Results 61 to 70 of about 4,897,037 (304)

Wireless Precise Manipulation of Tumor Spheroids Using a Millirobot Controlled by Permanent Magnetic Traps

Advanced Robotics Research, EarlyView.
A magnetic donut‐like millirobot is developed for label‐free pick‐and‐place of a tumor spheroid wirelessly controlled by a magnetic trap. Spheroids are important 3D multicellular culture systems that recapitulate key structural and functional features of native tissues.
Yue Gao, Moonkwang Jeong, Anni G. Muñoz, Ann‐Sophia Müller, Fangchao Long, Shengqiang Zhou, Juntian Qu, Leoni A. Kunz‐Schughart, Tian Qiu   +8 more
wiley   +1 more source

Brd2 inhibits adipogenesis via the ERK1/2 signaling pathway in 3T3-L1 adipocytes.

PLoS ONE, 2013
Bromodomain-containing protein 2 (Brd2) is a nuclear serine/threonine kinase involved in transcriptional regulation. In 3T3-L1 adipocytes, Brd2 normally co-represses PPARγ (peroxisome proliferator-activated receptor gamma) and inhibits adipogenesis. Here,
Kun Zang, Jingyu Wang, Miaofang Dong, Ruixin Sun, Yuxiong Wang, Yinong Huang, Xiaoxia Liu, Yimin Li, Fangnian Wang, Min Yu   +9 more
doaj   +1 more source

Inhibition of Col6a5 Improve Lipid Metabolism Disorder in Dihydrotestosterone-Induced Hyperandrogenic Mice

Frontiers in Cell and Developmental Biology, 2021
Hyperandrogenism is a key pathological feature of polycystic ovarian syndrome (PCOS). Excess androgen can lead to PCOS-like cell hypertrophy in the ovaries and adipose tissue of rodents.
Li-Feng Sun, Ya-Li Yang, Ya-Li Yang, Mei-Yue Wang, Mei-Yue Wang, Hua-Shan Zhao, Hua-Shan Zhao, Tian-xia Xiao, Meng-Xia Li, Bao-Bei Wang, Chen Huang, Chen Huang, Pei-Gen Ren, Pei-Gen Ren, Jian V. Zhang, Jian V. Zhang   +15 more
doaj   +1 more source

Inhibition of adipogenesis by Tempol in 3T3-L1 cells [PDF]

Free Radical Biology and Medicine, 2010
Obesity is highly associated with an increased risk of serious health conditions including hypertension, cardiovascular disease, diabetes, and cancer. Changes in redox status with increased oxidative stress have been linked with obesity. Previous studies have shown that administration of the antioxidant Tempol in the food of mice prevents obesity ...
Yuval, Samuni, John A, Cook, Rajani, Choudhuri, William, Degraff, Anastasia L, Sowers, Murali C, Krishna, James B, Mitchell   +6 more
openaire   +2 more sources

Angiotensinogen gene expression in 3T3-L1 cells

, 1989
It has previously been established that angiotensinogen mRNA is present in brown and white adipose tissue of the rat. To determine whether angiotensinogen gene expression is present in adipocytes as compared with other cell elements, we have examined ...
T. W. Sturgill, M. J. Peach, J. A. Saye, K. R. Lynch, L. A. Cassis   +4 more
core   +1 more source

Additional experiments supporting that FABP4 regulates PPARG expression and adipogenesis in 3T3-F442A cells.

, 2022
(A, B) The analysis of sequencing results for the 3T3-F442A FABP4-KO (A) and FABP4/FABP5 DBKO (B) clones used in Fig 1. (C, D) Knockout of FABP4 and FABP5 impairs adipogenesis in 3T3-FF42A preadipocyte cells induced to differentiate by the standard ...
Atefeh Rabiee (8672796), Zahra Bahrami-Nejad (14216460), Stefan Tholen (2618575), Sanjeev Sharma (1762987), Michael L. Zhao (14216466), Zhi-Bo Zhang (14216463), Mary N. Teruel (14216472), Fredric B. Kraemer (14216469)   +7 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Reactive oxygen species and senescence modulatory effects of rice bran extract on 4T1 and NIH-3T3 cells co-treatment with doxorubicin

Asian Pacific Journal of Tropical Biomedicine, 2021
Objective: To determine the effect of rice bran extract (RBE) in combination with doxorubicin on 4T1 triple-negative breast cancer cells and NIH-3T3 cells. Methods: RBE was obtained by maceration with n-hexane.
Ummi Maryam Zulfin, Ave Rahman, Mila Hanifa, Rohmad Yudi Utomo, Sari Haryanti, Edy Meiyanto   +5 more
doaj   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source