Results 81 to 90 of about 775 (125)

Nuclear receptors CAR and PXR as cardiometabolic regulators

Pharmacological Research
The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) were initially described as xenobiotic sensors, but an increasing number of studies have linked their activity to other important physiological processes including glucose and lipid
Janne Hukkanen, Jenni Küblbeck, Jukka Hakkola, Jaana Rysä   +3 more
doaj   +1 more source

Pregnancy Increases CYP3A Enzymes Activity as Measured by the 4β-Hydroxycholesterol/Cholesterol Ratio. [PDF]

Int J Mol Sci, 2022
Mlugu EM, Minzi OM, Kamuhabwa AAR, Diczfalusy U, Aklillu E.   +4 more
europepmc   +1 more source

Utility of endogenous 4β-hydroxycholesterol as a biomarker to assess cytochrome P 450 3A (CYP3A) activity: not quite ready for prime time. [PDF]

Eur J Clin Pharmacol, 2022
Tung NP, Ma JD.
europepmc   +1 more source

Modeling and simulation of the endogenous CYP3A induction marker 4β-hydroxycholesterol during enasidenib treatment

Clinical Pharmacology: Advances and Applications, 2019
Yan Li,1 Jamie N Connarn,1 Jian Chen,2 Zeen Tong,2 Maria Palmisano,1 Simon Zhou1 1Translational Development and Clinical Pharmacology, Celgene Corporation, Summit, NJ, USA; 2Non-Clinical Development, Celgene Corporation, Summit, NJ, USA Background ...
Li Y, Connarn JN, Chen J, Tong Z, Palmisano M, Zhou S   +5 more
doaj  

Response to: "Utility of endogenous 4β-hydroxycholesterol as a biomarker to assess cytochrome P 450 3A (CYP3A) activity: not quite ready for prime time". [PDF]

Eur J Clin Pharmacol, 2022
Kvitne KE, Hole K, Molden E, Robertsen I.   +3 more
europepmc   +1 more source

the NEMESIS project's quest for novel biomarkers, evidence on adverse effects, and efficient methodologies [PDF]

publishersversionpublishe
Afantitis, Antreas, Cnop, Miriam, Fortino, Vittorio, Fyhrquist, Nanna, Godinho, Cristina, Greco, Dario, Grimalt, Joan o, Guzman, Tereso j, Hakkola, Jukka, Hakomäki, Henriikka, Harlid, Sophia, Honkakoski, Paavo, Hukkanen, Janne, Küblbeck, Jenni, Lauschke, Volker m, Levonen, Anna-Liisa, Nawrot, Tim, Pitkänen, Sini, Rysä, Jaana, Saarimäki, Laura aliisa, Sawatani, Toshiaki, Tardon, Adonina, Vallier, Ludovic, Viegas, Susana, Vinnars, Marie-Therese, Wincent, Emma   +25 more
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Serum 4β-hydroxycholesterol increases during fluconazole treatment. [PDF]

Eur J Clin Pharmacol, 2021
Lütjohann D, Stellaard F, Kerksiek A, Lötsch J, Oertel BG.   +4 more
europepmc   +1 more source

Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss [PDF]

, 2018
Advanced age-related macular degeneration (AMD), the leading cause of blindness among people over 50 years of age, is characterized by atrophic neurodegeneration or pathologic angiogenesis.
Apte, Rajendra S, Ban, Norimitsu, Choudhary, Mayur, Dong, Zhenyu, Lee, Tae Jun, Lekwuwa, Michael, Lin, Jonathan B, Malek, Goldis, Ory, Daniel S, Santeford, Andrea, Sene, Abdoulaye   +10 more
core   +1 more source

CYP3A Activity in End-of-Life Cancer Patients Measured by 4β-Hydroxycholesterol/cholesterol Ratio, in Men and Women. [PDF]

Cancers (Basel), 2021
Bergström H, Helde Frankling M, Klasson C, Lövgren Sandblom A, Diczfalusy U, Björkhem-Bergman L.   +5 more
europepmc   +1 more source

Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range. [PDF]

Eur J Clin Pharmacol, 2022
Eide Kvitne K, Hole K, Krogstad V, Wollmann BM, Wegler C, Johnson LK, Hertel JK, Artursson P, Karlsson C, Andersson S, Andersson TB, Sandbu R, Hjelmesæth J, Skovlund E, Christensen H, Jansson-Löfmark R, Åsberg A, Molden E, Robertsen I.   +18 more
europepmc   +1 more source