Results 41 to 50 of about 11,548,212 (369)

Discovery of antiproliferative and anti-FAK inhibitory activity of 1,2,4-triazole derivatives containing acetamido carboxylic acid skeleton [PDF]

, 2021
Small molecule inhibitors of the focal adhesion kinase are regarded as promising tools in our armamentarium for treating cancer. Here, we identified four 1,2,4-triazole derivatives that inhibit FAK kinase significantly and evaluated their therapeutic ...
Abd El-Hafeez, Amer Ali, Abdelhamid, Dalia, Abuo-Rahma, Gamal El-Din A, Ahmed, Esam R, Ghosh, Pradipta, Hayallah, Alaa M, Mustafa, Muhamad   +6 more
core   +1 more source

Synthesis, Evaluation and Characterization of Some 1,3,4-Triazole-2-one Derivatives as Antimicrobial Agents

E-Journal of Chemistry, 2012
A series of novel compounds like 3[(phenyl substituted)-5-methyl-1(Benzosulphonylamine)]-1,3,4-triazole-2-ones II(a-f) were synthesized by treating 4-amino-1-phenyl-3-methyl-5-oxo-1,2,4-triazoles with benzene sulphonyl chloride using pyridine as solvent.
Mahabaleshwaraiah Neelgundmath, Oblennavar Kotresh   +1 more
doaj   +1 more source

Design, synthesis, characterization and computational docking studies of novel sulfonamide derivatives [PDF]

This study reports three novel sulfonamide derivatives 4-Chloro-N-[(4-methylphenyl) sulphonyl]-N-propyl ben- zamide (1A), N-(2-hydroxyphenyl)-4-methyl benzene sulfonamide (1B) and 4-methyl-N-(2-nitrophenyl) ben- zene sulfonamide (1C).
Ashiq, Ayesha, Bokhari, Saleem Ahmed, Khalid, Rana Rehan, Maryam, Arooma, Qureshi, Fahim Ashraf, Rauf, Sadaf Abdul, Saleem, Hira, Siddiqi, Abdul Rauf   +7 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Analysis of the relationship between the predicted biological activity and the chemical structure of S-derivatives of 5-(5-bromofuran-2-yl)-4R-1,2,4-triazole-3-thiols

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2021
1,2,4-Triazole derivatives are actively used as components in the development of new drugs, plant protection products, polymeric materials, anti-corrosion agents and etc.
O. A. Bigdan
doaj   +1 more source

Anti-inflammatory and antinociceptive evaluation of newly synthesized 4-(substituted ethanoyl) amino-3-mercapto-5-(4-methoxy) phenyl-1,2,4-triazoles

Journal of Pharmacy and Bioallied Sciences, 2011
Introduction: 1,2,4-triazoles and its derivatives have been reported to possess anti-inflammatory, analgesic, antimicrobial, anticancer, antitumor, antitubercular, anticonvulsant, openers of Ca-activated potassium (Maxi-K) channels, antiviral properties,
N. Upmanyu, J. Gupta, K. Shah, P. Mishra
semanticscholar   +1 more source

1,2,4-TRIAZOLES: SYNTHETIC STRATEGIES AND PHARMACOLOGICAL PROFILES [PDF]

, 2014
Multicomponent, solid-phase, microwave and grinding methods are the constructive modes in the sustainable synthesis of 1, 2, 4-triazoles and such reactions have attracted enormous interest in recent years.
B., Namratha, Gaonkar, Santosh L.
core  

Studies on Potential Pesticides Part-XII [PDF]

, 2014
Fifteen N/sup 1/-(4-Nitrophenoxyacetyl)N/sup 4/-aryl/cryclohexyl-3-thiosemicarbazide, eleven 3-(4-Nitrophenoxymethyl)-4-aryl/cyclohexyl-5-mercapto1,2,4-triazoles and four 2-Arylamino-5-(4-Nitrophenoxymethyl)-1,3,4-oxadiazole derivatives were prepared and
Misra, Hemant K., Sen, Anil K.
core   +2 more sources

Ionic Metal Poly(heptazine Imides) and Single‐Atoms Interplay: Engineered Stability and Performance for Photocatalysis, Photoelectrocatalysis and Organic Synthesis

Advanced Functional Materials, EarlyView.
Poly(heptazine) imides (PHIs), a crystalline carbon nitride subclass, intercalate metals to deliver high stability, tunable electronics, and efficient charge separation. These features enable solar‐driven applications such as hydrogen evolution, CO₂ reduction, and organic synthesis.
Gabriel A. A. Diab, Izadora F. Reis, Chong Wang, Diandra Barreto, Oleksandr Savateev, Ivo F. Teixeira, Pablo Jiménez‐Calvo   +6 more
wiley   +1 more source

Fast and Efficient Synthesis of Fluoro Phenyl 1,2,3-Triazoles via Click Chemistry with Ultrasound Irradiation and Their Biological Efficacy Against Candida albicans

Organics
Several fluoro phenyl triazoles were synthesized using click chemistry between fluoro phenyl azides and phenyl acetylene. Under ultrasound irradiation, this synthetic procedure was performed with Cu (I) in the presence of 1,10-phenanthroline.
Elisa Leyva, Johana Aguilar, Silvia E. Loredo-Carrillo, Ismael Acosta-Rodríguez   +3 more
doaj   +1 more source