The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis
Journal of Lipid Research, 2005 This study assessed the effects of selective inhibitors of 3′,5′-cyclic nucleotide phosphodiesterases (PDEs) on adipocyte lipolysis. IC224, a selective inhibitor of type 1 phosphodiesterase (PDE1), suppressed lipolysis in murine 3T3-L1 adipocytes (69.6 ±
Peter B. Snyder +4 more
doaj +1 more source
Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization [PDF]
, 2016 Scope: Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown adipose tissue dissipating energy to produce heat in mammals.
Bao, Yong P. +10 more
core +1 more source
PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]
, 2020 Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun +11 more
core +1 more source
Topiramate effects lipolysis in 3T3-L1 adipocytes
Biomedical Reports, 2015 Studies have shown that topiramate (TPM)-induced weight loss can be dependent on the central nervous system (CNS). However, the direct action of TPM on adipose tissue has not been tested previously. Thus, the present study aimed to examine whether TPM modulates lipolysis in 3T3-L1. The 3T3-L1 cells were incubated in 50 µM TPM for 30 min.
Campagnaro Martins, Gabriela Poltronieri +12 more
openaire +4 more sources
Regucalcin enhances adipocyte differentiation and attenuates inflammation in 3T3‐L1 cells
FEBS Open Bio, 2020 Dysregulation of adipocyte differentiation and dysfunction play key roles in the pathogenesis of obesity and associated disorders such as diabetes and metabolic syndrome, and as such, a better understanding of the molecular mechanism of adipogenesis may ...
Tomiyasu Murata +7 more
doaj +1 more source
Molecules, 2020 The efficacy of α-cubebenoate isolated from Schisandra chinensis has been previously studied in three disease areas, namely inflammation, sepsis, and allergy, and its role in other diseases is still being explored.
Su Ji Bae +6 more
doaj +1 more source
3T3-L1 adipocytes display phenotypic characteristics of multiple adipocyte lineages [PDF]
Adipocyte, 2015 Differentiated 3T3-L1 adipocytes are a widely used in vitro model of white adipocytes. In addition to classical white and brown adipocytes that are derived from different cell lineages, beige adipocytes have also been identified, which have characteristics of both white and brown adipocytes.
Shona, Morrison, Sean L, McGee
openaire +2 more sources
Impaired release of Vitamin D in dysfunctional adipose tissue: New cues on Vitamin D supplementation in obesity [PDF]
, 2017 Context: Vitamin D accumulates in adipose tissue (AT) and vitamin D deficiency is frequent in obesity. Objective: We hypothesize that trafficking of vitamin D is altered in dysfunctional AT.
Azzena, Bruno +9 more
core +1 more source
Anti-Obesity Effect of α-Cubebenol Isolated from Schisandra chinensis in 3T3-L1 Adipocytes
Biomolecules, 2021 The efficacy of α-cubebenol isolated from Schisandra chinensis has been studied in several diseases, including cecal ligation, puncture challenge-induced sepsis, and degranulation of neutrophils.
Su Jin Lee +7 more
doaj +1 more source
Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response. [PDF]
, 2016 Adipocytes promote cancer progression and impair treatment, and have been shown to protect acute lymphoblastic leukemia (ALL) cells from chemotherapies. Here we investigate whether this protection is mediated by changes in oxidative stress.
Behan, James W +6 more
core +1 more source