Results 191 to 200 of about 13,032 (223)

24S‐hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis

Journal of Neuroscience Research, 2007
AbstractLevels of the brain‐specific cholesterol metabolite 24S‐hydroxycholesterol are proposed as possible biomarkers for multiple sclerosis (MS). It is not yet clear for which aspect of the MS disease manifestations 24S‐hydroxycholesterol is a reflection.
Teunissen, C E, Floris, S, Sonke, M, Dijkstra, C D, De Vries, H E, Lütjohann, D   +5 more
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24S-Hydroxycholesterol in Neuropsychiatric Diseases: Schizophrenia, Autism Spectrum Disorder, and Bipolar Disorder

2023
Neuropsychiatric diseases (NPDs) are severe, debilitating psychiatric conditions that affect the nervous system. These are among the most challenging disorders in medicine. Some examples include Alzheimer's, anxiety disorders, autism spectrum disorder, bipolar disorder, and schizophrenia.
Meriam, Messedi, Fatma, Makni-Ayadi
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24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

Journal of Psychiatric Research, 2002
The brain is the most cholesterol-rich organ in the human body. Accumulation of excess cholesterol in hippocampal neurons promotes the cleavage of the amyloid precursor protein (APP) into amyloidogenic components with the consequence of the acceleration of neuronal degeneration.
Papassotiropoulos, A., Lütjohann, D., Bagli, M., Locatelli, S., Jessen, F., Buschfort, R., Ptok, U., Björkhem, I., von Bergmann, K., Heun, R.   +9 more
openaire   +2 more sources

The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells

Brain Research, 1999
Neurodegenerative disorders are characterized by a massive loss of nerve cells. The neuronal cell death is accompanied by an increased cholesterol release and conversion of cholesterol into the polar metabolite, 24-hydroxycholesterol (24-OH-Chol), appears to be an important mechanism in the central nervous system for eliminating cholesterol from the ...
H, Kölsch, D, Lütjohann, A, Tulke, I, Björkhem, M L, Rao   +4 more
openaire   +2 more sources

24S-hydroxycholesterol in plasma: A marker of cholesterol turnover in neurodegenerative diseases

Biochimie, 2013
Brain cholesterol is mainly involved in the cell membrane structure, in signal transduction, neurotransmitter release, synaptogenesis and membrane trafficking. Impairment of brain cholesterol metabolism was described in neurodegenerative diseases, such as Multiple Sclerosis, Alzheimer and Huntington Diseases.
Leoni, V, Caccia, C
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The role of 24S-hydroxycholesterol in Alzheimer's disease.

The journal of nutrition, health & aging, 2003
Studies on Alzheimer's disease (AD) revealed that cholesterol metabolism might be involved in the pathogenesis of this neurodegenerative disorder. The apolipoprotein E4 genotype is a known risk factor in AD. Elevated serum cholesterol concentrations are detected in patients with AD and two recent epidemiological studies have indicated that treatment ...
H, Kölsch, D, Lütjohann, K, von Bergmann, R, Heun   +3 more
openaire   +1 more source

24S-Hydroxycholesterol and Cerebellar Degeneration: Insights from SCA2

The Cerebellum, 2022
Locci S., Nidiaci V., De Stefano N., Leoni V., Mignarri A.   +4 more
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Cholesterol metabolism and glaucoma: Modulation of Muller cell membrane organization by 24S-hydroxycholesterol

Chemistry and Physics of Lipids, 2017
Glaucoma is a progressive and irreversible blinding neuropathy that is characterized by the loss of retinal ganglion cells (RGCs). Muller Glial Cell (MGC) activation is induced in retinal gliosis. MGCs are the most numerous glial cells in the retina and one of their roles is to sustain cholesterol homeostasis. 24S-hydroxycholesterol (24S-OHC) is one of
Gambert, Ségolène, Gabrielle, Pierre Henry, Masson, Elodie A.Y., Léger-Charnay, Elise, Ferrerro, A, Vannier, Arthur, Gendrault, Clément, Lachot, Méline, Creuzot-Garcher, Catherine, Bron, Alain, Grégoire, Stéphane, Leclere, Laurent, Martine, L, Lucchi, Géraldine, Truntzer, Caroline, Pecqueur, Delphine, Brétillon, Lionel   +16 more
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Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): Argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity

Revue Neurologique, 2015
Cholesterol oxide derivatives (oxysterols) are viewed as potential biomarkers of neurodegenerative diseases. 24S-hydroxycholesterol, an oxysterol produced only in brain neurons, is often found for unknown reasons in increased levels in the plasma in patients with neurodegenerative diseases. On human neuronal SK-N-BE cells treated with hexacosanoic acid
A, Zarrouk, M, Hammami, T, Moreau, G, Lizard   +3 more
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Hepatic uptake and metabolism of ingested 24-hydroxycholesterol and 24(S),25-epoxycholesterol

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1993
Although two hepatic sterol metabolites, 24(S)-hydroxycholesterol and 24(S),25-epoxycholesterol, are thought to be important regulators of cholesterol biosynthesis, nothing is known of their degradation and disposal in liver, nor of the mechanisms that regulate their levels.
Saucier, S E, Kandutsch, A A, Clark, D S, Spencer, T A   +3 more
openaire   +2 more sources