Results 1 to 10 of about 416 (114)

In silico investigation of mitragynine and 7-hydroxymitragynine metabolism [PDF]

BMC Research Notes, 2019
Objective Mitragynine is the main active compound of Mitragyna speciose (Kratom in Thai). The understanding of mitragynine derivative metabolism in human body is required to develop effective detection techniques in case of drug abuse or establish an ...
Taweetham Limpanuparb, Rattha Noorat, Yuthana Tantirungrotechai   +2 more
doaj   +5 more sources

Inhibitory effects of Kratom constituents, mitragynine and 7-hydroxymitragynine, on 4-methylumbelliferone glucuronidation by human UDP-glucuronosyltransferases [PDF]

Toxicology Reports
As Kratom use increases, concerns about potential herb-drug interactions with liver enzymes, particularly UDP-glucuronosyltransferases (UGTs), have emerged.
Verawan Uchaipichat
doaj   +4 more sources

7‑Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects [PDF]

ACS Central Science, 2019
Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction. Recently, growing use of the plant in the United States and concerns that kratom represents an uncontrolled drug with potential abuse liability, have ...
Andrew C. Kruegel, Rajendra Uprety, Steven G. Grinnell, Cory Langreck, Elizabeth A. Pekarskaya, Valerie Le Rouzic, Michael Ansonoff, Madalee M. Gassaway, John E. Pintar, Gavril W. Pasternak, Jonathan A. Javitch, Susruta Majumdar, Dalibor Sames   +12 more
doaj   +7 more sources

From kratom to 7-hydroxymitragynine: evolution of a natural remedy into a public-health threat [PDF]

Pharmaceutical Biology
Context Kratom (Mitragyna speciosa), native to Southeast Asia, has traditionally been consumed as fresh leaves or teas. Under those conditions, exposure to 7-hydroxymitragynine (7-OH)—a potent μ-opioid receptor agonist—is minimal, as it occurs only at ...
Scott Alsbrook, George Pro, Igor Koturbash   +2 more
doaj   +3 more sources

Human Mitragynine and 7-Hydroxymitragynine Pharmacokinetics after Single and Multiple Daily Doses of Oral Encapsulated Dried Kratom Leaf Powder [PDF]

Molecules
Kratom leaves, consumed by millions worldwide as tea or ground leaf powder, contain multiple alkaloids, with mitragynine being the most abundant and responsible for most effects.
Marilyn A. Huestis, Martin A. Brett, John Bothmer, Ramsey Atallah   +3 more
doaj   +4 more sources

Unveiling 7‑Hydroxymitragynine as the Key Active Metabolite of Mitragynine and the Promise for Creating Novel Pain Relievers [PDF]

ACS Central Science, 2019
A metabolism-dependent mechanism helps to understand mitragynine’s opioid pharmacology and its analgesic activity.
Mariana Spetea, Helmut Schmidhammer
doaj   +4 more sources

Electrical breakdown in liquid-phase processing on an enhancement of 7-hydroxymitragynine conversion from mitragynine in Mitragyna speciose (Kratom) [PDF]

Heliyon
This study investigates the impact of the Electrical Breakdown in Liquid-phase (EBL) process on alkaloid transformation in Mitragyna speciose (Kratom) leaves, focusing on the conversion of mitragynine (MG) to 7-hydroxy mitragynine (7-OH-MG) by using ...
Weerasak Samee, Khanit Matra, Nattawut Lakkham, Beelawan Dongkaew, Passakorn Sumkhum, Wutthichok Sangwang, Wasin Nupangtha, Jiraporn Promping   +7 more
doaj   +4 more sources

Oral Pharmacokinetics in Beagle Dogs of the Mitragynine Metabolite, 7-Hydroxymitragynine. [PDF]

Eur J Drug Metab Pharmacokinet, 2021
7-Hydroxymitragynine (7-HMG) is an oxidative metabolite of mitragynine, the most abundant alkaloid in the leaves of Mitragyna speciosa (otherwise known as kratom). While mitragynine is a weak partial µ-opioid receptor (MOR) agonist, 7-HMG is a potent and full MOR agonist.
Maxwell EA, King TI, Kamble SH, Raju KSR, Berthold EC, León F, Hampson A, McMahon LR, McCurdy CR, Sharma A.   +9 more
europepmc   +3 more sources

Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine. [PDF]

J Med Toxicol, 2016
Kratom (Mitragyna speciosa), a plant native to Southeast Asia, has been used for centuries for its stimulant and opium-like effects. Mitragynine and 7-hydroxymitragynine, exclusive to M. speciosa, are the alkaloids primary responsible for Kratom's biologic and psychoactive profile, and likely contribute to its problematic use.
Lydecker AG, Sharma A, McCurdy CR, Avery BA, Babu KM, Boyer EW.   +5 more
europepmc   +5 more sources

Bayesian inference for integrated pharmacokinetic modelling of mitragynine and 7-hydroxymitragynine [PDF]

ADMET and DMPK
Background and purpose: Mitragynine is an active compound in kratom that is metabolized to the pharmacologically active 7-hydroxymitragynine, requiring an integrated pharmacokinetic approach to maintain plasma concentrations of both within the optimal ...
Dion Notario, Untung Gunawan, Pretty Falena Atmanda Kambira, Erna Wulandari, Eko Adi Prasetyanto   +4 more
doaj   +2 more sources