Crystal structure of 7,8-dihydroneopterin triphosphate epimerase [PDF]
Structure, 1999 Dihydroneopterin triphosphate (H2NTP) is the central substrate in the biosynthesis of folate and tetrahydrobiopterin. Folate serves as a cofactor in amino acid and purine biosynthesis and tetrahydrobiopterin is used as a cofactor in amino acid hydroxylation and nitric oxide synthesis.
Christoph Haußmann +6 more
core +6 more sources
A systematic review and meta-analysis of neopterin in rheumatic diseases [PDF]
Frontiers in Immunology, 2023 IntroductionNovel biomarkers of inflammation and oxidative stress might enhance the early recognition, management, and clinical outcomes of patients with rheumatic diseases (RDs).
Arduino A. Mangoni +2 more
doaj +5 more sources
Neopterin/7,8-dihydroneopterin is elevated in Duchenne muscular dystrophy patients and protects mdx skeletal muscle function. [PDF]
Exp Physiol, 2018 New Findings What is the central question of this study? We examined whether the macrophage‐synthesized antioxidant 7,8‐dihydroneopterin was elevated in Duchenne muscular dystrophy (DMD) patients. We then examined whether 7,8‐dihydroneopterin could protect dystrophic skeletal mouse muscle from eccentric contraction‐induced force loss and improve ...
Lindsay A +4 more
europepmc +6 more sources
Neopterin and 7,8-dihydroneopterin are generated within atherosclerotic plaques
Pteridines, 2015 Plasma neopterin correlates with the level of cardiovascular disease. Neopterin is the oxidation product of 7,8-dihydroneopterin, which is released by γ-interferon-stimulated macrophages. 7,8-Dihydroneopterin is a potent antioxidant, which inhibits lipid
Janmale Tejraj +7 more
doaj +4 more sources
Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients. [PDF]
PLoS ONE, 2021 Knee and hip arthroplasty are common surgeries within an aging population. Some data has suggested that knee arthroplasty is more traumatic to the body than hip arthroplasty due to the increased complexity and load bearing nature of the joint.
Gregory Baxter-Parker +6 more
doaj +4 more sources
Potential to inhibit growth of atherosclerotic plaque development through modulation of macrophage neopterin/7,8-dihydroneopterin synthesis. [PDF]
Br J Pharmacol, 2008 The rise in plasma neopterin observed with increasing severity of vascular disease is a strong indicator of the inflammatory nature of atherosclerosis. Plasma neopterin originates as the oxidation product of 7,8‐dihydroneopterin secreted by γ‐interferon stimulated macrophages within atherosclerotic plaques.
Gieseg SP, Crone EM, Flavall EA, Amit Z.
europepmc +6 more sources
Pteridines, 2020 Introduction: Neopterin and 7,8-dihydroneopterin are used as biomarkers of oxidative stress and inflammation, but the effect of kidney function on these measurements has not been extensively explored.
Baxter-Parker Gregory +6 more
doaj +2 more sources
Neopterin, the Cell-Mediated Immune Response Biomarker, in Inflammatory Periodontal Diseases: A Narrative Review of a More than Fifty Years Old Biomarker [PDF]
Biomedicines, 2023 Neopterin is a biomarker of the activation of cellular immunity. The purpose of this review is to summarise neopterin metabolism, methods of its detection, and its role in inflammation, focusing on periodontal inflammatory diseases.
Ondrej Heneberk +2 more
doaj +2 more sources
Study on potential markers for diagnosis of renal cell carcinoma by serum untargeted metabolomics based on UPLC-MS/MS [PDF]
Frontiers in Physiology, 2022 Objective: Renal cell carcinoma (RCC) is the most common malignancy of the kidney. However, there is no reliable biomarker with high sensitivity and specificity for diagnosis and differential diagnosis. This study aims to analyze serum metabolite profile
Jun Wang +7 more
doaj +2 more sources
FolX from Pseudomonas aeruginosa is octameric in both crystal and solution [PDF]
FEBS Letters, Volume 586, Issue 8, Page 1160-1165, April 24, 2012., 2012 FolX and FolX bind by x ray scattering (View interaction)
Mads Gabrielsen +4 more
wiley +3 more sources