Results 111 to 120 of about 4,298,356 (197)

Serum 25-hydroxycholesterol levels are increased in patients with coronavirus disease 2019. [PDF]

J Clin Lipidol, 2023
Asano T, Wakabayashi T, Kondo Y, Okada K, Yamamuro D, Koga Y, Oka K, Sakurai M, Sawayama N, Takahashi M, Okazaki H, Ebihara K, Minami K, Morisawa Y, Hatakeyama S, Matsumura M, Ishibashi S.   +16 more
europepmc   +1 more source

Metabolism of 4 beta -hydroxycholesterol in humans

, 2002
One of the major oxysterols in the human circulation is 4 beta-hydroxycholesterol formed from cholesterol by the drug-metabolizing enzyme cytochrome P450 3A4.
Björkhem, Ingemar, Norlin, Maria,, Diczfalusy, Ulf, Andersson, Ulla, Eggertsen, Gösta, Rystedt, Eva, Ellis, Eva, Bodin, Karl, Pikuleva, Irina   +8 more
core   +1 more source

Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling. [PDF]

Circulation, 2023
Canfrán-Duque A, Rotllan N, Zhang X, Andrés-Blasco I, Thompson BM, Sun J, Price NL, Fernández-Fuertes M, Fowler JW, Gómez-Coronado D, Sessa WC, Giannarelli C, Schneider RJ, Tellides G, McDonald JG, Fernández-Hernando C, Suárez Y.   +16 more
europepmc   +1 more source

Hepatic uptake and metabolism of ingested 24-hydroxycholesterol and 24(S),25-epoxycholesterol.

, 1993
Although two hepatic sterol metabolites, 24(S)-hydroxycholesterol and 24(S),25-epoxycholesterol, are thought to be important regulators of cholesterol biosynthesis, nothing is known of their degradation and disposal in liver, nor of the mechanisms ...
Kandutsch, A A, Spencer, T A, Clark, D S, Saucier, S E   +3 more
core   +1 more source

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology
Oxysterols are bioactive cholesterol oxidation products that link lipid metabolism, inflammation, immune regulation, and tumor progression. This review summarizes the generation, sensing, and cancer‐related functions of major oxysterols, with a ...
Haili Shang, Yongsheng Li
doaj   +1 more source

25-Hydroxycholesterol-induced Osteoblast Oxiapoptophagy Is Involved in the Pathophysiological Process of Osteoporosis. [PDF]

In Vivo, 2023
Seo YS, Kang KR, Lim H, Seo JY, Kim DK, Kim JS.   +5 more
europepmc   +1 more source

Studies on 4b-hydroxycholesterol, a marker of CYP3A activity, and its association with 25-hydroxyvitamin D [Elektronisk resurs]

, 2015
Cholesterol is a vital compound that can undergo cytochrome P450 (CYP) mediated conversion into steroid hormones, bile acids and oxysterols. CYP enzymes are present in all human tissues and mediate the metabolism of several endogenous and exogenous ...
Nylén, H
core  

Suppression of endocytosis in polyclonally activated Con A-stimulated T lymphocytes by 25-hydroxycholesterol.

, 1983
Endocytosis in polyclonally activated, Con A-stimulated spleen cell cultures was analyzed. It was found that as lymphocytes differentiate to acquire cytotoxic capability their endocytic activity also increases, reaching a plateau at 48 hr.
Sodergren, A, Heiniger, H J, Marshall, J D   +2 more
core   +1 more source

Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types. [PDF]

iScience, 2022
Limbad C, Doi R, McGirr J, Ciotlos S, Perez K, Clayton ZS, Daya R, Seals DR, Campisi J, Melov S.   +9 more
europepmc   +1 more source

25-hydroxycholesterol in inflammation

Current Opinion in Endocrine and Metabolic Research
Romeo Carre, Solenne Vigne, Caroline Pot
openaire   +1 more source