Results 171 to 180 of about 5,521 (201)
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Mutagenic Effect of 3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid
Nature, 1969MANY metabolites of tryptophane found in the urine of patients with leukaemia1,2 and bladder tumours3–12 induce tumours in experimental animals13–16.
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Ultraviolet filter compounds in human lenses: 3-hydroxykynurenine glucoside formation
Vision Research, 1994Experiments have been conducted on various aspects of the biosynthetic pathway leading to the formation of 3-hydroxykynurenine glucoside (3OHKG), the major tryptophan-derived human lens UV filter compound. Measurable levels of the reactive metabolite, 3-hydroxykynurenine (3OHKyn) were found in normal human lenses, including lens nuclei. 3OHKyn was able
A M, Wood, R J, Truscott
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Oxidation of 3-hydroxykynurenine catalyzed by methemoglobin with hydrogen peroxide
Free Radical Biology and Medicine, 1992Methemoglobin (metHb) with H2O2 catalyzed the oxidation of 3-hydroxykynurenine (3-HKY) in the reaction mixture of metHb, 3-HKY, and H2O2. The spectrophotometric experiments suggest the following mechanism for the 3-HKY oxidation by metHb with H2O2. MetHb first reacts with H2O2 to form the ferryl complex of Hb. This species then oxidizes 3-HKY, while it
T, Ishii +3 more
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Distribution of [3H]-3-hydroxykynurenine in mice.
Cancer research, 1976The distribution of 3-hydroxykynurenine, a tryptophan metabolite that is suspected of being carcinogenic, was studied in mice. After s.c. administration of [3H]-3-hydroxykynurenine into male BALB/c X DBA/2 F1 mice, the distribution of 3H was investigated by whole-body autoradiography and radioactivity measurement.
Watanabe, M, Sugimori, Y
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Elucidation of a Novel Polypeptide Cross-Link Involving 3-Hydroxykynurenine
Biochemistry, 19993-Hydroxykynurenine, a metabolite of tryptophan, is a powerful antioxidant and neurotoxin. The neurotoxicity results from the oxidation of 3-hydroxykynurenine, and hydroxyl radicals, formed via H(2)O(2), may also be implicated [Okuda, S., Nishiyama, N., Saito, H. , and Katsuki, H. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 12553-12558].
J A, Aquilina +2 more
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ChemInform Abstract: Oxidation of 3‐Hydroxykynurenine. An EPR Investigation.
ChemInform, 1991AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. BOLOGNESE +3 more
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The Protective Role of HSP90 against 3-Hydroxykynurenine-Induced Neuronal Apoptosis
Biochemical and Biophysical Research Communications, 20013-hydroxykynurenine (3HK), an endogenous metabolite of tryptophan in the kynurenine pathway, is a potential neurotoxin in several neurodegenerative disorders. Stabilizing protein structure, heat shock proteins (HSPs) have diverse roles as molecular chaperones to mediate stress tolerance.
M W, Lee +9 more
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Chemotaxonomy and Chemomimicry: The Case of 3-Hydroxykynurenine
Systematic Zoology, 1967The distributional data for the metabolic amino acid 3-hydroxy-L-kynurenine as a wing pigment in nymphalid butterflies would suggest taxonomic groupings essentially in contradiction with those resulting from more broad-scale morphological, breeding and behavioral studies; this indicates that the storage of this pigment is a taxonomically relatively ...
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European Archives of Psychiatry and Clinical Neuroscience, 2012
Increased degradation of tryptophan (TRP) through the kynurenine (KYN) pathway (KP) is known to be involved in the molecular mechanisms resulting in the neuropathogenesis of Alzheimer's disease (AD). Activation of the KP leads to the production of neurotoxic metabolites 3-hydroxykynurenine (3-HK) and quinolinic acid (QUIN) by immune cells and ...
Schwarz, Markus J +4 more
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Increased degradation of tryptophan (TRP) through the kynurenine (KYN) pathway (KP) is known to be involved in the molecular mechanisms resulting in the neuropathogenesis of Alzheimer's disease (AD). Activation of the KP leads to the production of neurotoxic metabolites 3-hydroxykynurenine (3-HK) and quinolinic acid (QUIN) by immune cells and ...
Schwarz, Markus J +4 more
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3‐hydroxykynurenine and other Parkinson's disease biomarkers discovered by metabolomic analysis
Movement Disorders, 2013ABSTRACTParkinson's disease (PD) biomarkers are needed to enhance therapeutics research and to understand PD pathogenesis. Methods that simultaneously measure hundreds of small molecular‐weight compounds—metabolomic analysis–“fingerprint” disease‐specific alterations in individual compounds or metabolic pathways.
Peter A, Lewitt +5 more
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