Results 81 to 90 of about 11,638,573 (298)
Preliminary structure-activity relationship studies on some novel s-substituted aliphatic analogues of 5-{1-[(4- chlorophenyl) sulfonyl]-3-piperidinyl}-1, 3, 4-oxadiazol-2-yl sulfide [PDF]
, 2016 Purpose: To study the structure-activity relationships of synthetic multifunctional sulfides through evaluation of lipoxygenase and anti-bacterial activities.Methods: S-substituted derivatives of the parent compound 5-(1-(4- chlorophenylsulfonyl ...
Abbasi, M. Athar +5 more
core +2 more sources
Antibiotics, 2021 Staphylococcusaureus is an important opportunistic pathogen that causes many infections in humans and animals. The inappropriate use of antibiotics has favored the diffusion of methicillin-resistant S.
E. Buommino +5 more
semanticscholar +1 more source
Tổng hợp và đánh giá hoạt tính kháng khuẩn của một số dẫn xuất naphthalene-1,3,4-oxadiazole
Tạp chí Khoa học Đại học Cần Thơ, 2018 1,3,4-Oxadiazole có nhiều hoạt tính sinh học bao gồm kháng khuẩn, kháng nấm, kháng viêm, giảm đau, hạ lipid máu, kháng ung thư, chống co giật, chống đái tháo đường, kháng virus và chống loét.
Nguyễn Thị Cẩm Hồng +7 more
doaj +1 more source
Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.Initial screening of the synthesized compounds revealed that compounds MK175 and MK169 inhibited LPS‐induced IL‐1β release in human aortic smooth muscle cells. ABSTRACT Proinflammatory cytokine interleukin (IL)‐1β is a key mediator of the inflammatory response in atherosclerosis.
Dimitra T. Pournara +6 more
wiley +1 more source
Medical Laboratory Journal, 2021 Background and objectives: Antibiotic resistance is a major public health challenge. The pervasive antibiotic misuse can lead to increased antibiotic resistance.
Nakisa Zarrabi Ahrabi +2 more
doaj
Synthesis and antimicrobial evaluation of some 2,5 disubstituted 1,3,4-oxadiazole derivatives
Research in Pharmaceutical Sciences, 2017 1,3,4-oxadiazoles are interesting compounds because of their valuable biological effects such as cytotoxic, antibacterial, antifungal, and anti-tubercular activities.
Elham Jafari +3 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 1, January 2026.Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri +14 more
wiley +1 more source
A Hybrid Photo/Biocatalytic System for the Sustainable Synthesis of L‐Alanine From Urea and Pyruvate
ChemSusChem, Volume 19, Issue 2, January 2026.We present a visible‐light driven photo‐biocatalytic system combining urease (URE), L‐alanine dehydrogenase (AlDH) and visible‐light driven nicotinamide adenine dinucleotide (NADH) regeneration system consisting of triethanolamine (TEOA), zinc meso‐tetra(4‐sulfonatophenyl)porphyrin tetrasodium salt (ZnTPPS4‐) and [Cp*Rh(bpy)(H2O)]2+.
Kyosuke Yamada, Yutaka Amao
wiley +1 more source
5-[1-(3,4-Dichlorophenoxy)ethyl]-1,3,4-oxadiazole-2(3H)-thione hemihydrate
Acta Crystallographica Section E, 2009 In the title compound, C10H8Cl2N2O2S·0.5H2O, the atoms in the oxadiazole ring are essentially coplanar (r.m.s. deviation 0.010 Å).
Tashfeen Akhtar +3 more
doaj +1 more source
Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry
ChemistryOpen, Volume 15, Issue 1, January 2026.Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten +5 more
wiley +1 more source