutics, 2006
Cholesterol and the cholesterol oxide 24S-hydroxycholesterol (24S-HC) are highly enriched in the human CNS. Clinical, genetic, neurochemical and epidemiological evidence continue to support dysfunctional cholesterol metabolism as an important contributing factor driving the development and/or progression of Alzheimer's disease (AD) neuropathology ...
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24S‐hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis

Journal of Neuroscience Research, 2007
AbstractLevels of the brain‐specific cholesterol metabolite 24S‐hydroxycholesterol are proposed as possible biomarkers for multiple sclerosis (MS). It is not yet clear for which aspect of the MS disease manifestations 24S‐hydroxycholesterol is a reflection.
Teunissen, C E, Floris, S, Sonke, M, Dijkstra, C D, De Vries, H E, Lütjohann, D   +5 more
openaire   +3 more sources

Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): Argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity

Revue Neurologique, 2015
Cholesterol oxide derivatives (oxysterols) are viewed as potential biomarkers of neurodegenerative diseases. 24S-hydroxycholesterol, an oxysterol produced only in brain neurons, is often found for unknown reasons in increased levels in the plasma in patients with neurodegenerative diseases. On human neuronal SK-N-BE cells treated with hexacosanoic acid
A, Zarrouk, M, Hammami, T, Moreau, G, Lizard   +3 more
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The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells

Brain Research, 1999
Neurodegenerative disorders are characterized by a massive loss of nerve cells. The neuronal cell death is accompanied by an increased cholesterol release and conversion of cholesterol into the polar metabolite, 24-hydroxycholesterol (24-OH-Chol), appears to be an important mechanism in the central nervous system for eliminating cholesterol from the ...
H, Kölsch, D, Lütjohann, A, Tulke, I, Björkhem, M L, Rao   +4 more
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The role of 24S-hydroxycholesterol in Alzheimer's disease.

The journal of nutrition, health & aging, 2003
Studies on Alzheimer's disease (AD) revealed that cholesterol metabolism might be involved in the pathogenesis of this neurodegenerative disorder. The apolipoprotein E4 genotype is a known risk factor in AD. Elevated serum cholesterol concentrations are detected in patients with AD and two recent epidemiological studies have indicated that treatment ...
H, Kölsch, D, Lütjohann, K, von Bergmann, R, Heun   +3 more
openaire   +1 more source

7β-Hydroxycholesterol induces Ca2+ oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells

Atherosclerosis, 2000
In the present study, we characterize the early cytotoxic effects of 7β-hydroxycholesterol, a major cytotoxin in oxidized LDL, in human aortic smooth muscle cells. Within a few minutes after addition, 7β-hydroxycholesterol induced Ca 2+ oscillations with
Mikko P S Ares, Johan Thyberg, Lisa Juntti-Berggren   +2 more
exaly   +2 more sources

Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S‐hydroxycholesterol

Acta Paediatrica, 2001
Oxysterols, particularly those hydroxylated in the steroid side‐chain, are formed from cholesterol by specific cytochrome P450 enzymes and may facilitate elimination of cholesterol from extrahepatic sources. In humans, the greatest portion of circulating 24S‐hydroxycholesterol (24S‐OH‐Chol) is derived from the brain and the absolute concentration ...
D, Lütjohann, I, Björkhem, S, Locatelli, C, Dame, J, Schmolling, K, von Bergmann, H, Fahnenstich   +6 more
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Lecithin cholesterol acyltransferase esterifies 24s-hydroxycholesterol in cerebrospinal fluid

2010
Alteration of cholesterol (Ch) homeostasis is involved in the pathogenesis of neurodegeneration. Astrocyte-derived lecithin cholesterol acyltransferase (LCAT) was recently shown capable of esterifying Ch on ApoE-lipoproteins.In order to prevent Ch excess in neurons, it can be converted in 24Shydroxycholesterol (24-OH Ch).
CIGLIANO, LUISA, Spagnuolo M. S., Maresca B., Pugliese C. R., La Marca V., ABRESCIA, PAOLO   +5 more
openaire   +3 more sources