Results 1 to 10 of about 1,508,441 (150)

Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish. [PDF]

Nat Commun, 2022
Adenosine deaminases (ADARs) catalyze the deamination of adenosine to inosine, also known as A-to-I editing, in RNA. Although A-to-I editing occurs widely across animals and is well studied, new biological roles are still being discovered. Here, we study
Niescierowicz K, Pryszcz L, Navarrete C, Tralle E, Sulej A, Abu Nahia K, Kasprzyk ME, Misztal K, Pateria A, Pakuła A, Bochtler M, Winata C.   +11 more
europepmc   +2 more sources

Interplay between A-to-I Editing and Splicing of RNA: A Potential Point of Application for Cancer Therapy. [PDF]

Int J Mol Sci, 2022
Adenosine-to-inosine RNA editing is a system of post-transcriptional modification widely distributed in metazoans which is catalyzed by ADAR enzymes and occurs mostly in double-stranded RNA (dsRNA) before splicing.
Goncharov AO, Shender VO, Kuznetsova KG, Kliuchnikova AA, Moshkovskii SA.   +4 more
europepmc   +2 more sources

Divergent landscapes of A-to-I editing in postmortem and living human brain. [PDF]

Nat Commun
Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA modification within the brain. Yet, most research has relied on postmortem samples, assuming it is an accurate representation of RNA biology in the living brain.
Rodriguez de Los Santos M, Kopell BH, Buxbaum Grice A, Ganesh G, Yang A, Amini P, Liharska LE, Vornholt E, Fullard JF, Dong P, Park E, Zipkowitz S, Kaji DA, Thompson RC, Liu D, Park YJ, Cheng E, Ziafat K, Moya E, Fennessy B, Wilkins L, Silk H, Linares LM, Sullivan B, Cohen V, Kota P, Feng C, Johnson JS, Rieder MK, Scarpa J, Nadkarni GN, Wang M, Zhang B, Sklar P, Beckmann ND, Schadt EE, Roussos P, Charney AW, Breen MS.   +38 more
europepmc   +3 more sources

REDIportal: toward an integrated view of the A-to-I editing. [PDF]

Nucleic Acids Res
A-to-I RNA editing is the most common non-transient epitranscriptome modification. It plays several roles in human physiology and has been linked to several disorders.
D'Addabbo P, Cohen-Fultheim R, Twersky I, Fonzino A, Silvestris DA, Prakash A, Mazzacuva PL, Vizcaino JA, Green A, Sweeney B, Yates A, Lussi Y, Luo J, Martin MJ, Eisenberg E, Levanon EY, Pesole G, Picardi E.   +17 more
europepmc   +2 more sources

The A to I editing landscape in melanoma and its relation to clinical outcome [PDF]

RNA Biology, 2022
RNA editing refers to non-transient RNA modifications that occur after transcription and prior to translation by the ribosomes. RNA editing is more widespread in cancer cells than in non-transformed cells and is associated with tumorigenesis of various ...
Austeja Amweg, Marina Tusup, Phil Cheng, Ernesto Picardi, Reinhard Dummer, Mitchell P Levesque, Lars E French, Emmanuella Guenova, Severin Läuchli, Thomas Kundig, Mark Mellett, Steve Pascolo   +11 more
doaj   +2 more sources

Reovirus infection induces transcriptome-wide unique A-to-I editing changes in the murine fibroblasts. [PDF]

Virus Research
The conversion of Adenosine (A) to Inosine (I), by Adenosine Deaminases Acting on RNA or ADARs, is an essential post-transcriptional modification that contributes to proteome diversity and regulation in metazoans including humans.
Ayesha Tariq, Helen Piontkivska
doaj   +2 more sources

The majority of A-to-I RNA editing is not required for mammalian homeostasis

Genome Biology, 2019
Background Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sites across mammalian transcriptomes.
Alistair M. Chalk, Scott Taylor, Jacki E. Heraud-Farlow, Carl R. Walkley   +3 more
doaj   +2 more sources

A to I editing in disease is not fake news. [PDF]

RNA Biol, 2017
Adenosine deaminases acting on RNA (ADARs) are zinc-containing enzymes that deaminate adenosine bases to inosines within dsRNA regions in transcripts. In short, structured dsRNA hairpins individual adenosine bases may be targeted specifically and edited ...
Bajad P, Jantsch MF, Keegan L, O'Connell M.   +3 more
europepmc   +2 more sources

Biological roles of A-to-I editing: implications in innate immunity, cell death, and cancer immunotherapy [PDF]

Journal of Experimental & Clinical Cancer Research, 2023
Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs). Such RNA editing destabilizes endogenous dsRNAs, which are subsequently recognized by the sensors of ...
Jing Yuan, Li Xu, Hai-Juan Bao, Jie-lin Wang, Yang Zhao, Shuo Chen   +5 more
doaj   +2 more sources

Developmental stage-specific A-to-I editing pattern in the postnatal pineal gland of pigs (Sus scrofa) [PDF]

Journal of Animal Science and Biotechnology, 2020
Background RNA editing is a widespread post-transcriptional modification mechanism in mammalian genomes. Although many editing sites have been identified in domestic pigs (Sus scrofa), little is known about the characteristics and dynamic regulation of ...
Rong Zhou, Wenye Yao, Chundi Xie, Leixia Zhang, Yangli Pei, Hua Li, Zheng Feng, Yalan Yang, Kui Li   +8 more
doaj   +2 more sources