Results 51 to 60 of about 416 (114)

An Alternative Paradigm for the Role of Antimalarial Plants in Africa

The Scientific World Journal, Volume 2012, Issue 1, 2012., 2012
Most investigations into the antimalarial activity of African plants are centered on finding an indigenous equivalent to artemisinin, the compound from which current frontline antimalarial drugs are synthesized. As a consequence, the standard practice in ethnopharmacological research is to use in vitro assays to identify compounds that inhibit ...
Steven Maranz, Yasushi Shigeri
wiley   +1 more source

Metabolomics data of Mitragyna speciosa leaf using LC-ESI-TOF-MS

Data in Brief, 2018
Mitragyna speciosa is a psychoactive plant known as “ketum” in Malaysia and “kratom” in Thailand. This plant is distinctly known to produce two important alkaloids, namely mitragynine (MG) and 7-hydroxymitragynine (7-OH-MG) that can bind to opioid ...
Rubashiny Veeramohan, Kamalrul Azlan Azizan, Wan Mohd Aizat, Hoe-Han Goh, Sharif Mahsufi Mansor, Nur Sabrina Mohd Yusof, Syarul Nataqain Baharum, Chyan Leong Ng   +7 more
doaj   +1 more source

Broad evidence of xylazine in the UK illicit drug market beyond heroin supplies: Triangulating from toxicology, drug‐testing and law enforcement

Addiction, Volume 119, Issue 7, Page 1301-1309, July 2024.
Abstract Background and aims Xylazine is a non‐opioid sedative which has spread rapidly throughout the US illicit drug supply. This study aimed to describe the spread of xylazine throughout the UK illicit drug supply. Methods Xylazine detections in human biological samples were collated from toxicology laboratories operating in the United Kingdom with ...
Caroline S. Copeland, Kathleen Rice, Kirsten L. Rock, Simon Hudson, Peter Streete, Alexander J. Lawson, Lewis Couchman, Adam Holland, Stephen Morley   +8 more
wiley   +1 more source

Effects of Nutrient Fertility on Growth and Alkaloidal Content in Mitragyna speciosa (Kratom)

Frontiers in Plant Science, 2020
Leaves harvested from the Southeast Asian tree Mitragyna speciosa (kratom) have a history of use as a traditional ethnobotanical source of medicine to combat fatigue, improve work productivity, and to reduce opioid-related withdrawal symptoms.
Mengzi Zhang, Abhisheak Sharma, Francisco León, Bonnie Avery, Bonnie Avery, Roger Kjelgren, Christopher R. McCurdy, Christopher R. McCurdy, Brian J. Pearson   +8 more
doaj   +1 more source

Mitragynine and 7-Hydroxymitragynine: Bidirectional Effects on Breathing in Rats

The Journal of Pharmacology and Experimental Therapeutics
AbstractThe use of kratom as an alternative to conventional opioids has surged, driven largely by anecdotal reports of its efficacy for pain relief and opioid withdrawal management. The growing prevalence of kratom products enriched with 7-hydroxymitragynine (7-HMG), an active metabolite of mitragynine (MG), necessitates evaluating the respiratory ...
Julio D. Zuarth Gonzalez, Alexandria K. Ragsdale, Sushobhan Mukhopadhyay, Christopher R. McCurdy, Lance R. McMahon, Samuel Obeng, Jenny L. Wilkerson   +6 more
openaire   +1 more source

MOESM2 of In silico investigation of mitragynine and 7-hydroxymitragynine metabolism

, 2019
Additional file 2. Table S1, Figures S1 and S2 for the molecular structures and energies of reaction.
Taweetham Limpanuparb, Rattha Noorat, Yuthana Tantirungrotechai   +2 more
openaire   +1 more source

Multifaceted modulation of human opioid receptors by kratom alkaloids: binding affinity, functional selectivity, and allosteric activity

Frontiers in Pharmacology
IntroductionKratom (Mitragyna speciosa) contains over 50 alkaloids, yet the pharmacological activity of most remains poorly defined, limiting our understanding of its therapeutic potential and safety profile.MethodsWe conducted a comprehensive evaluation
S. E. Hemby, M. Rangel-Grimaldo, S. McIntosh, J. Zheng, L. Flores-Bocanegra, T. N. Graf, R. A. Coover, N. H. Oberlies   +7 more
doaj   +1 more source

Development of transcriptomic resources for interrogating the biosynthesis of monoterpene indole alkaloids in medicinal plant species.

PLoS ONE, 2012
The natural diversity of plant metabolism has long been a source for human medicines. One group of plant-derived compounds, the monoterpene indole alkaloids (MIAs), includes well-documented therapeutic agents used in the treatment of cancer (vinblastine,
Elsa Góngora-Castillo, Kevin L Childs, Greg Fedewa, John P Hamilton, David K Liscombe, Maria Magallanes-Lundback, Kranthi K Mandadi, Ezekiel Nims, Weerawat Runguphan, Brieanne Vaillancourt, Marina Varbanova-Herde, Dean Dellapenna, Thomas D McKnight, Sarah O'Connor, C Robin Buell   +14 more
doaj   +1 more source

Optimizing ultrasound-assisted extraction for enhanced quantification of 7-hydroxymitragynine and mitragynine in kratom

Creative Science
This study focuses on optimizing the extraction of two key alkaloids, mitragynine and 7-hydroxy mitragynine, from kratom (Mitragyna speciosa) leaves using ultrasound-assisted extraction (UAE). The aim was to identify optimal extraction conditions by varying sample-to-liquid ratio, solvent types, methanol concentrations, ultrasonic power, and extraction
Saowapa Chumanee, Jirawan Thunta, Ruchira Khoomsab, Chanakan Winyakul   +3 more
openaire   +1 more source

Kratom (Mitragyna speciosa) in cancer chemoprevention – A provocative functional food perspective

Journal of Agriculture and Food Research
The increasing interest in natural products for cancer prevention has led to a provocative exploration of Kratom (Mitragyna speciosa) as a potential chemopreventive functional food.
Happy Kurnia Permatasari, Dian Nugrahenny, Bayu Lestari, Rani Wardani Hakim, Zulkarnain Zulkarnain, Muhammad Anshory, Fahrul Nurkolis   +6 more
doaj   +1 more source