Results 31 to 40 of about 37,816 (179)

An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae [PDF]

, 2017
Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded for high mortalities worldwide.
Azevedo, Vasco A.C., Barh, Debmalya, Baumbach, Jan, Benevides, Leandro de Jesus, Costa, Daniela Arruda, Ghosh, Preetam, Hassan, Syed Shah, Jamal, Syed Babar, Röttger, Richard, Silva, Artur, Tiwari, Sandeep, Turjanski, Adrián G., Ullah, Asad, Viana, Marcus V.   +13 more
core   +9 more sources

7,8-Dihydroneopterin Upregulates Interferon-γ Promoterin T cells

Immunobiology, 1996
Activated cell-mediated immunity is accompanied by elevated concentrations of interferon-gamma leading to the secretion of neopterin-derivatives which are known as sensitive immune activation markers in clinical laboratory diagnosis. Recent data imply a potential role of neopterin-derivatives in oxygen-free radical-mediated processes and a direct ...
G, Baier-Bitterlich, D, Fuchs, H, Wachter   +2 more
openaire   +2 more sources

Effect of 7,8 -Dihydroneopterin, Biopterin and Isoxanthopterin on Cholesterol and Phospholipid Content and Phospholipid Biosynthesis in Vitro

Pteridines, 1996
Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate (Krebs-Ringer-phosphate buffer, pH=7.4, containing 0.3% albumin, fatty acid mixture and glycerol). The addition of 7,8-dihydroneopterin and
Rudzite Vera, Jurika Edite, Baier-Bitterlich Gabriele, Wachterl Helmut, Fuchs Dietmar   +4 more
doaj   +1 more source

Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I [PDF]

, 2014
BACKGROUND: Antifolates are currently in clinical use for malaria preventive therapy and treatment. The drugs kill the parasites by targeting the enzymes in the de novo folate pathway.
Krittikorn Kümpornsin, Namfon Kotanan, Peera Jaru-ampornpan, Piyaporn Jirawatcharadech, Pornpimol Chobson, Thanat Chookajorn, Theerarat Kochakarn, Yongyuth Yuthavong   +7 more
core   +2 more sources

Evaluation of the pharmacological effects and exploration of the mechanism of traditional Chinese medicine preparation Ciwujia tablets in treating insomnia based on ethology, energy metabolism, and urine metabolomic approaches

Frontiers in Pharmacology, 2022
Ciwujia Tablets (CWT) are produced by concentrating and drying the extract solution of the dried rhizome of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim [Araliaceae; E. senticosus radix et rhizoma].
Hongda Liu, Le Yang, Chunlei Wan, Zhineng Li, Guangli Yan, Ying Han, Hui Sun, Xijun Wang, Xijun Wang, Xijun Wang   +9 more
doaj   +1 more source

One‐carbon metabolism, folate, zinc and translation

Microbial Biotechnology, Volume 13, Issue 4, Page 899-925, July 2020., 2020
The translation machinery integrates the metabolism of carbon, nitrogen, sulfur and phospahte via a tight association between one‐carbon metabolism and the zinc divalent ion. Summary The translation process, central to life, is tightly connected to the one‐carbon (1‐C) metabolism via a plethora of macromolecule modifications and specific effectors ...
Antoine Danchin, Agnieszka Sekowska, Conghui You   +2 more
wiley   +1 more source

Untargeted Metabolomic Profiling Using UHPLC‐QTOF/MS Reveals Metabolic Alterations Associated with Autism

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Autism spectrum disorder (ASD) is a clinical spectrum of neurodevelopment disorder characterized by deficits in social communication and social interaction along with repetitive/stereotyped behaviors. The current diagnosis for autism relies entirely on clinical evaluation and has many limitations.
Yujie Liang, Xiaoyin Ke, Zhou Xiao, Ying Zhang, Yangxia Chen, Yingyuan Li, Zhonglei Wang, Ling Lin, Paul Yao, Jianping Lu, Kazuhisa Nishizawa   +10 more
wiley   +1 more source

Effect of Neopterin Derivatives on Mitochondrial Dehydrogenase Activity in Ovarian Carcinoma Cell Lines in Vitro

Pteridines, 2006
In a recent study we could show that neopterin inhibits nitric oxide-induced apoptosis in ovarian carcinoma cells. This may provide an explanation for the correlation between increased levels of neopterin derivatives and the unfavorable prognosis in ...
Rieder Josef, Marth Christian, Hoffmann' Georg   +2 more
doaj   +1 more source

Functional Promiscuity of the COG0720 Family [PDF]

, 2011
The biosynthesis of GTP derived metabolites such as tetrahydrofolate (THF), biopterin (BH4), and the modified tRNA nucleosides queuosine (Q) and archaeosine (G+) relies on several enzymes of the Tunnel-fold superfamily. A subset of these proteins include
Bailly, Marc, Bonnett, Shilah, de Crécy-Lagard, Valérie, El Yacoubi, Basma, Grochowski, Laura L., Haas-Blaby, Crysten, Iwata-Reuyl, Dirk, Phillips, Gabriela, White, Robert H., Xu, Huimin   +9 more
core   +2 more sources

Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler

International Journal of Genomics, Volume 2020, Issue 1, 2020., 2020
The antler regeneration has been well studied for the past two decades and adopted in the regenerative medicine model for studying on developmental biology. Despite our growing knowledge of functional molecules regulating antler regeneration, we still do not know whether antler from different deer species possess the exact same mechanism or not.
Hang Su, Chonghui Yang, Chenrong Jin, He Zhang, Chengcheng Yin, Yang Yang, Haoyuan Chen, Li Jing, Bin Qi, Daqing Zhao, Xueyuan Bai, Li Liu, Atsushi Kurabayashi   +12 more
wiley   +1 more source