Results 191 to 200 of about 2,904,339 (217)
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2023
Cholesterol regulates fluidity and structure of cellular membranes. The brain is involved in signal transduction, synaptogenesis, and membrane trafficking. An impairment of its metabolism was observed in different neurodegenerative diseases, such as Multiple Sclerosis, Alzheimer, and Huntington diseases.
Tripodi D. +3 more
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Cholesterol regulates fluidity and structure of cellular membranes. The brain is involved in signal transduction, synaptogenesis, and membrane trafficking. An impairment of its metabolism was observed in different neurodegenerative diseases, such as Multiple Sclerosis, Alzheimer, and Huntington diseases.
Tripodi D. +3 more
openaire +2 more sources
2023
Neuropsychiatric diseases (NPDs) are severe, debilitating psychiatric conditions that affect the nervous system. These are among the most challenging disorders in medicine. Some examples include Alzheimer's, anxiety disorders, autism spectrum disorder, bipolar disorder, and schizophrenia.
Meriam, Messedi, Fatma, Makni-Ayadi
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Neuropsychiatric diseases (NPDs) are severe, debilitating psychiatric conditions that affect the nervous system. These are among the most challenging disorders in medicine. Some examples include Alzheimer's, anxiety disorders, autism spectrum disorder, bipolar disorder, and schizophrenia.
Meriam, Messedi, Fatma, Makni-Ayadi
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24‐Hydroxycholesterol levels in human brain1
Journal of Neurochemistry, 197224‐Hydroxycholesterol (cerebrosterol, cholest‐5‐ene‐3β;, 24ξ‐diol) occurs at low levels in human (Di Frisco, De Ruggieri and Ercoli, 1953; Ercoli and De Ruggieri, 1953a, 19536; Schubert, Rose and Burger, 1961; Van Lier and Smith, 1969, 1970), equine (Ercoli, Di Frisco and De Ruggieri, 1953a; Ercoli and De Ruggieri, 1953a, 1953b; Fieser, Huang and ...
Leland L. SMITH +4 more
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24S-hydroxycholesterol affects redox homeostasis in human glial U-87 MG cells
Molecular and Cellular Endocrinology, 2019The cholesterol metabolite 24(S)-hydroxycholesterol (24S-OHC) allows cholesterol excretion from the brain and was suggested to be critically involved in physiological as well as neurodegenerative processes. It induces on human neuronal cell cultures a dose dependent toxicity associated with increased reactive oxygen species production.
Cigliano L +6 more
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24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells
NeuroReport, 200524S-hydroxycholesterol, the primary oxidation product of cholesterol in the brain, plays a key role in cholesterol elimination and homeostasis. While the concentration of this neurotoxic oxysterol decreases with age, 24S-hydroxycholesterol is elevated in Alzheimer's disease.
Piotr, Alexandrov +3 more
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24S-Hydroxycholesterol and Cerebellar Degeneration: Insights from SCA2
The Cerebellum, 2022Locci S. +4 more
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Chemistry and Physics of Lipids, 2017
Glaucoma is a progressive and irreversible blinding neuropathy that is characterized by the loss of retinal ganglion cells (RGCs). Muller Glial Cell (MGC) activation is induced in retinal gliosis. MGCs are the most numerous glial cells in the retina and one of their roles is to sustain cholesterol homeostasis. 24S-hydroxycholesterol (24S-OHC) is one of
Gambert, Ségolène +16 more
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Glaucoma is a progressive and irreversible blinding neuropathy that is characterized by the loss of retinal ganglion cells (RGCs). Muller Glial Cell (MGC) activation is induced in retinal gliosis. MGCs are the most numerous glial cells in the retina and one of their roles is to sustain cholesterol homeostasis. 24S-hydroxycholesterol (24S-OHC) is one of
Gambert, Ségolène +16 more
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Absolute configurations of 24-hydroxycholesterol and related compounds
Tetrahedron Letters, 1975Naoyuki Koizumi +4 more
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