Results 41 to 50 of about 37,102 (171)

Comparative Metabolomics Study Revealed Difference in Central Carbon Metabolism between Sika Deer and Red Deer Antler

International Journal of Genomics, Volume 2020, Issue 1, 2020., 2020
The antler regeneration has been well studied for the past two decades and adopted in the regenerative medicine model for studying on developmental biology. Despite our growing knowledge of functional molecules regulating antler regeneration, we still do not know whether antler from different deer species possess the exact same mechanism or not.
Hang Su, Chonghui Yang, Chenrong Jin, He Zhang, Chengcheng Yin, Yang Yang, Haoyuan Chen, Li Jing, Bin Qi, Daqing Zhao, Xueyuan Bai, Li Liu, Atsushi Kurabayashi   +12 more
wiley   +1 more source

Effect of Neopterin Derivatives on Mitochondrial Dehydrogenase Activity in Ovarian Carcinoma Cell Lines in Vitro

Pteridines, 2006
In a recent study we could show that neopterin inhibits nitric oxide-induced apoptosis in ovarian carcinoma cells. This may provide an explanation for the correlation between increased levels of neopterin derivatives and the unfavorable prognosis in ...
Rieder Josef, Marth Christian, Hoffmann' Georg   +2 more
doaj   +1 more source

Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I [PDF]

, 2014
BACKGROUND: Antifolates are currently in clinical use for malaria preventive therapy and treatment. The drugs kill the parasites by targeting the enzymes in the de novo folate pathway.
Krittikorn Kümpornsin, Namfon Kotanan, Peera Jaru-ampornpan, Piyaporn Jirawatcharadech, Pornpimol Chobson, Thanat Chookajorn, Theerarat Kochakarn, Yongyuth Yuthavong   +7 more
core   +2 more sources

Pterins as diagnostic markers of mechanical and impact-induced trauma: A systematic review [PDF]

, 2022
We performed a systematic review of the literature to evaluate pterins as biomarkers of mechanical and impact-induced trauma. MEDLINE and Scopus were searched in March 2019.
Baxter-Parker G, Gieseg, Steven, Lindsay A   +2 more
core   +1 more source

Functional Promiscuity of the COG0720 Family [PDF]

, 2011
The biosynthesis of GTP derived metabolites such as tetrahydrofolate (THF), biopterin (BH4), and the modified tRNA nucleosides queuosine (Q) and archaeosine (G+) relies on several enzymes of the Tunnel-fold superfamily. A subset of these proteins include
Bailly, Marc, Bonnett, Shilah, de Crécy-Lagard, Valérie, El Yacoubi, Basma, Grochowski, Laura L., Haas-Blaby, Crysten, Iwata-Reuyl, Dirk, Phillips, Gabriela, White, Robert H., Xu, Huimin   +9 more
core   +2 more sources

Neopterin-induced Suppression of Erythropoietin Production In Vitro

Pteridines, 1995
The production of neopterin increases in several diseases with activation of the ceIlular immune response. As previously shown serum concentrations of neopterin are inversely correlated with blood hemoglobin concentrations in the anemia of hematological ...
Schobersberger W., Jelkmann W., Fandrey J., Frede S., Wachter H., Fuchs D.   +5 more
doaj   +1 more source

Probing the Structural Dynamics of the Plasmodium falciparum Tunneling-Fold Enzyme 6-Pyruvoyl Tetrahydropterin Synthase to Reveal Allosteric Drug Targeting Sites

Frontiers in Molecular Biosciences, 2020
The de novo folate synthesis pathway is a well-established drug target in the treatment of many infectious diseases. Antimalarial antifolate drugs have proven to be effective against malaria, however, rapid drug resistance has emerged on the two primary ...
Afrah Khairallah, Caroline J. Ross, Özlem Tastan Bishop   +2 more
doaj   +1 more source

Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations [PDF]

, 2007
Background Folate synthesis and salvage pathways are relatively well known from classical biochemistry and genetics but they have not been subjected to comparative genomic analysis.
de Crécy-Lagard, Valérie, de la Garza, Rocío Díaz, El Yacoubi, Basma, Hanson, Andrew D, Noiriel, Alexandre   +4 more
core   +3 more sources

The physiological and mononuclear cell activation response to cryotherapy following a mixed martial arts contest: a pilot study

Pteridines, 2015
Cold water immersion is thought to reduce the inflammatory response to injury. Using cultured mononuclear cells and human subjects in a mixed martial arts (MMA) contest, we examined the effect of cryotherapy on 7,8-dihydroneopterin and neopterin ...
Lindsay Angus, Carr Sam, Othman Mohd Izani, Marks Edward, Davies Sian, Petersen Carl, Draper Nick, Gieseg Steven P.   +7 more
doaj   +1 more source

Frailty status in older adults is related to alterations in indoleamine 2,3-dioxygenase 1 and guanosine triphosphate cyclohydrolase I enzymatic pathways [PDF]

, 2017
Original studyXunta de Galicia; ED431B 2016/013Xunta de Galicia; GPC2014/082Xunta de Galicia; IN607C 2016 ...
Fuchs, Dietmar, Gostner, Johanna, Laffon, Blanca, Lorenzo-López, Laura, Marcos Pérez, Diego, Maseda, Ana, Millán-Calenti, José Carlos, Pásaro, Eduardo, Strasser, Barbara, Sánchez-Flores, María, Valdiglesias, Vanessa   +10 more
core   +2 more sources