Results 21 to 30 of about 37,816 (179)

7,8-Dihydroneopterin induces apoptosis of Jurkat T-lymphocytes via a Bcl-2-sensitive pathway.

European Journal of Cell Biology, 2002
Activated cell-mediated immunity is known to be accompanied by elevated concentrations of 7,8-dihydroneopterin which in high concentrations was found to interfere with the oxidant-antioxidant balance. In this study we investigated whether 7,8-dihydroneopterin mediates apoptosis of Jurkat T-lymphocytes via a CrmA- or Bcl-2-sensitive pathway.
C. Enzinger, B. Wirleitner, C. Lutz, G. Böck, Bettina Tomaselli, G. Baier, D. Fuchs, G. Baier‐Bitterlich   +7 more
semanticscholar   +3 more sources

Identification and characterization of new structural scaffolds modulating the activity of Mycobacterium tuberculosis dihydroneopterin aldolase (FolB) in vitro [PDF]

Frontiers in Tropical Diseases
IntroductionAntifolates were among the first broad-spectrum compounds used as antimycobacterial agents and can still be of use when no other therapeutic options are available.
Virginia Carla de Almeida Falcão, Alexia de Matos Czeczot, Alexia de Matos Czeczot, Mohammad Maqusood Alam, Kyu-Ho Paul Park, Jinyeong Heo, Minjeong Woo, Ana Micaela Camini, Luis Fernando Saraiva Macedo Timmers, Luis Fernando Saraiva Macedo Timmers, Luis Fernando Saraiva Macedo Timmers, David Shum, Marcia Alberton Perelló, Luiz Augusto Basso, Luiz Augusto Basso, Luiz Augusto Basso, Pablo Machado, Pablo Machado, Pablo Machado, Cristiano Valim Bizarro, Cristiano Valim Bizarro, Vincent Delorme   +21 more
doaj   +3 more sources

Role of neopterin and 7,8-dihydroneopterin in human immunodeficiency virus infection: marker for disease progression and pathogenic link.

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 1996
Human immunodeficiency virus (HIV) infection is associated with increased concentrations of neopterin derivatives, released in large quantities by human macrophages on stimulation with interferon-gamma (INF-gamma). Neopterin concentrations thus inversely correlate with absolute CD4+ T-cell numbers and strongly predict progression of disease from ...
G. Baier‐Bitterlich, H. Wachter, D. Fuchs   +2 more
semanticscholar   +3 more sources

Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild. [PDF]

Am J Primatol
Neopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Behringer V, Deimel C.
europepmc   +2 more sources

Mutationen im PTS-Gen und mögliche Auswirkungen auf Funktion und Struktur der 6-Pyruvoyl-Tetrahydropterin-Synthase [PDF]

, 2002
Background: Research on Juvenile Idiopathic Arthritis (JIA) should support patients, caregivers/parents (carers) and clinicians to make important decisions in the consulting room and eventually to improve the lives of patients with JIA.
Preuße, Friedrich-Alexander, Prof. Dr. O. Bandmann   +1 more
core   +12 more sources

Mass spectrometry‐based “omics” technologies for the study of gestational diabetes and the discovery of new biomarkers

Mass Spectrometry Reviews, Volume 42, Issue 4, Page 1424-1461, July/August 2023., 2023
Abstract Gestational diabetes (GDM) is one of the most common complications occurring during pregnancy. Diagnosis is performed by oral glucose tolerance test, but harmonized testing methods and thresholds are still lacking worldwide. Short‐term and long‐term effects include obesity, type 2 diabetes, and increased risk of cardiovascular disease.
Marco Roverso, Raghav Dogra, Silvia Visentin, Silvia Pettenuzzo, Luca Cappellin, Paolo Pastore, Sara Bogialli   +6 more
wiley   +1 more source

The Genetic Landscape of Complex Childhood‐Onset Hyperkinetic Movement Disorders

Movement Disorders, Volume 37, Issue 11, Page 2197-2209, November 2022., 2022
ABSTRACT Background and Objective The objective of this study was to better delineate the genetic landscape and key clinical characteristics of complex, early‐onset, monogenic hyperkinetic movement disorders. Methods Patients were recruited from 14 international centers.
Belén Pérez‐Dueñas, Kathleen Gorman, Anna Marcé‐Grau, Juan D. Ortigoza‐Escobar, Alfons Macaya, Federica R. Danti, Katy Barwick, Apostolos Papandreou, Joanne Ng, Esther Meyer, Shekeeb S. Mohammad, Martin Smith, Francesco Muntoni, Pinki Munot, Johanna Uusimaa, Päivi Vieira, Eammon Sheridan, Renzo Guerrini, Jan Cobben, Sanem Yilmaz, Elisa De Grandis, Russell C. Dale, Roser Pons, Kathryn J. Peall, Vincenzo Leuzzi, Manju A. Kurian   +25 more
wiley   +1 more source

A Shared Prebiotic Formation of Neopterins and Guanine Nucleosides from Pyrimidine Bases

Chemistry – A European Journal, Volume 28, Issue 39, July 11, 2022., 2022
The plausible prebiotic availability of 6‐aminopyrimidines makes the formation of purine nucleosides by Traube reaction an interesting pathway to explore. However, the formation of a pterin ring is the preferred outcome relative to purine nucleoside synthesis, which requires a high sugar excess to be significant.
César Menor‐Salván, Bradley T. Burcar, Marcos Bouza, David M. Fialho, Facundo M. Fernández, Nicholas V. Hud   +5 more
wiley   +1 more source

Cerebrospinal fluid metabolomics: detection of neuroinflammation in human central nervous system disease

Clinical &Translational Immunology, Volume 10, Issue 8, 2021., 2021
In this review, we summarise the current human evidence of the use of cerebrospinal fluid metabolomics to detect neuroinflammation in acute and chronic neurological and psychiatric diseases. The review highlights the potential utility of metabolites involved in the tryptophan–kynurenine and nitric oxide pathway and neopterin as biomarkers for ...
Jingya Yan, Unnikrishnan Kuzhiumparambil, Sushil Bandodkar, Russell C Dale, Shanlin Fu   +4 more
wiley   +1 more source

Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing?

Antioxidants, 2018
Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. However, the analysis of neopterin alone neglects the cellular reactions that generate it in response to ...
Steven P. Gieseg, Gregory Baxter-Parker, Angus Lindsay   +2 more
doaj   +1 more source