Results 81 to 90 of about 28,423 (282)
Study acute toxicity of 4-(R-amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol in vivo
Фармацевтичний журнал, 2018 Typically, the system is already known are used as the core for a new substance, which have already proved themselves as potential drugs. So one of these is 1,2,4-triazole ring.
A. A. Safonov
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Irreversible reaction of 3-amino-1:2:4-triazole and related inhibitors with the protein of catalase [PDF]
, 1960 E. Margoliash +2 more
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Advanced Science, EarlyView.This study reveals that Arabidopsis telomere repeat binding proteins (TRBs) form two closely related complexes. These complexes mediate H3K4me3 demethylation and transcriptional repression through a positive feedback loop and cooperate with PEAT and PRC2 complexes to regulate multiple histone modifications and gene expression across the genome ...
Qi Wang +7 more
wiley +1 more source
Studies on Methylated 1,2,3-Triazoles. VI. Preparation of 2-Methyl Substituted 4-Hydroxy-1,2,3-triazoles. [PDF]
, 1969 Mikael Begtrup +5 more
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Advanced Science, EarlyView.Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao +4 more
wiley +1 more source
Studies on Methylated 1,2,3-Triazoles. IV. Preparation of 1-Methyl-4-hydroxy-1,2,3-triazole. [PDF]
, 1967 Mikael Begtrup +8 more
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Advanced Science, EarlyView.A well‐designed experimental model reveals a trade‐off between intrinsic activity and catalytic site density in performance optimization, due to inherent diffusion resistance arising from substrate adsorption at catalytic sites. Abstract Enhancing intrinsic activity and increasing catalytic site density are two widely employed strategies to improve ...
Guo‐Ying Han +13 more
wiley +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015 The aim of research. Modern drugs must have certain characteristics, such as low toxicity and high efficiency. Special attention should be given to esthers of 2-(1,2,4-triazoles-3-iltio)acetic acids.
V. A. Salionov
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Dual Disruption of the Immune Cytokine Spätzle Facilitates Fungal Infection of Diverse Insect Hosts
Advanced Science, EarlyView.The Toll pathway is essential for insect defense against fungal pathogens. This works reports that fungal parasites employ two divergent virulent effectors to target the Toll receptor ligand Spätzle: a metalloprotease degrading it and a hairpin‐like effector hijacking it to block signal transduction. This dual strategy enables the fungus to kill a wide
Shuangxiu Song +7 more
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Angewandte Chemie, EarlyView.A dimethylsulfoniopropionate lyase (DddK) was identified as an efficient aza‐Michaelase for the addition of amines to acrylate. Screening 74 amines with wild‐type DddK and its W26G variant yielded N‐substituted and N,N‐disubstituted β‐amino acids in 30%–93% isolated yield.
Diletta Arceri +5 more
wiley +2 more sources