Results 11 to 20 of about 11,419,926 (368)

Synthesis and characterization of some novel 1,2,4-triazoles, 1,3,4-thiadiazoles and Schiff bases incorporating imidazole moiety as potential antimicrobial agents [PDF]

open access: yesActa Pharmaceutica, 2015
(1,4,5-Triphenylimidazol-2-yl-thio)butyric acid hydrazide (3) was obtained via alkylation of 1,4,5-triphenylimidazol-2- thiol (1) with ethylbromobutyrate, followed by addition of hydrazine hydrate.
M. Aouad   +4 more
semanticscholar   +4 more sources

Determination of the pKa value of some 1,2,4-triazol derivatives in forty seven different solvents using semi-empirical quantum methods (PM7, PM6, PM6-DH2, RM1, PM3, AM1, and MNDO) by MOPAC computer program [PDF]

open access: yes, 2023
In this study, we calculated the enthalpy (?H, kcal/mol), entropy (?S, cal/K.mol) and free energy (?G, kcal/mol) thermodynamic values of each molecule for forty-seven different solvent media according to semi-empirical quantum methods (PM7, PM6, PM6-DH2,
Erdoğan, Naciye   +2 more
core   +1 more source

1,2,3-Triazole-4(5)-amines – Convenient Synthetic Blocks for the Construction of Triazolo-Annulated Heterocycles

open access: yesЖурнал органічної та фармацевтичної хімії, 2022
Aim. To analyze and summarize the synthetic potential of 1,2,3-triazole-4(5)-amines as efficient building blocks in the synthesis of triazolo-annulated pyridine, azine and azepine systems. Results and discussion.
Natalia O. Syrota   +3 more
doaj   +1 more source

Design and Synthesis of New 5-aryl-4-Arylethynyl-1H-1,2,3-triazoles with Valuable Photophysical and Biological Properties

open access: yesMolecules, 2021
Cu-catalyzed 1,3-dipolar cycloaddition of methyl 2-azidoacetate to iodobuta-1,3-diynes and subsequent Suzuki-Miyaura cross-coupling were used to synthesize new triazoles derivatives: 5-aryl-4-arylethynyl-1H-1,2,3-triazoles. Investigation of their optical
Mariia M. Efremova   +4 more
doaj   +1 more source

Effects of 1, 2, 4-Triazole Additive on PEM Fuel Cell Conditioning [PDF]

open access: yesMembranes, 2020
Melt processing is one of the essential technologies for the mass production of polymer electrolyte membranes (PEM) at low cost. Azoles have been widely used in PEM to improve their conductivity at a relatively low humidity and recently as bifunctional additives in a melt blowing processing for PEM mass production.
Zhao, Nana   +4 more
openaire   +4 more sources

Discovery of a new class of triazole based inhibitors of acetyl transferase KAT2A

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2022
We have recently developed a new synthetic methodology that provided both N-aryl-5-hydroxytriazoles and N-pyridine-4-alkyl triazoles. A selection of these products was carried through virtual screening towards targets that are contemporary and validated ...
Roberta Pacifico   +9 more
doaj   +1 more source

Thermal Rearrangement of Allyl Substituted Unsymmetric 4H-1,2,4-Triazoles to the Corresponding 1H-1,2,4-triazoles

open access: yesMolecules, 2001
A series of neat 4-(2-alkenyl) substituted 5-methyl-3-phenyl-4H-1,2,4-triazoles were thermolyzed at 320 oC producing a rearrangement products, of which the regioisomeric 1- and 2-substituted triazoles were the main products.
Per H.J. Carlsen   +2 more
doaj   +1 more source

5-Formyltriazoles as Valuable Starting Materials for Unsymmetrically Substituted Bi-1,2,3-Triazoles

open access: yesFrontiers in Chemistry, 2020
Herein, we present the first synthetic methodologies toward non-symmetrical 5,5′-C, C-linked bi-1,2,3-triazoles starting from 5-formyl-1,2,3-triazole via two related pathways.
Robby Vroemans   +3 more
doaj   +1 more source

Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1 [PDF]

open access: yes, 2011
We describe the use of iterative in situ click chemistry to design an Akt-specific branched peptide triligand that is a drop-in replacement for monoclonal antibodies in multiple biochemical assays.
Agnew, Heather D.   +12 more
core   +2 more sources

Synthesis Of 2-Benzamidomethyl-5-Substituted Amino-1,3,4-Thiadiazoles-2,5-Disubstituted 1,3,4-Oxadiazole and 4,5-Disubstituted 1,2,4-Triazole-3-Thiol [PDF]

open access: yesمجلة التربية والعلم, 2012
In this paper the synthesis of some substituted 1,3,4-oxadiazoles , 1,3,4-thiadiazoles and 1,2,4-triazoles starting from amino acid and benzoyl chloride is reported.
K. M. Daoud, A. N. Ali, A. A. Ahmed
doaj   +1 more source

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