Results 21 to 30 of about 259,851 (238)

The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis

Journal of Lipid Research, 2005
This study assessed the effects of selective inhibitors of 3′,5′-cyclic nucleotide phosphodiesterases (PDEs) on adipocyte lipolysis. IC224, a selective inhibitor of type 1 phosphodiesterase (PDE1), suppressed lipolysis in murine 3T3-L1 adipocytes (69.6 ±
Peter B. Snyder, James M. Esselstyn, Kate Loughney, Sharon L. Wolda, Vincent A. Florio   +4 more
doaj   +1 more source

Regucalcin enhances adipocyte differentiation and attenuates inflammation in 3T3‐L1 cells

FEBS Open Bio, 2020
Dysregulation of adipocyte differentiation and dysfunction play key roles in the pathogenesis of obesity and associated disorders such as diabetes and metabolic syndrome, and as such, a better understanding of the molecular mechanism of adipogenesis may ...
Tomiyasu Murata, Masayoshi Yamaguchi, Susumu Kohno, Chiaki Takahashi, Watanabe Risa, Kanna Hatori, Kiyomi Hikita, Norio Kaneda   +7 more
doaj   +1 more source

Topiramate effects lipolysis in 3T3-L1 adipocytes

Biomedical Reports, 2015
Studies have shown that topiramate (TPM)-induced weight loss can be dependent on the central nervous system (CNS). However, the direct action of TPM on adipose tissue has not been tested previously. Thus, the present study aimed to examine whether TPM modulates lipolysis in 3T3-L1. The 3T3-L1 cells were incubated in 50 µM TPM for 30 min.
Campagnaro Martins, Gabriela Poltronieri, Souza, Camila Oliveira, Marques, Scherolin De Oliveira, Luciano, Thais Fernandes, Da Silva Pieri, Bruno Luiz, Rosa, Jose Cesar, Ramos Da Silva, Adelino Sanchez, Pauli, Jose Rodrigo, Cintra, Dennys Esper, Ropelle, Eduardo Rochete, Rodrigues, Bruno, De Lira, Fabio Santos, De Souza, Claudio Teodoro   +12 more
openaire   +4 more sources

Sclerostin Enhances Adipocyte Differentiation in 3T3‐L1 Cells [PDF]

Journal of Cellular Biochemistry, 2016
ABSTRACTSclerostin, a secreted protein encoded by the Sost gene, is produced by osteocytes and is inhibited by osteoblast differentiation and bone formation. Recently, a functional association between bone and fat tissue has been suggested, and a correlation between circulating sclerostin levels and lipid metabolism has been reported in humans. However,
Ukita, Mayumi, Yamaguchi, Taihiko, Ohata, Noboru, Tamura, Masato   +3 more
openaire   +4 more sources

Novel Function of α-Cubebenoate Derived from Schisandra chinensis as Lipogenesis Inhibitor, Lipolysis Stimulator and Inflammasome Suppressor

Molecules, 2020
The efficacy of α-cubebenoate isolated from Schisandra chinensis has been previously studied in three disease areas, namely inflammation, sepsis, and allergy, and its role in other diseases is still being explored.
Su Ji Bae, Ji Eun Kim, Yun Ju Choi, Su Jin Lee, Jeong Eun Gong, Young-Whan Choi, Dae Youn Hwang   +6 more
doaj   +1 more source

Oroxylum indicum (L.) Kurz extract inhibits adipogenesis and lipase activity in vitro

BMC Complementary and Alternative Medicine, 2018
Background Oroxylum indicum (L.) Kurz (O. indicum) is found in Thailand. It has been used for the treatment of obesity. This study aimed to investigate the effects of an O.
Tanaporn Hengpratom, Gordon M. Lowe, Kanjana Thumanu, Siriporn Suknasang, Kanokwan Tiamyom, Griangsak Eumkeb   +5 more
doaj   +1 more source

Anti-Obesity Effect of α-Cubebenol Isolated from Schisandra chinensis in 3T3-L1 Adipocytes

Biomolecules, 2021
The efficacy of α-cubebenol isolated from Schisandra chinensis has been studied in several diseases, including cecal ligation, puncture challenge-induced sepsis, and degranulation of neutrophils.
Su Jin Lee, Ji Eun Kim, Yun Ju Choi, Jeong Eun Gong, You Jeong Jin, Da Woon Lee, Young Whan Choi, Dae Youn Hwang   +7 more
doaj   +1 more source

Sinapic acid prevents adipogenesis by regulating transcription factors and exerts an anti-ROS effect by modifying the intracellular anti-oxidant system in 3T3-L1 adipocytes [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): In this study, we tested the hypothesis that sinapic acid (SA), a naturally occurring hydroxycinnamic acid found in vegetables, cereal grains, and oilseed crops with various biological activities suppresses adipogenesis in 3T3-L1 adipocytes
Cordelia John, Sumathy Arockiasamy
doaj   +1 more source

Characterizing 3T3-L1 MBX Adipocyte Cell Differentiation Maintained with Fatty Acids as an In Vitro Model to Study the Effects of Obesity

Life, 2023
The increasing prevalence of obesity has prompted intensive research into understanding its role in pathogenesis and designing appropriate treatments. To determine the signals generated from the interaction of fat cells with a target organ, a reliable ...
Noshin Mubtasim, Lauren Gollahon
doaj   +1 more source

Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]

, 1994
The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Wetekam, Eva-Marlen, Wied, Susanne, Pünter, Jürgen, Unkelbach, Angelika, Crecelius, Anna, Müller, Günter   +5 more
core   +1 more source