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SYNTHESIS OF MONO-SUBSTITUTED AND SIMMETRICALLY 2, 5-DISUBSTITUTED 1, 3, 4-OXADIAZOLES [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2012
In recent years 1,3,4-oxadiazoles have received considerable attention due to their wide range of biological activities and practical importance. They form an important class of fi ve-member heterocyclic compounds with a variety of derivatives.
Z. Ribcovskaia, F. Macaev
doaj   +3 more sources

Syntheses, Evaluation and Characterization of Some 1, 3, 4-Oxadiazoles as Antimicrobial Agents [PDF]

E-Journal of Chemistry, 2009
1,3,4-Oxadiazoles show various biological activities and have been synthesized from different compounds. 1,3,4-oxadiazole is popularly known for its antimicrobial, anti-inflammatory, pesticidal and antihypertensive activities etc.
Niti Bhardwaj, S. K. Saraf, Pankaj Sharma, Pradeep Kumar   +3 more
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Synthesis and Characterization of Novel 2-Alkyl-1,3,4-Oxadiazoles Containing a Phenylazo Group [PDF]

Molecules
An efficient method for the synthesis of novel phenylazo-containing moieties is described. The derivatives of 5-(4-(phenyldiazenyl)phenyl)-1,3,4-oxadiazole, substituted at position 2 of the heterocyclic scaffold with alkyl groups of different chain ...
Sebastian Górecki, Agnieszka Kudelko
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Polymers Containing 1, 3, 4-Oxadiazole Rings for Advanced Materials

Memoirs of the Scientific Sections of the Romanian Academy, 2011
This paper presents the synthesis, properties and potential applications of new polymers containing 1, 3, 4-oxadiazole rings, tacking into account the requirements of the modern technologies. Two classes of polymers containing oxadiazole rings were approached: polyamides and polyimides.
Mariana-Dana Damaceanu, Radu-Dan Rusu, Maria Bruma   +2 more
openaire   +2 more sources

Molecular Structure, Matrix-Isolation IR Spectrum and UV-Induced Transformations of 2-Amino-5-(4-Methoxyphenyl)-1,3,4-Oxadiazole [PDF]

Molecules
The photochemistry of 1,3,4-oxadiazoles remains poorly understood, despite their recognized importance in medicinal chemistry and materials science. In this work, we report a detailed matrix-isolation study of 2-amino-5-(4-methoxyphenyl)-1,3,4-oxadiazole,
İsa Sıdır, Susy Lopes, Rui Fausto, A. J. Lopes Jesus   +3 more
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3-(3-Azabicyclo[2, 2, 1]heptan-2-yl)-1,2,4-oxadiazoles as Novel Potent DPP-4 Inhibitors to Treat T2DM [PDF]

Pharmaceuticals
Background: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease with global implications, necessitating effective management strategies.
Tatiana V. Zinevich, Ivan O. Maslov, Olga G. Kirichenko, Sergey V. Shorshnev, Maxim A. Gureev, Fedor M. Dolgushin, Yuri B. Porozov, Vladimir M. Trukhan   +7 more
doaj   +2 more sources

Tandem diazotization/cyclization approach for the synthesis of a fused 1,2,3-triazinone-furazan/furoxan heterocyclic system [PDF]

Beilstein Journal of Organic Chemistry
A straightforward protocol for the synthesis of a previously unknown [1,2,5]oxadiazolo[3,4-d][1,2,3]triazin-7(6H)-one heterocyclic system was developed. The described approach is based on tandem diazotization/azo coupling reactions of (1,2,5-oxadiazolyl ...
Yuri A. Sidunets, Valeriya G. Melekhina, Leonid L. Fershtat   +2 more
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5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study

Pharmaceuticals, 2022
2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors are used, e.g., to treat dementias and myasthenia ...
Václav Pflégr, Šárka Štěpánková, Katarína Svrčková, Markéta Švarcová, Jarmila Vinšová, Martin Krátký   +5 more
doaj   +1 more source

2D-QSAR study of synthesized novel derivatives of 1,3,4- Oxadiazoles as anti-inflammatory activity

BLDE University Journal of Health Sciences, 2020
Oxadiazole is a five-membered heterocyclic compound containing oxygen and two nitrogen atoms at C-1, C-3 and C-4 positions respectively. These derivatives are synthesized by both conventional as well as microwave-assisted.
M Somashekhar, R B Kotnal
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Expeditious synthesis of 1,3,4-oxadiazole derivatives via sydnones [PDF]

Journal of the Serbian Chemical Society, 2008
The clean cyclization of chalcones (1a–c/2a–c) with hydrazine hydrate under microwave irradiation afforded pyrazolines derivatised with sydnone (3d–i/4d–i), which underwent 1,3-dipolar cyclo-addition with acetic anhydride to form pyrazolines appended ...
D. G. BHADREGOWDA, B. S. SUDHA, RAVINDRA R. KAMBLE   +2 more
doaj   +3 more sources