Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome [PDF]
Genome Biology, 2017 Background Adenosine to inosine (A-to-I) RNA editing has been shown to be an essential event that plays a significant role in neuronal function, as well as innate immunity, in mammals. It requires a structure that is largely double-stranded for catalysis
Chammiran Daniel +3 more
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Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]
Frontiers in Neuroscience, 2013 The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal responsiveness during development and in maintaining the stability of established networks in the face of altered sensory input.
Andrew Charles Penn +3 more
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The A to I editing landscape in melanoma and its relation to clinical outcome [PDF]
RNA Biology, 2022 RNA editing refers to non-transient RNA modifications that occur after transcription and prior to translation by the ribosomes. RNA editing is more widespread in cancer cells than in non-transformed cells and is associated with tumorigenesis of various ...
Austeja Amweg +11 more
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Reovirus infection induces transcriptome-wide unique A-to-I editing changes in the murine fibroblasts. [PDF]
Virus ResearchThe conversion of Adenosine (A) to Inosine (I), by Adenosine Deaminases Acting on RNA or ADARs, is an essential post-transcriptional modification that contributes to proteome diversity and regulation in metazoans including humans.
Ayesha Tariq, Helen Piontkivska
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Developmental stage-specific A-to-I editing pattern in the postnatal pineal gland of pigs (Sus scrofa) [PDF]
Journal of Animal Science and Biotechnology, 2020 Background RNA editing is a widespread post-transcriptional modification mechanism in mammalian genomes. Although many editing sites have been identified in domestic pigs (Sus scrofa), little is known about the characteristics and dynamic regulation of ...
Rong Zhou +8 more
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Effect of SNORD113-3/ADAR2 on glycolipid metabolism in glioblastoma via A-to-I editing of PHKA2 [PDF]
Cellular & Molecular Biology LettersBackground Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, characterized by its poor prognosis. Glycolipid metabolism is strongly associated with GBM development and malignant behavior.
Zheng Cui +9 more
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Biological roles of A-to-I editing: implications in innate immunity, cell death, and cancer immunotherapy [PDF]
Journal of Experimental & Clinical Cancer Research, 2023 Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs). Such RNA editing destabilizes endogenous dsRNAs, which are subsequently recognized by the sensors of ...
Jing Yuan +5 more
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A-to-I RNA Editing in Cancer: From Evaluating the Editing Level to Exploring the Editing Effects [PDF]
Frontiers in Oncology, 2021 As an important regulatory mechanism at the posttranscriptional level in metazoans, adenosine deaminase acting on RNA (ADAR)-induced A-to-I RNA editing modification of double-stranded RNA has been widely detected and reported.
Heming Wang +9 more
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Advances in A-to-I RNA editing in cancer
Molecular CancerRNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers.
Yi Zhang +9 more
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Knowledge in the Investigation of A-to-I RNA editing signals [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 RNA editing is a post-transcriptional alteration of RNA sequences that is able to affect protein structure as well as RNA and protein expression. A-to-I (Adenosine-to-Inosine) RNA editing is the most frequent and common post-transcriptional modification ...
Giovanni eNigita +4 more
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