Results 101 to 110 of about 4,980,683 (248)

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Expression of three Pparγ transcripts during adipogenesis of 3T3-L1 cells and mouse primary preadipocytes.

, 2013
3T3-L1 cells (A) and mouse primary preadipocytes (B) were cultured in the differentiation medium described in the “Materials and Methods”, harvested at the indicated periods, and analyzed by real-time RT-PCR. The values obtained for Pparγ1sv, Pparγ1, and
Yasuhiro Takenaka (423921), Yuichi Shinoda (423924), Shigehiro Katayama (423926), Takuya Awata (423925), Ikuo Inoue (423922), Masaaki Ikeda (323115), Takanari Nakano (423923)   +6 more
core   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Assessment of Adipocyte Transduction Using Different AAV Capsid Variants

Pharmaceuticals
Background/Objectives: Adeno-associated viruses (AAVs) are widely used as viral vectors for gene delivery in mammalian cells. We focused on the efficacy of the transduction of AAV2/5, 2/6, 2/8 and 2/9 expressing GFP in preadipocyte cells by live imaging ...
Stanislav Boychenko, Alina Abdullina, Viktor S. Laktyushkin, Andrew Brovin, Alexander D. Egorov   +4 more
doaj   +1 more source

Anti-adipocyte Differentiation Activity and Chemical Composition of Essential Oil from

Natural Product Communications, 2016
Artemisia annua L. essential oil (AAEO) has diverse properties including antibacterial, antioxidant, antinociceptive, and antimicrobial activities. However, the effect of AAEO on obesity remains to be investigated.
Dae Il Hwang, Kyung-Jong Won, Do-Yoon Kim, Seok Won Yoon, Joo-Hoon Park, Bokyung Kim, Hwan Myung Lee   +6 more
doaj   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Suppressive Effect of Neoxanthin on the Differentiation of 3T3-L1 Adipose Cells

Journal of Oleo Science, 2008
The objective of this study was to assess the suppressive effects of 13 naturally occurring carotenoids on the adipocyte differentiation of 3T3-L1. The relationship between carotenoid structure and suppressive effects was also examined. Treatment with neoxanthin significantly reduced lipid accumulation, as well as glycerol-3-phosphate dehydrogenase ...
Okada, Tomoko, Nakai, Miho, Maeda, Hayato, Hosokawa, Masashi, Sashima, Tokutake, Miyashita, Kazuo   +5 more
openaire   +3 more sources

Inhibition of the NR4A1‐mediated cell cycle checkpoint enhances hyperplastic adipogenesis and glucose homeostasis in obesity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity.
Wanning Qiao, Cun Ku, G. V. Naveen Kumar, Jonathan D. Brown, Manni Wu, Chenhang Li, Jiyu Xie, Huicui Meng, Litao Sun, Tao Zhou, Dong Liang, Yiwei Li, Matthew L. Steinhauser, Yang Zhang   +13 more
wiley   +1 more source

Human relaxin inhibits division but not differentiation of 3T3-L1 cells

Molecular and Cellular Endocrinology, 1990
For the first time, we demonstrate here the ability of human relaxin to block cell division. During the induction of differentiation of 3T3-L1 fibroblasts to adipocytes, the cells typically undergo two rounds of cell division followed by accumulation of lipid droplets and expression of insulin-stimulated glucose transport as the cells attain the ...
Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, U.S.A. ( host institution ), Pawlina, Wojciech, Larkin, Lynn H., Ogilvie, Susan, Frost, Susan C.   +4 more
openaire   +3 more sources

Ceramides, Particularly Those Containing Very‐Long‐Chain Saturated Fatty Acids, Are Independently Associated With the Triglyceride–Glucose Index in European Individuals With Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The triglyceride–glucose (TyG) index is associated with insulin resistance and cardiovascular disease (CVD), but the underlying mechanisms remain unclear. As ceramides are implicated in both insulin resistance and CVD, we investigated the association between the TyG index and plasma ceramides in individuals with Type 2 diabetes (T2D ...
Laure Carpentier, Damien Denimal, Alexia Rouland, Jean‐Michel Petit, Jean Paul Pais de Barros, Laurence Duvillard, Benjamin Bouillet, Bruno Vergès   +7 more
wiley   +1 more source