Results 111 to 120 of about 4,980,683 (248)
MetabolitesThe prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing. Obesity, insulin resistance, and lipid metabolic dysfunction are always accompanied by NAFLD. Celastrol modulates the Peroxisome proliferator-activated receptor γ (PPARγ) and
Mingzhu Luo +5 more
doaj +1 more source
WGEF inhibits adipogenesis in 3T3-L1 cells.
, 2013 A. Expression vectors with/without WGEF cDNA were individually transfected into 3T3-L1 cells, which were subsequently selected in G418-containing medium. Then, GFP-positive clones were analyzed. B.
Izuho Hatada (53660) +3 more
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Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling
The FEBS Journal, EarlyView.Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch +7 more
wiley +1 more source
Acceleration of Adipose Conversion of 3T3-L1 Cells by Dextran Sulfate
Bioscience, Biotechnology, and Biochemistry, 1994 When dextran sulfate was added at concentrations of 0.001% or 0.01% (w/v) to cultures of 3T3-L1 fibroblasts, their spontaneous adipose conversion was accelerated. The expression of a marker enzyme (glycerophosphate dehydrogenase) peaked on day 16 but later declined due to the cytotoxicity of dextran sulfate.
Ono, Masaaki, Kitagawa, Yasuo
openaire +1 more source
Human ENPP1 over-expression inhibits DMI-induced adipocyte maturation in 3T3-L1 cells.
, 2013 Human ENPP1 was over-expressed in 3T3-L1 using retrovirus transfection with CMV promoter. Panel A. ENPP1 protein content in cells containing vector only and in cells over-expressing human ENPP1 K121K or K121Q.
Mingui Fu (79114) +4 more
core +1 more source
Understanding extracellular vesicles in antiaging
Periodontology 2000, EarlyView.Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad +3 more
wiley +1 more source
Frontiers in Pharmacology, 2019 Background: Metabolic complications represent a common and serious problem associated with HIV infection and combined Antiretroviral Therapy (cART). Alterations in body fat distribution are associated with significantly increased risks of (i) metabolic ...
Elena Bresciani +10 more
doaj +1 more source
retinoic acid‐induced reduction of adipogenesis in 3T3‐L1 cells
, 2015 Vitamin A has preventive effects on obesity. All-trans retinoic acid (ATRA), the active form of vitamin A, inhibits lipid accumulation in 3T3-L1 cells in an experimental adipogenesis model.
Chiaki Sagara +5 more
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The Journal of Physiology, EarlyView.Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos +7 more
wiley +1 more source
Expression of adipogenic transcription factors in 3T3-L1 cells.
, 2016 3T3-L1 pre-adipocytes were differentiated in DMI and DMII for 12 days. KLF5 (a), C/EBPα (b) and PPARγ2 (c) mRNA (upper panels) and protein (lower panels) in 3T3-L1 cells was analyzed by qRT-PCR (upper panels) or immunoblot (lower panels) at the indicated
Stefan Frank (148010) +3 more
core +1 more source