Results 31 to 40 of about 37,102 (171)

Mutationen im PTS-Gen und mögliche Auswirkungen auf Funktion und Struktur der 6-Pyruvoyl-Tetrahydropterin-Synthase [PDF]

, 2002
Background: Research on Juvenile Idiopathic Arthritis (JIA) should support patients, caregivers/parents (carers) and clinicians to make important decisions in the consulting room and eventually to improve the lives of patients with JIA.
Preuße, Friedrich-Alexander, Prof. Dr. O. Bandmann   +1 more
core   +12 more sources

The Genetic Landscape of Complex Childhood‐Onset Hyperkinetic Movement Disorders

Movement Disorders, Volume 37, Issue 11, Page 2197-2209, November 2022., 2022
ABSTRACT Background and Objective The objective of this study was to better delineate the genetic landscape and key clinical characteristics of complex, early‐onset, monogenic hyperkinetic movement disorders. Methods Patients were recruited from 14 international centers.
Belén Pérez‐Dueñas, Kathleen Gorman, Anna Marcé‐Grau, Juan D. Ortigoza‐Escobar, Alfons Macaya, Federica R. Danti, Katy Barwick, Apostolos Papandreou, Joanne Ng, Esther Meyer, Shekeeb S. Mohammad, Martin Smith, Francesco Muntoni, Pinki Munot, Johanna Uusimaa, Päivi Vieira, Eammon Sheridan, Renzo Guerrini, Jan Cobben, Sanem Yilmaz, Elisa De Grandis, Russell C. Dale, Roser Pons, Kathryn J. Peall, Vincenzo Leuzzi, Manju A. Kurian   +25 more
wiley   +1 more source

A Shared Prebiotic Formation of Neopterins and Guanine Nucleosides from Pyrimidine Bases

Chemistry – A European Journal, Volume 28, Issue 39, July 11, 2022., 2022
The plausible prebiotic availability of 6‐aminopyrimidines makes the formation of purine nucleosides by Traube reaction an interesting pathway to explore. However, the formation of a pterin ring is the preferred outcome relative to purine nucleoside synthesis, which requires a high sugar excess to be significant.
César Menor‐Salván, Bradley T. Burcar, Marcos Bouza, David M. Fialho, Facundo M. Fernández, Nicholas V. Hud   +5 more
wiley   +1 more source

Cerebrospinal fluid metabolomics: detection of neuroinflammation in human central nervous system disease

Clinical &Translational Immunology, Volume 10, Issue 8, 2021., 2021
In this review, we summarise the current human evidence of the use of cerebrospinal fluid metabolomics to detect neuroinflammation in acute and chronic neurological and psychiatric diseases. The review highlights the potential utility of metabolites involved in the tryptophan–kynurenine and nitric oxide pathway and neopterin as biomarkers for ...
Jingya Yan, Unnikrishnan Kuzhiumparambil, Sushil Bandodkar, Russell C Dale, Shanlin Fu   +4 more
wiley   +1 more source

The Structures of the Reoxidation Products of 7,8-Dihydroneopterin [PDF]

Bulletin of the Chemical Society of Japan, 1973
Abstract On the reduction of d-erythro-neopterin with sodium dithionite, after which it was let stand in neutral pH, three colorless compounds, I, II, and III, and two yellow compounds, I and II, were obtained. On the reduction of d-erythro-neopterin with Fe dust in 25% acetic acid, after which it was let stand at a neutral pH, two ...
Katsura Sugiura, Miki Goto
openaire   +2 more sources

Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing?

Antioxidants, 2018
Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. However, the analysis of neopterin alone neglects the cellular reactions that generate it in response to ...
Steven P. Gieseg, Gregory Baxter-Parker, Angus Lindsay   +2 more
doaj   +1 more source

One‐carbon metabolism, folate, zinc and translation

Microbial Biotechnology, Volume 13, Issue 4, Page 899-925, July 2020., 2020
The translation machinery integrates the metabolism of carbon, nitrogen, sulfur and phospahte via a tight association between one‐carbon metabolism and the zinc divalent ion. Summary The translation process, central to life, is tightly connected to the one‐carbon (1‐C) metabolism via a plethora of macromolecule modifications and specific effectors ...
Antoine Danchin, Agnieszka Sekowska, Conghui You   +2 more
wiley   +1 more source

Evaluation of the pharmacological effects and exploration of the mechanism of traditional Chinese medicine preparation Ciwujia tablets in treating insomnia based on ethology, energy metabolism, and urine metabolomic approaches

Frontiers in Pharmacology, 2022
Ciwujia Tablets (CWT) are produced by concentrating and drying the extract solution of the dried rhizome of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim [Araliaceae; E. senticosus radix et rhizoma].
Hongda Liu, Le Yang, Chunlei Wan, Zhineng Li, Guangli Yan, Ying Han, Hui Sun, Xijun Wang, Xijun Wang, Xijun Wang   +9 more
doaj   +1 more source

Untargeted Metabolomic Profiling Using UHPLC‐QTOF/MS Reveals Metabolic Alterations Associated with Autism

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Autism spectrum disorder (ASD) is a clinical spectrum of neurodevelopment disorder characterized by deficits in social communication and social interaction along with repetitive/stereotyped behaviors. The current diagnosis for autism relies entirely on clinical evaluation and has many limitations.
Yujie Liang, Xiaoyin Ke, Zhou Xiao, Ying Zhang, Yangxia Chen, Yingyuan Li, Zhonglei Wang, Ling Lin, Paul Yao, Jianping Lu, Kazuhisa Nishizawa   +10 more
wiley   +1 more source

7,8-Dihydroneopterin Upregulates Interferon-γ Promoterin T cells

Immunobiology, 1996
Activated cell-mediated immunity is accompanied by elevated concentrations of interferon-gamma leading to the secretion of neopterin-derivatives which are known as sensitive immune activation markers in clinical laboratory diagnosis. Recent data imply a potential role of neopterin-derivatives in oxygen-free radical-mediated processes and a direct ...
Dietmar Fuchs, Helmut Wachter, Gabriele Baier-Bitterlich   +2 more
openaire   +2 more sources