Results 91 to 100 of about 259,851 (238)

Iodothyronine Interactions with the System L1 Amino Acid Exchanger in 3T3-L1 Adipocytes

, 2010
Thyroid hormones enter isolated white adipocytes largely by a System L1-type amino acid transporter en route to exerting genomic actions. Differentiated 3T3-L1 mouse adipocytes in culture express mRNA for LAT1 (the catalytic subunit of high-affinity ...
Lisa A. Roy, Mitchell, Fiona, Roy, Lisa A, Peter M. Taylor, Fiona E. Mitchell, Taylor, Peter M   +5 more
core   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

An ameloblastin C-terminus variant is present in human adipose tissue

Heliyon, 2018
Objective: Transcriptional regulatory elements in the ameloblastin (AMBN) promoter indicate that adipogenesis may influence its expression. The objective here was to investigate if AMBN is expressed in adipose tissue, and have a role during ...
Øystein Stakkestad, Catherine Heyward, Ståle Petter Lyngstadaas, Tirill Medin, Jiri Vondrasek, Aina-Mari Lian, Gita Pezeshki, Janne Elin Reseland   +7 more
doaj   +1 more source

MST and SAV1 stimulate the differentiation of 3T3-L1 adipocytes.

, 2013
(A) Overexpression of MST2 and SAV1 stimulated differentiation of 3T3-L1 adipocytes. 3T3-L1 pre-adipocytes were transfected with PPARγ, SAV1 and/or MST2 expression plasmids and then stimulated with the minimal differentiation cocktail.
Gun Woo Won (334130), Yong Hee Lee (334135), Dae Soon Kim (334129), Byung-Chul Oh (334132), YoungJoo Lee (334133), Eung-Gook Kim (334134), Byoung Hee Park (334128), Hyun Jeong Jeon (334131)   +7 more
core   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Downregulation of REDD1 expression inhibits lipogenesis in 3T3-L1 adipocytes.

, 2012
3T3-L1 adipocytes were transfected with REDD1 siRNA. 48 h after transfection, 3T3-L1 adipocytes were incubated with [3H] sodium acetate (0.4 mmol/l, 0.5 µCi/ml) in absence or in presence of insulin 1 nM for 1 hour at 37°C.
Claire Regazzetti (111898), Pascal Peraldi (70204), Sophie Giorgetti-Peraldi (111912), Yannick Le Marchand-Brustel (111906), Jean-François Tanti (111910), Karine Dumas (111902)   +5 more
core   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

INFLUENCE OF 5,7-DIMETHOXY COUMARIN ON ADIPOGENESIS IN HIGH GLUCOSE INDUCED INSULIN RESISTANT 3T3-L1 ADIPOCYTES [PDF]

Insulin resistance in adipocytes disrupts whole-body metabolic homeostasis contributing to various complications. This study investigates the adipogenic potential of 5,7-dimethoxy Coumarin (5,7-DMC) in high glucose-induced insulin resistance in 3T3-L1 ...
J. JOHN ROBERT, C. SANKARANARAYANAN, R. SARUMATHI   +2 more
core   +1 more source

Inhibition of the NR4A1‐mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity.
Wanning Qiao, Cun Ku, G. V. Naveen Kumar, Jonathan D. Brown, Manni Wu, Chenhang Li, Jiyu Xie, Huicui Meng, Litao Sun, Tao Zhou, Dong Liang, Yiwei Li, Matthew L. Steinhauser, Yang Zhang   +13 more
wiley   +1 more source

Cytoprotective role of the fatty acid binding protein 4 against oxidative and endoplasmic reticulum stress in 3T3-L1 adipocytes

FEBS Open Bio, 2014
The fatty acid binding protein 4 (FABP4), one of the most abundant proteins in adipocytes, has been reported to have a proinflammatory function in macrophages. However, the physiological role of FABP4, which is constitutively expressed in adipocytes, has
Kazuaki Kajimoto, Yoshitaka Minami, Hideyoshi Harashima   +2 more
doaj   +1 more source