Results 181 to 190 of about 13,032 (223)

24S-Hydroxycholesterol: a Marker of Brain Cholesterol Metabolism

Pharmacopsychiatry, 2003
The enzymatic conversion of CNS cholesterol to 24S-hydroxycholesterol, which readily crosses the blood-brain barrier, is the major pathway for brain cholesterol elimination and brain cholesterol homeostasis maintenance. The enzyme mediating this conversion has been characterized at the molecular level (CYP46) and is mainly located in neurons.
D, Lütjohann, K, von Bergmann
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Plasma 24S-hydroxycholesterol

NeuroReport, 2000
The conversion of brain cholesterol into 24S-hydroxycholesterol and its subsequent release into the periphery is probably an important step for the maintenance of brain cholesterol homeostasis. Recent findings suggest that plasma 24S-hydroxycholesterol may be elevated in Alzheimer's disease (AD) and vascular dementia at least at some stage of the ...
Papassotiropoulos, A., Lütjohann, D., Bagli, M., Locatelli, S., Jessen, F., Rao, M. L., Maier, W., Björkhem, I., von Bergmann, K., Heun, R.   +9 more
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Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases

Neuroscience Letters, 2000
The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance.
Brétillon, Lionel, Siden, A., Wahlund, L.O., Lütjohann, D., Minthon, L., Crisby, M., Hillert, J., Groth, C.G., Diczfalusy, U., Bjorkhem, Ingemar   +9 more
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24‐Hydroxycholesterol levels in human brain¹

Journal of Neurochemistry, 1972
24‐Hydroxycholesterol (cerebrosterol, cholest‐5‐ene‐3β;, 24ξ‐diol) occurs at low levels in human (Di Frisco, De Ruggieri and Ercoli, 1953; Ercoli and De Ruggieri, 1953a, 19536; Schubert, Rose and Burger, 1961; Van Lier and Smith, 1969, 1970), equine (Ercoli, Di Frisco and De Ruggieri, 1953a; Ercoli and De Ruggieri, 1953a, 1953b; Fieser, Huang and ...
Leland L. SMITH, D. R. Ray, J. A. Moody, J. D. Wells, J. E. Van Lier   +4 more
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Lecithin cholesterol acyltransferase esterifies 24s-hydroxycholesterol in cerebrospinal fluid

2010
Alteration of cholesterol (Ch) homeostasis is involved in the pathogenesis of neurodegeneration. Astrocyte-derived lecithin cholesterol acyltransferase (LCAT) was recently shown capable of esterifying Ch on ApoE-lipoproteins.In order to prevent Ch excess in neurons, it can be converted in 24Shydroxycholesterol (24-OH Ch).
CIGLIANO, LUISA, Spagnuolo M. S., Maresca B., Pugliese C. R., La Marca V., ABRESCIA, PAOLO   +5 more
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24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells

NeuroReport, 2005
24S-hydroxycholesterol, the primary oxidation product of cholesterol in the brain, plays a key role in cholesterol elimination and homeostasis. While the concentration of this neurotoxic oxysterol decreases with age, 24S-hydroxycholesterol is elevated in Alzheimer's disease.
Piotr, Alexandrov, Jian-Guo, Cui, Yuhai, Zhao, Walter J, Lukiw   +3 more
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Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer’s disease

Expert Review of Neurotherapeutics, 2006
Cholesterol and the cholesterol oxide 24S-hydroxycholesterol (24S-HC) are highly enriched in the human CNS. Clinical, genetic, neurochemical and epidemiological evidence continue to support dysfunctional cholesterol metabolism as an important contributing factor driving the development and/or progression of Alzheimer's disease (AD) neuropathology ...
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Degradation of 24S-hydroxycholesterol in men is not regulated by CYP7A1

Int. Journal of Clinical Pharmacology and Therapeutics, 2007
The conversion of cholesterol into bile acids occurs via a long cascade of enzymatically regulated oxidative processes. Our aim was to examine if an up-regulation of hepatic cholesterol 7alpha-hydroxylase (CYP7A1) in humans by cholestyramine, a bile acid-binding resin, has an effect on the degradation of brain-specific 24S-hydroxycholesterol.Six ...
C, Knabe, T, Sudhop, K, von Bergmann, D, Lütjohann   +3 more
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24S-hydroxycholesterol affects redox homeostasis in human glial U-87 MG cells

Molecular and Cellular Endocrinology, 2019
The cholesterol metabolite 24(S)-hydroxycholesterol (24S-OHC) allows cholesterol excretion from the brain and was suggested to be critically involved in physiological as well as neurodegenerative processes. It induces on human neuronal cell cultures a dose dependent toxicity associated with increased reactive oxygen species production.
Cigliano L, Spagnuolo MS, Napolitano G, Iannotta L, FASCIOLO, GIANLUCA, Barone D, Venditti P   +6 more
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