Results 61 to 70 of about 416 (114)

Evaluation of Interactions Between Transient Receptor Potential Vanilloid 1 and Active Constituents Using Molecular Docking

Dubai Medical Journal
Introduction: Pain, whether acute or chronic, imposes huge economic burdens in the societies due to complexities in the signaling pathways that lead to pain.
Sahar Jaffal, Salman Khan, Muhammad Ibrar Khan   +2 more
doaj   +1 more source

Mitragynine and 7-hydroxymitragynine: In vitro blood-brain barrier permeability studies

Frontiers in Cellular Neuroscience, 2016
Mohd Uzid Mahathir, Hanapi Nur Aziah, Mansor Sharif Mahsufi, Yusof Siti Rafidah   +3 more
openaire   +1 more source

7-Hydroxymitragynine and Nicotine Pouch Withdrawal Syndrome: A Case Report. [PDF]

Cureus
Sharma A, Nair BS, Pemminati S.
europepmc   +1 more source

Genotoxicity risk assessment of a 7-hydroxymitragynine-enriched Kratom preparation: An integrated in silico and in vitro approach. [PDF]

Toxicol Rep
Harnkit N, Sahad T, Noonate I, Primpai P, Radapong S, Pipatrattanaseree W, Sincharoenpokai P, Chamnanpuen P.   +7 more
europepmc   +1 more source

In Silico Assessment of the ADMET Properties of 7-Hydroxymitragynine and its Interaction with Human Serum Albumin and 1-Acid Glycoprotein

Biointerface Research in Applied Chemistry
Mitragyna speciosa (kratom) is a psychoactive plant native to Southeast Asia that is traditionally used for pain relief, increased physical endurance, and as a muscle relaxant. Its most potent alkaloid, 7-hydroxymitragynine (7-OH-MTG), acts on the µ-opioid receptor, providing analgesic effects.
openaire   +1 more source

Translating Kratom-Drug Interactions: From Bedside to Bench and Back. [PDF]

Drug Metab Dispos, 2023
Tanna RS, Cech NB, Oberlies NH, Rettie AE, Thummel KE, Paine MF.   +5 more
europepmc   +1 more source

Nonswallowed Kratom-Derived Products: Unlawful Dietary Supplements That Endanger Public Health. [PDF]

Public Health Rep
White CM, Sedensky A, Belcourt J, Kulkarni P.   +3 more
europepmc   +1 more source

Cardio-pulmonary arrest in a patient revived with naloxone following reported use of 7-hydroxymitragynine

Clinical Toxicology
Mallory K. Pullman, Siva Rama Raju Kanumuri, Juan Francisco Leon, Stephen J. Cutler, Christopher R. McCurdy, Abhisheak Sharma   +5 more
openaire   +1 more source

Mixtures Biotransformation: Multilayer Molecular Networking of Kratom Liver Metabolites. [PDF]

J Nat Prod
Crandall WJ, Weinberg J, Liu K, Lee CM, Singer G, Morgan ET, Jones DP, Quave CL.   +7 more
europepmc   +1 more source

Development and validation of a UPLC-MS/MS method for the determination of 7-hydroxymitragynine, a μ-opioid agonist, in rat plasma and its application to a pharmacokinetic study. [PDF]

Biomed Chromatogr, 2013
Vuppala PK, Jamalapuram S, Furr EB, McCurdy CR, Avery BA.   +4 more
europepmc   +1 more source