Results 111 to 120 of about 3,018,278 (209)

Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts.

, 1985
Biosynthetically tritiated sterols from Chinese hamster lung (Dede) cells were fractionated by high performance liquid chromatography, and fractions were assayed for their ability to repress 3-hydroxy-3-methylglutaryl-CoA reductase in L cell cultures.
Kandutsch, A A, Gayen, A K, Spencer, T A, Saucier, S E, Phirwa, S, Taylor, F R   +5 more
core  

Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. [PDF]

, 2014
Type I interferon (IFN) protects against viruses, yet it also has a poorly understood suppressive influence on inflammation. Here, we report that activated mouse macrophages lacking the IFN-stimulated gene cholesterol 25-hydroxylase (Ch25h) and that are ...
McDonald, Jeffrey, Reboldi, Andrea, Russell, David, Cyster, Jason, Liang, Guosheng, Dang, Eric   +5 more
core   +1 more source

Editorial: 25-Hydroxycholesterol: a new life in immunology

Journal of Leukocyte Biology, 2010
Abstract A discussion on paper by Park and Scott revealing the signaling pathways leading to the synthesis of a potent immunoregulatory oxysterol by macrophage and dendritic cells.
Jeffrey G McDonald, David W Russell
openaire   +2 more sources

Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection

, 2017
From various screens, we found that Kaposi’s sarcoma-associated herpesvirus (KSHV) viral microRNAs (miRNAs) target several enzymes in the mevalonate/cholesterol pathway.
Ontara Sarker, Anna K. P. Serquiña, Diane M. Kambach, Joseph M. Ziegelbauer   +3 more
core   +1 more source

Metabolism of 4 beta -hydroxycholesterol in humans

, 2002
One of the major oxysterols in the human circulation is 4 beta-hydroxycholesterol formed from cholesterol by the drug-metabolizing enzyme cytochrome P450 3A4.
Björkhem, Ingemar, Norlin, Maria,, Diczfalusy, Ulf, Andersson, Ulla, Eggertsen, Gösta, Rystedt, Eva, Ellis, Eva, Bodin, Karl, Pikuleva, Irina   +8 more
core   +1 more source

25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

Nature Communications, 2016
The mechanism underlying neuroinflammation in X-linked adrenoleukodystrophy (ALD) is poorly understood. Here authors identify aberrant production of 25-hydroxycholesterol (25-HC) in ALD patient-derived cells, and show that 25-HC mediates ...
Jiho Jang, Sangjun Park, Hye Jin Hur, Hyun-Ju Cho, Inhwa Hwang, Yun Pyo Kang, Isak Im, Hyunji Lee, Eunju Lee, Wonsuk Yang, Hoon-Chul Kang, Sung Won Kwon, Je-Wook Yu, Dong-Wook Kim   +13 more
doaj   +1 more source

Studies on 4b-hydroxycholesterol, a marker of CYP3A activity, and its association with 25-hydroxyvitamin D

, 2015
Cholesterol is a vital compound that can undergo cytochrome P450 (CYP) mediated conversion into steroid hormones, bile acids and oxysterols. CYP enzymes are present in all human tissues and mediate the metabolism of several endogenous and exogenous ...
Hanna Nylén (18685588)
core  

Data_supplemental table 1_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2

, 2019
Data of supplemental table 1 from Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2 Dataset (doi:10.1016/j.jsbmb.2019.03.011) contains the original ...
Seuwen, Klaus, Kanagaratnam, Sharavan, Kratschmar, Denise V., Birk, Julia, Sailer, Andreas W., Odermatt, Alex, Beck, Katharina R., Yamaguchi, Hideaki   +7 more
core   +1 more source

Inhibition of protein synthesis blocks the response to 25-hydroxycholesterol by inhibiting degradation of hydroxymethylglutaryl-CoA reductase.

, 1982
The activity of the rate-limiting enzyme of the cholesterol biosynthetic pathway, 3-hydroxy-3-methylglutaryl coenzyme A reductase in Chinese hamster ovary (CHO) cells decreased more rapidly in cells treated with 25-hydroxycholesterol alone (t 1/2 = 1 ...
Kandutsch, A A, Chen, H W, Richards, B A
core  

Sterol synthesis in variant Chinese hamster lung cells selected for resistance to 25-hydroxycholesterol. Cross-resistance to 7-ketocholesterol, 20alpha-hydroxycholesterol, and serum.

, 1979
Two lines of Chinese hamster lung (Dede) cells which are resistant to the killing effect of 25-hydroxycholesterol, and which grow to confluence in its presence, have been isolated.
Kandutsch, A A, Chen, H W, Cavenee, W K
core