Results 101 to 110 of about 259,851 (238)
Insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes.
, 2014 Differentiated 3T3-L1 adipocytes were treated with or without TNF-α (3 ng/ml) for 72 h in the presence or absence of Igf2 (400 ng/ml). *P≤0.05.
Yuji Arai (174599) +6 more
core +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims The triglyceride–glucose (TyG) index is associated with insulin resistance and cardiovascular disease (CVD), but the underlying mechanisms remain unclear. As ceramides are implicated in both insulin resistance and CVD, we investigated the association between the TyG index and plasma ceramides in individuals with Type 2 diabetes (T2D ...
Laure Carpentier +7 more
wiley +1 more source
Journal of Diabetes Research, 2016 We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks.
Chihiro Moriya, Hiroaki Satoh
doaj +1 more source
TNFα impairs fatty acid oxidation in 3T3-L1 adipocytes.
, 2006 TNFα impairs fatty acid oxidation in 3T3-L1 ...
T Connor (13300326) +5 more
core
Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling
The FEBS Journal, EarlyView.Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch +7 more
wiley +1 more source
Schematic diagram for the effect of PPC on lipolysis and apoptosis in 3T3-L1 adipocytes.
, 2019 Schematic diagram for the effect of PPC on lipolysis and apoptosis in 3T3-L1 adipocytes.
Hyeong-Dong Kim (6564710) +11 more
core +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
Functional expression of TRPM7 as a Ca2+ influx pathway in adipocytes
Physiological Reports, 2019 In adipocytes, intracellular Ca2+ and Mg2+ modulates physiological functions, such as insulin action and the secretion of adipokines. TRPM7 is a Ca2+/Mg2+‐permeable non‐selective cation channel.
Hana Inoue +3 more
doaj +1 more source
Understanding extracellular vesicles in antiaging
Periodontology 2000, EarlyView.Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad +3 more
wiley +1 more source
Characteristics of 3T3-L1 cells with Brd2 knockdown.
, 2013 3T3-L1 cells were transfected with Brd2 shRNA (SiBrd2) or scramble shRNA (SiC) plasmids respectively. (A) Adipogenic differentiation of 3T3-L1 adipocytes from pre-adipocytes and Oil Red O staining on day 4 of treatment reveals lipids in cells that have ...
Jingyu Wang (292122) +9 more
core +1 more source