Results 21 to 30 of about 37,102 (171)

Effect of neopterin and 7,8‐dihydroneopterin on tumor necrosis factor‐α induced programmed cell death

FEBS Letters, 1995
Tumor necrosis factor‐α and the formation of reactive oxygen intermediates are central mediators of apoptosis. Recent data indicated a role of neopterin and 7,8‐dihydroneopterin in oxygen radical mediated processes. We have therefore investigated the effect of neopterin‐derivatives on TNFα induced apoptosis of the monocyte‐like cell line U937.
Gabriele Baier-Bitterlich, Günther Böck, Christian Murr, Roswitha Sgonc, H. Wachter, M. P. Dierich, Gilbert Reibnegger, Dietmar Fuchs, Gabriele Werner-Felmayer   +8 more
openaire   +4 more sources

Inhibition of THP-1 cell-mediated low-density lipoprotein oxidation by the macrophage-synthesised pterin, 7,8-dihydroneopterin [PDF]

Redox Report, 2003
Human macrophages release the pterin, 7,8-dihydroneopterin when exposed to the immune stimulant gamma-interferon (IFN-gamma). Previous in vitro studies have shown 7,8-dihydroneopterin is a potent antioxidant, which inhibits copper- and peroxyl-radical mediated low-density lipoprotein (LDL) oxidation.
Steven P. Gieseg, Sara Cato
openaire   +4 more sources

Influence of 7,8 Dihydroneopterin and Hyperoxia on Neurite Growth and Tyrosine Hydroxylase Activity of PC 12 Cells

Pteridines, 2002
The influence of dihydroneopterin on tyrosine hydroxylase activity in PC 12 cells was investigated under normoxic and hyperoxic conditions, and with or without iron ions in the incubation medium.
Vrecko Karoline, Reibnegger Gilbert
doaj   +3 more sources

Protein and thiol oxidation in cells exposed to peroxyl radicals is inhibited by the macrophage synthesised pterin 7,8-dihydroneopterin

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2002
Monocyte cells are exposed to a range of reactive oxygen species (ROS) when they are recruited to a site of inflammation. In this study, we have examined the damage caused to the monocyte-like cell line U937 by peroxyl radicals and characterised the protective effect of the macrophage synthesised compound 7,8-dihydroneopterin. Exposure of U937 cells to
Christopher Rait, Aaron A. Platt, Steven P. Gieseg, Sean Duggan   +3 more
openaire   +4 more sources

Identification and characterization of new structural scaffolds modulating the activity of Mycobacterium tuberculosis dihydroneopterin aldolase (FolB) in vitro [PDF]

Frontiers in Tropical Diseases
IntroductionAntifolates were among the first broad-spectrum compounds used as antimycobacterial agents and can still be of use when no other therapeutic options are available.
Virginia Carla de Almeida Falcão, Alexia de Matos Czeczot, Alexia de Matos Czeczot, Mohammad Maqusood Alam, Kyu-Ho Paul Park, Jinyeong Heo, Minjeong Woo, Ana Micaela Camini, Luis Fernando Saraiva Macedo Timmers, Luis Fernando Saraiva Macedo Timmers, Luis Fernando Saraiva Macedo Timmers, David Shum, Marcia Alberton Perelló, Luiz Augusto Basso, Luiz Augusto Basso, Luiz Augusto Basso, Pablo Machado, Pablo Machado, Pablo Machado, Cristiano Valim Bizarro, Cristiano Valim Bizarro, Vincent Delorme   +21 more
doaj   +3 more sources

OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2005
The atherosclerotic plaque is an inflammatory site where macrophage cells are exposed to cytotoxic oxidised low density lipoprotein (oxLDL). Interferon-gamma released from T-cells results in macrophage synthesis of 7,8-dihydroneopterin which has antioxidant and cytoprotective activity. Using the human derived monocyte-like U937 and THP-1 cell lines, we
Mark B. Hampton, Sarah K. Baird, Steven P. Gieseg, Linzi Reid   +3 more
openaire   +4 more sources

Reduction of Ferric Iron by 7,8-Dihydroneopterin

Pteridines, 1990
Hausen A., Fuchs D., Fuchs D., Reibnegger G., Werner E. R., Werner-Felmayer G., Wachter H.   +6 more
doaj   +3 more sources

Macrophage mediated protein hydroperoxide formation and lipid oxidation in low density lipoprotein are inhibited by the inflammation marker 7,8-dihydroneopterin

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2008
The formation of oxidised low density lipoprotein (LDL) within the atherosclerotic plaque appears to be a factor in the development of advanced atherosclerotic plaques. LDL oxidation is dependent on the balance of oxidants and antioxidants within the intima. In addition to producing various oxidants, human macrophages release 7,8-dihydroneopterin which
Elizabeth M. Crone, Elizabeth A. Flavall, Justin A. Roake, Carole A. Firth, Steven P. Gieseg   +4 more
openaire   +4 more sources

7,8-Dihydroneopterin induces apoptosis of Jurkat T-lymphocytes via a Bcl-2-sensitive pathway

European Journal of Cell Biology, 2002
Activated cell-mediated immunity is known to be accompanied by elevated concentrations of 7,8-dihydroneopterin which in high concentrations was found to interfere with the oxidant-antioxidant balance. In this study we investigated whether 7,8-dihydroneopterin mediates apoptosis of Jurkat T-lymphocytes via a CrmA- or Bcl-2-sensitive pathway.
Gabriele Baier-Bitterlich, Günther Böck, Dietmar Fuchs, Christiane Enzinger, Barbara Wirleitner, Christina Lutz, Bettina Tomaselli, Gottfried Baier   +7 more
openaire   +4 more sources

Mass spectrometry‐based “omics” technologies for the study of gestational diabetes and the discovery of new biomarkers

Mass Spectrometry Reviews, Volume 42, Issue 4, Page 1424-1461, July/August 2023., 2023
Abstract Gestational diabetes (GDM) is one of the most common complications occurring during pregnancy. Diagnosis is performed by oral glucose tolerance test, but harmonized testing methods and thresholds are still lacking worldwide. Short‐term and long‐term effects include obesity, type 2 diabetes, and increased risk of cardiovascular disease.
Marco Roverso, Raghav Dogra, Silvia Visentin, Silvia Pettenuzzo, Luca Cappellin, Paolo Pastore, Sara Bogialli   +6 more
wiley   +1 more source