Results 11 to 20 of about 37,816 (179)

Crystal structure of 7,8-dihydroneopterin triphosphate epimerase. [PDF]

Structure, 1999
Dihydroneopterin triphosphate (H2NTP) is the central substrate in the biosynthesis of folate and tetrahydrobiopterin. Folate serves as a cofactor in amino acid and purine biosynthesis and tetrahydrobiopterin is used as a cofactor in amino acid hydroxylation and nitric oxide synthesis.
T. Ploom, C. Haussmann, P. Hof, S. Steinbacher, A. Bacher, J. Richardson, R. Huber   +6 more
semanticscholar   +3 more sources

8-Mercaptoguanine-based inhibitors of Mycobacterium tuberculosis dihydroneopterin aldolase: synthesis, in vitro inhibition and docking studies [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and glycolaldehyde (GA) in the folate pathway.
Alexia de Matos Czeczot, Candida Deves Roth, Rodrigo Gay Ducati, Kenia Pissinate, Raoní Scheibler Rambo, Luís Fernando Saraiva Macedo Timmers, Bruno Lopes Abbadi, Fernanda Souza Macchi, Víctor Zajaczkowski Pestana, Luiz Augusto Basso, Pablo Machado, Cristiano Valim Bizarro   +11 more
doaj   +2 more sources

Epithelial Cell Line Derived from Endometriotic Lesion Mimics Macrophage Nervous Mechanism of Pain Generation on Proteome and Metabolome Levels [PDF]

Biomolecules, 2021
Endometriosis is a benign disease affecting one in ten women of reproductive age worldwide. Although the pain level is not correlated to the extent of the disease, it is still one of the cardinal symptoms strongly affecting the patients’ quality of life.
Benjamin Neuditschko, Marlene Leibetseder, Julia Brunmair, Gerhard Hagn, Lukas Skos, Marlene C. Gerner, Samuel M. Meier-Menches, Iveta Yotova, Christopher Gerner   +8 more
doaj   +2 more sources

Neopterin and 7,8‐dihydroneopterin induce apoptosis in the rat alveolar epithelial cell line L2 [PDF]

FEBS Letters, 1996
The neopterin derivatives, neopterin and 7,8‐dihydroneopterin, modulate the cellular oxidant‐antioxidant balance as well as the expression of the inducible nitric oxide synthase (iNOS) gene. Since apoptosis can be induced by reactive oxygen intermediates and nitric oxide (NO) we investigated whether these neopterin derivatives induce apoptotic cell ...
W. Schobersberger, G. Hoffmann, P. Hobisch‐Hagen, G. Böck, H. Völkl, G. Baier‐Bitterlich, B. Wirleitner, H. Wachter, D. Fuchs   +8 more
semanticscholar   +3 more sources

Inhibition of protein oxidation by the macrophage-synthesised antioxidant 7,8-dihydroneopterin

Redox Report, 2001
Protein is the pivotal component involved in most cellular activities. As the most abundant cellular molecule, it is the most likely target of any reactive oxygen species (ROS).1 Often considered to be a passive target during free radical exposure, there is now considerable evidence showing ROS damage to proteins leads to the formation of reactive ...
S. Duggan, C. Rait, J. Gebicki, S. Gieseg   +3 more
semanticscholar   +3 more sources

The Structures of the Reoxidation Products of 7,8-Dihydroneopterin [PDF]

Bulletin of the Chemical Society of Japan, 1973
Abstract On the reduction of d-erythro-neopterin with sodium dithionite, after which it was let stand in neutral pH, three colorless compounds, I, II, and III, and two yellow compounds, I and II, were obtained. On the reduction of d-erythro-neopterin with Fe dust in 25% acetic acid, after which it was let stand at a neutral pH, two ...
K. Sugiura, M. Goto
semanticscholar   +2 more sources

Integrated metabolome and transcriptome analysis reveals key genes and pathways associated with egg yolk percentage in chicken [PDF]

Poultry Science
Yolk percentage is a critical index in the egg product industry, reflecting both nutritional value and economic benefits. To elucidate the underlying mechanisms that contribute to variations in egg yolk percentage, we performed integrated transcriptome ...
Wen Li, Yuxing Luo, Shoujia Zhu, Mengyuan Wang, Xuli Zhao, Zhonghua Ning   +5 more
doaj   +2 more sources

Inhibition of THP-1 cell-mediated low-density lipoprotein oxidation by the macrophage-synthesised pterin, 7,8-dihydroneopterin [PDF]

Redox Report, 2003
Human macrophages release the pterin, 7,8-dihydroneopterin when exposed to the immune stimulant gamma-interferon (IFN-gamma). Previous in vitro studies have shown 7,8-dihydroneopterin is a potent antioxidant, which inhibits copper- and peroxyl-radical mediated low-density lipoprotein (LDL) oxidation.
S. Gieseg, S. Cato
semanticscholar   +3 more sources

Effect of neopterin and 7,8‐dihydroneopterin on tumor necrosis factor‐α induced programmed cell death

FEBS Letters, 1995
Tumor necrosis factor‐α and the formation of reactive oxygen intermediates are central mediators of apoptosis. Recent data indicated a role of neopterin and 7,8‐dihydroneopterin in oxygen radical mediated processes. We have therefore investigated the effect of neopterin‐derivatives on TNFα induced apoptosis of the monocyte‐like cell line U937.
G. Baier‐Bitterlich, D. Fuchs, C. Murr, Gilbert Reibnegger, G. Werner-Felmayer, R. Sgonc, G. Böck, Dierich Mp, H. Wachter   +8 more
semanticscholar   +3 more sources

Reduction of Ferric Iron by 7,8-Dihydroneopterin

Pteridines, 1990
Hausen A., Fuchs D., Fuchs D., Reibnegger G., Werner E. R., Werner-Felmayer G., Wachter H.   +6 more
doaj   +2 more sources