Neopterin/7,8-dihydroneopterin is elevated in Duchenne muscular dystrophy patients and protects mdx skeletal muscle function. [PDF]
Exp Physiol, 2018 What is the central question of this study? We examined whether the macrophage‐synthesized antioxidant 7,8‐dihydroneopterin was elevated in Duchenne muscular dystrophy (DMD) patients. We then examined whether 7,8‐dihydroneopterin could protect dystrophic
Lindsay A +4 more
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Neopterin and 7,8-dihydroneopterin are generated within atherosclerotic plaques
Pteridines, 2015 Plasma neopterin correlates with the level of cardiovascular disease. Neopterin is the oxidation product of 7,8-dihydroneopterin, which is released by γ-interferon-stimulated macrophages. 7,8-Dihydroneopterin is a potent antioxidant, which inhibits lipid
Janmale Tejraj +7 more
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Potential to inhibit growth of atherosclerotic plaque development through modulation of macrophage neopterin/7,8-dihydroneopterin synthesis. [PDF]
Br J Pharmacol, 2008 The rise in plasma neopterin observed with increasing severity of vascular disease is a strong indicator of the inflammatory nature of atherosclerosis. Plasma neopterin originates as the oxidation product of 7,8‐dihydroneopterin secreted by γ‐interferon stimulated macrophages within atherosclerotic plaques.
Gieseg SP, Crone EM, Flavall EA, Amit Z.
europepmc +5 more sources
A systematic review and meta-analysis of neopterin in rheumatic diseases [PDF]
Frontiers in Immunology, 2023 IntroductionNovel biomarkers of inflammation and oxidative stress might enhance the early recognition, management, and clinical outcomes of patients with rheumatic diseases (RDs).
Arduino A. Mangoni +2 more
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Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients. [PDF]
PLoS ONE, 2021 Knee and hip arthroplasty are common surgeries within an aging population. Some data has suggested that knee arthroplasty is more traumatic to the body than hip arthroplasty due to the increased complexity and load bearing nature of the joint.
Gregory Baxter-Parker +6 more
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Pteridines, 2020 Introduction: Neopterin and 7,8-dihydroneopterin are used as biomarkers of oxidative stress and inflammation, but the effect of kidney function on these measurements has not been extensively explored.
Baxter-Parker Gregory +6 more
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Neopterin, the Cell-Mediated Immune Response Biomarker, in Inflammatory Periodontal Diseases: A Narrative Review of a More than Fifty Years Old Biomarker [PDF]
Biomedicines, 2023 Neopterin is a biomarker of the activation of cellular immunity. The purpose of this review is to summarise neopterin metabolism, methods of its detection, and its role in inflammation, focusing on periodontal inflammatory diseases.
Ondrej Heneberk +2 more
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Study on potential markers for diagnosis of renal cell carcinoma by serum untargeted metabolomics based on UPLC-MS/MS [PDF]
Frontiers in Physiology, 2022 Objective: Renal cell carcinoma (RCC) is the most common malignancy of the kidney. However, there is no reliable biomarker with high sensitivity and specificity for diagnosis and differential diagnosis. This study aims to analyze serum metabolite profile
Jun Wang +7 more
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Inhibition of haemolysis by the macrophage synthesized antioxidant, 7,8-dihydroneopterin [PDF]
Redox Report, 2000 AbstractNeopterin and the reduced form, 7,8-dihydroneopterin (78NP) are pteridines released from macrophages when stimulated with interferon-γ (IFN-γ) in vivo.1,2 The role of 78NP in inflammatory response is unknown, though neopterin has been used clinically as a marker of immune cell activation due to its very fluorescent nature.
S. Gieseg, G. Maghzal, Dylan M Glubb
semanticscholar +3 more sources
The antioxidants neopterin/7,8‐dihydroneopterin: Novel biomarker and muscle protectant in Duchenne muscular dystrophy [PDF]
Experimental Physiology, 2018 In this issue of Experimental Physiology, Lindsay and colleagues (2018) have shown that accumulation of inflammatory cells in patients with Duchenne muscular dystrophy (DMD) results in an increase in the immune cell-synthesized antioxidants neopterin and
P. Houweling
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