Results 21 to 30 of about 416 (114)

Case Report: Cannabis and kratom-induced self-amputation of ears and penis [PDF]

Frontiers in Psychiatry
This report describes the case of a 31-year-old male lumberjack with severe self-inflicted injuries, including the amputation of both auricles and the penis, under the influence of cannabinoids, mitragynine, and 7-hydroxymitragynine.
Marek Broul, Marek Broul, Marek Broul, Xenia Rudenko, Adam Bajus, Jiří Král, Dan Mwemena Kyenge, Zdenka Staňková, Jakub Albrecht, Jakub Albrecht   +9 more
doaj   +2 more sources

A review on multi-therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine: Experimental evidence and future perspectives

Kuwait Journal of Science
Mitragyna speciosa (kratom) is a traditional medicinal plant of Southeast Asia, known for its pharmacologically active alkaloids, mitragynine and 7-hydroxymitragynine.
Taslima Begum, Mohd Hafiz Arzmi, Murni Nazira Sarian, Syed Adnan Ali Shah, Syed Najmul Hejaz Azmi, ABM Helal Uddin, Alfi Khatib, Qamar Uddin Ahmed   +7 more
doaj   +2 more sources

Insights into the alteration of vaginal microbiota and metabolites in pregnant woman with preterm delivery: prospective cohort study [PDF]

Frontiers in Cellular and Infection Microbiology
Disruptions in vaginal microbiota and metabolites during pregnancy may be the most important risk factor for preterm delivery, thus the difference in vaginal microbiota and metabolites between women who subsequently delivered at term and who eventually ...
Lihua Wang, Jun Zhang, Mengjun Zhang, Zhimin Xu, Yijing Zheng, Bingqing Lv, Mian Pan   +6 more
doaj   +2 more sources

Discovery of rhynchophylline and mitraphylline in two Thai Mitragyna species and the investigation of their biological activity via opioid gene expression analysis [PDF]

Scientific Reports
Mitragyna speciosa (Ms), M. diversifolia (Md), M. hirsuta (Mh) and M. rotundifolia (Mr) were investigated for phytochemicals by GC-MS and GC-FID, cytotoxicity and genotoxicity testing by MTT and comet assay, and biological activity examination through ...
Runglawan Sudmoon, Tawatchai Tanee, Warin Wonok, Unchaleeporn Ameamsri, Thomas Liehr, Sakda Daduang, Pornnarong Siripiyasing, Arunrat Chaveerach   +7 more
doaj   +2 more sources

Cosmeceutical Potential of Mitragyna speciosa (Kratom): Anti-Adipogenic and Antioxidant Properties of Extracts and Mitragynine [PDF]

Molecules
Kratom (Mitragyna speciosa (Korth.) Havil.) is a medicinal plant containing bioactive alkaloids, notably mitragynine and 7-hydroxymitragynine, which are psychoactive compounds with analgesic and stimulant properties.
Sudthiworarak Kaewchompoo, Prapapan Temkitthawon, Kalyarut Phumlek, Neti Waranuch, Ngamrayu Ngamdokmai, Kornkanok Ingkaninan   +5 more
doaj   +2 more sources

Asymmetric Total Syntheses of Mitragynine, Speciogynine, and 7-Hydroxymitragynine

Chemical and Pharmaceutical Bulletin, 2022
A number of alkaloids found in Mitragyna species belonging to the Rubiaceae family have been shown to have potent biological activity such as analgesic properties. Here, we report the asymmetric total syntheses of mitragynine, speciogynine, and 7-hydroxymitragynine, which are classified as corynantheine-type monoterpenoid indole alkaloids, isolated ...
Jukiya, Sakamoto, Mariko, Kitajima, Hayato, Ishikawa   +2 more
openaire   +2 more sources

Biosynthesis of kratom opioids

New Phytologist, Volume 240, Issue 2, Page 757-769, October 2023., 2023
Summary Mitragynine, an analgesic alkaloid from the plant Mitragyna speciosa (kratom), offers a safer alternative to clinical opioids such as morphine, owing to its more favorable side effect profile. Although kratom has been traditionally used for stimulation and pain management in Southeast Asia, the mitragynine biosynthesis pathway has remained ...
Kyunghee Kim, Mohammadamin Shahsavarani, Jorge Jonathan Oswaldo Garza‐García, Jack Edward Carlisle, Jun Guo, Vincenzo De Luca, Yang Qu   +6 more
wiley   +1 more source

Case Report: Treatment of Kratom Use Disorder With a Classical Tricyclic Antidepressant

Frontiers in Psychiatry, 2021
Kratom or Mitragyna speciosa (Korth.) is an evergreen tree of the coffee family native to South-East Asia and Australasia. It is used by locals recreationally to induce stimulant and sedative effects and medically to soothe pain and opiate withdrawal ...
Alessandro E. Vento, Alessandro E. Vento, Simone de Persis, Sergio De Filippis, Fabrizio Schifano, Flavia Napoletano, John M. Corkery, Georgios D. Kotzalidis, Georgios D. Kotzalidis   +8 more
doaj   +1 more source

Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom

Clinical Pharmacology &Therapeutics, Volume 113, Issue 6, Page 1315-1325, June 2023., 2023
Oral formulations prepared from the leaves of the kratom (Mitragyna speciosa) plant are increasingly used for their opioid‐like effects to self‐manage opioid withdrawal and pain. Calls to US poison centers involving kratom exposures increased >50‐fold from 2011–2017, one‐third of which reported concomitant use of kratom with drugs of abuse.
Rakshit S. Tanna, James T. Nguyen, Deena L. Hadi, Matthew E. Layton, John R. White, Nadja B. Cech, Nicholas H. Oberlies, Allan E. Rettie, Kenneth E. Thummel, Mary F. Paine   +9 more
wiley   +1 more source

Mitragyna Species as Pharmacological Agents: From Abuse to Promising Pharmaceutical Products

Life, 2022
Mitragyna is a genus belonging to the Rubiaceae family and is a plant endemic to Asia and Africa. Traditionally, the plants of this genus were used by local people to treat some diseases from generation to generation.
Islamudin Ahmad, Wisnu Cahyo Prabowo, Muhammad Arifuddin, Jaka Fadraersada, Niken Indriyanti, Herman Herman, Reza Yuridian Purwoko, Firzan Nainu, Anton Rahmadi, Swandari Paramita, Hadi Kuncoro, Nur Mita, Angga Cipta Narsa, Fajar Prasetya, Arsyik Ibrahim, Laode Rijai, Gemini Alam, Abdul Mun’im, Sukanya Dej-adisai   +18 more
doaj   +1 more source