Results 31 to 40 of about 43,182 (237)
Life, 2023 The increasing prevalence of obesity has prompted intensive research into understanding its role in pathogenesis and designing appropriate treatments. To determine the signals generated from the interaction of fat cells with a target organ, a reliable ...
Noshin Mubtasim, Lauren Gollahon
doaj +1 more source
Sinapic acid prevents adipogenesis by regulating transcription factors and exerts an anti-ROS effect by modifying the intracellular anti-oxidant system in 3T3-L1 adipocytes [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): In this study, we tested the hypothesis that sinapic acid (SA), a naturally occurring hydroxycinnamic acid found in vegetables, cereal grains, and oilseed crops with various biological activities suppresses adipogenesis in 3T3-L1 adipocytes
Cordelia John, Sumathy Arockiasamy
doaj +1 more source
Increased Oxidative Stress in Cultured 3T3-L1 Cells was Attenuated by Berberine Treatment
Natural Product Communications, 2015 The 3T3-L1 cell line is one of the most well-characterized and reliable models for studying adipocytes. Increased oxidative stress in accumulated fat was found in 3T3-L1 cells.
Shi-Fen Dong +5 more
doaj +1 more source
Molecules, 2018 Conflicting results for morusin activity during adipogenic differentiation are reported in 3T3-L1 adipocytes and cancer cells. To elucidate the influence of morusin on fat metabolism, their anti-obesity effects and molecular mechanism were investigated ...
Mi Rim Lee +10 more
doaj +1 more source
TC10 Is Regulated by Caveolin in 3T3-L1 Adipocytes
PLoS ONE, 2012 TC10 is a small GTPase found in lipid raft microdomains of adipocytes. The protein undergoes activation in response to insulin, and plays a key role in the regulation of glucose uptake by the hormone.TC10 requires high concentrations of magnesium in order to stabilize guanine nucleotide binding.
Dave Bridges +4 more
openaire +4 more sources
Effect of Cucumis sativus on Dysfunctional 3T3-L1 Adipocytes [PDF]
Scientific Reports, 2019 AbstractObesity is caused by lipid accumulation in adipose tissues inducing adipocyte dysfunction, characterized by insulin resistance, increased lipolysis, oxidative stress, and inflammation, leading to increased levels of adipokines. Herein the capacity of the subfractions (SFs) SF1, SF2, and SF3 from theCucumis sativusaqueous fraction and their ...
Marisol Méndez-Martínez +13 more
openaire +2 more sources
GALNT2 as a novel modulator of adipogenesis and adipocyte insulin signaling [PDF]
, 2019 Background/objectives: A better understanding of adipose tissue biology is crucial to tackle insulin resistance and eventually coronary heart disease and diabetes, leading causes of morbidity and mortality worldwide.
Antonucci, A. +6 more
core +1 more source
Effect of Hyperoside on the Inhibition of Adipogenesis in 3t3-L1 Adipocytes [PDF]
Acta Endocrinologica (Bucharest), 2019 The inhibition of adipocyte differentiation has a significant role on the prevention of obesity and obesity-associated complications.In this study, we aimed to detect whether hyperoside is able to inhibit the conversion of pre-adiposits into mature adiposits.3T3-L1 pre-adipocytes were stimulated so as to differentiate into mature adipocytes. Hyperoside
openaire +3 more sources
Insulin-responsive Aminopeptidase Trafficking in 3T3-L1 Adipocytes [PDF]
Journal of Biological Chemistry, 2000 The insulin-responsive aminopeptidase (IRAP/VP165/gp160) was identified originally in GLUT4-containing vesicles and shown to translocate in response to insulin, much like the glucose transporter 4 (GLUT4). This study characterizes the trafficking and kinetics of IRAP in exocytosis, endocytosis, and recycling to the membrane in 3T3-L1 adipocytes.
L A, Garza, M J, Birnbaum
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A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]
, 2015 The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam +16 more
core +2 more sources