Results 121 to 130 of about 12,744 (156)

The role of 25-hydroxycholesterol in the pathophysiology of brain vessel dysfunction associated with infection and cholesterol dysregulation.

Dis Model Mech
Tapia VS, Withers SE, Zhou R, Bennington A, Hoyle C, Hedley F, El Khouja A, Luka N, Massimo M, Crilly S, Long KR, Lawrence CB, Kasher PR.   +12 more
europepmc   +1 more source

Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients. [PDF]

Cell Death Discov
Wang T, Gong M, Lu Y, Zhao C, Ling L, Chen J, Ju R.   +6 more
europepmc   +1 more source

Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival. [PDF]

Oxid Med Cell Longev, 2020
Cao Q, Liu Z, Xiong Y, Zhong Z, Ye Q.
europepmc   +1 more source

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner. [PDF]

J Neuroinflammation, 2020
Wong MY, Lewis M, Doherty JJ, Shi Y, Cashikar AG, Amelianchik A, Tymchuk S, Sullivan PM, Qian M, Covey DF, Petsko GA, Holtzman DM, Paul SM, Luo W.   +13 more
europepmc   +1 more source

25-hydroxycholesterol promotes brain endothelial dysfunction by remodelling cholesterol metabolism

Tapia VS, Withers SE, Zhou R, Bennington A, Hedley F, El Khouja A, Luka N, Massimo M, Crilly S, Long KR, Lawrence CB, Kasher PR.   +11 more
europepmc   +1 more source

Deletion of CH25H and LIPA Genes in Human Abolishes Biosynthesis of 25-Hydroxycholesterol but not of 7α,25-Dihydroxysterols and Enhances Non-enzymatic Cholesterol Oxidation: Metabolic Changes are Partially Reversed by Hematopoietic Stem Cell Transplant^‡

Yutuc E, Ghosh A, Abdel-Khalik J, Goenka A, Asgari MA, Lopez-Castejon G, Beaman GM, Wynn RF, Newman WG, Jones SA, Griffiths WJ, Wang Y.   +11 more
europepmc   +1 more source

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25-hydroxycholesterol: Gatekeeper of intestinal IgA

Immunity, 2021
High levels of cholesterol and diets high in fat are associated with immune dysfunction and inflammatory disease. In this issue of Immunity, Trindade et al. (2021) report how the cholesterol metabolite 25-hydroxycholesterol restrains IgA plasma cell differentiation from germinal-center B cells in the Peyer's patches through regulation of the sterol ...
Christopher J M, Piper, Claudia, Mauri
openaire   +2 more sources

Synthesis of ent-25-hydroxycholesterol

Steroids, 2006
25-Hydroxycholesterol (25-HC) appears to play a role in several important biological processes, including regulating cellular cholesterol levels and promoting apoptosis. However, in most cases the mechanisms by which 25-HC elicits its biological effects are not known.
Emily J, Westover, Douglas F, Covey
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Complementary recessive 25‐hydroxycholesterol‐resistant somatic cell mutants – assay of 25‐hydroxycholesterol binding activity

Journal of Cellular Physiology, 1982
AbstractComplementation analysis of recessive 25‐hydroxycholesterol‐resistant mutants of the CHO‐KI cell shows the existence of at least two complementation groups, one of which is missing a binding activity for 25‐hydroxycholesterol. Both complementation groups are shown to be refractory to inhibition of cellular HMG‐CoA reductase activity and in the ...
M, Sinensky, J, Logel, R, Torget
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