Inhibition of haemolysis by the macrophage synthesized antioxidant, 7,8-dihydroneopterin [PDF]
Redox Report, 2000 AbstractNeopterin and the reduced form, 7,8-dihydroneopterin (78NP) are pteridines released from macrophages when stimulated with interferon-γ (IFN-γ) in vivo.1,2 The role of 78NP in inflammatory response is unknown, though neopterin has been used clinically as a marker of immune cell activation due to its very fluorescent nature.
Steven P. Gieseg +2 more
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8-Mercaptoguanine-based inhibitors of Mycobacterium tuberculosis dihydroneopterin aldolase: synthesis, in vitro inhibition and docking studies [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and glycolaldehyde (GA) in the folate pathway.
Alexia de Matos Czeczot +11 more
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The antioxidants neopterin/7,8‐dihydroneopterin: Novel biomarker and muscle protectant in Duchenne muscular dystrophy [PDF]
Experimental Physiology, 2018 In this issue of Experimental Physiology, Lindsay and colleagues (2018) have shown that accumulation of inflammatory cells in patients with Duchenne muscular dystrophy (DMD) results in an increase in the immune cell-synthesized antioxidants neopterin and
P. Houweling
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Formation, Transport and Detection of 7,8-Dihydroneopterin [PDF]
, 2013 Atherosclerosis is a chronic inflammatory disease leading to plaque buildup in the major arteries. The plaques consist of cholesterol, calcium, inflammatory cells, extracellular matrix and fibrous material. Under inflammatory conditions IFN-• stimulation of human monocytes and macrophages generates reduced pteridine, 7,8-dihydroneopterin (78NP) which ...
Janmale, Tejraj Vijaykumar
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Inhibition of protein oxidation by the macrophage-synthesised antioxidant 7,8-dihydroneopterin [PDF]
Redox Report, 2001 Protein is the pivotal component involved in most cellular activities. As the most abundant cellular molecule, it is the most likely target of any reactive oxygen species (ROS).1 Often considered to be a passive target during free radical exposure, there is now considerable evidence showing ROS damage to proteins leads to the formation of reactive ...
Christopher Rait +3 more
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Neopterin and 7,8‐dihydroneopterin induce apoptosis in the rat alveolar epithelial cell line L2 [PDF]
FEBS Letters, 1996 The neopterin derivatives, neopterin and 7,8‐dihydroneopterin, modulate the cellular oxidant‐antioxidant balance as well as the expression of the inducible nitric oxide synthase (iNOS) gene. Since apoptosis can be induced by reactive oxygen intermediates and nitric oxide (NO) we investigated whether these neopterin derivatives induce apoptotic cell ...
Harald Völkl +8 more
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Effect of 7,8 -Dihydroneopterin, Biopterin and Isoxanthopterin on Cholesterol and Phospholipid Content and Phospholipid Biosynthesis in Vitro [PDF]
Pteridines, 1996 Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate (Krebs-Ringer-phosphate buffer, pH=7.4, containing 0.3% albumin, fatty acid mixture and glycerol). The addition of 7,8-dihydroneopterin and
Rudzite Vera +4 more
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Epithelial Cell Line Derived from Endometriotic Lesion Mimics Macrophage Nervous Mechanism of Pain Generation on Proteome and Metabolome Levels [PDF]
Biomolecules, 2021 Endometriosis is a benign disease affecting one in ten women of reproductive age worldwide. Although the pain level is not correlated to the extent of the disease, it is still one of the cardinal symptoms strongly affecting the patients’ quality of life.
Benjamin Neuditschko +8 more
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The radical impact of oxygen on prokaryotic evolution-enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third. [PDF]
FEBS LettTraditional views of oxygen's role in evolution focus on improved energy yield in heterotrophic pathways. Before respiratory terminal oxidases arose, however, oxygen potently inhibited anaerobic growth, often by degrading FeS clusters. Several pathways for essential cofactors include enzymes with FeS clusters, selecting for alternative, oxygen‐tolerant
Mrnjavac N +12 more
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Integrated metabolome and transcriptome analysis reveals key genes and pathways associated with egg yolk percentage in chicken [PDF]
Poultry ScienceYolk percentage is a critical index in the egg product industry, reflecting both nutritional value and economic benefits. To elucidate the underlying mechanisms that contribute to variations in egg yolk percentage, we performed integrated transcriptome ...
Wen Li +5 more
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