Results 111 to 120 of about 2,779,849 (194)

Ocular A-to-I RNA editing signatures associated with SARS-CoV-2 infection

BMC Genomics
Ophthalmic manifestations have recently been observed in acute and post-acute complications of COVID-19 caused by SARS-CoV-2 infection. Our precious study has shown that host RNA editing is linked to RNA viral infection, yet ocular adenosine to inosine ...
Yun-Yun Jin, Ya-Ping Liang, Wen-Hao Huang, Liang Guo, Li-Li Cheng, Tian-Tian Ran, Jin-Ping Yao, Lin Zhu, Jian-Huan Chen   +8 more
doaj   +1 more source

RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal Differentiation in Human Cells. [PDF]

Int J Mol Sci, 2023
Shih CY, Chen YC, Lin HY, Chu CY.
europepmc   +1 more source

Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development. [PDF]

Cell Rep, 2022
Dredge WH, Fan X, Sloofman L, Liang L, Mossotto E, Moore K, Zipkowitz S, Wang M, Zhang B, Wang J, Sestan N, Devlin B, Roeder K, Sanders SJ, Buxbaum JD, Breen MS.   +15 more
europepmc   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology
Deamination of adenosine to inosine (A‐to‐I) in double‐stranded microRNAs (miRNAs) has been demonstrated to affect their function as suppressors or oncogenes in various cancers.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
doaj   +1 more source

ADAR1: a central regulator of dsRNA sensing in host-virus interactions

Frontiers in Immunology
Adenosine deaminase acting on RNA 1 (ADAR1) is a key regulator of RNA homeostasis and innate immunity through its adenosine-to-inosine (A-to-I) editing of double-stranded RNAs (dsRNAs).
Congnuan Liu, Younho Choi
doaj   +1 more source

The A-to-I editing of KPC1 promotes intrahepatic cholangiocarcinoma by attenuating proteasomal processing of NF-κB1 p105 to p50. [PDF]

J Exp Clin Cancer Res, 2022
Gao C, Zhou G, Shi J, Shi P, Jin L, Li Y, Wang X, Liao S, Yan H, Wu J, Lu Y, Zhai Y, Zhang J, Zhang H, Zhang H, Yang C, Cao P, Cheng S, Zhou G.   +18 more
europepmc   +1 more source

Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish. [PDF]

Nat Commun, 2022
Niescierowicz K, Pryszcz L, Navarrete C, Tralle E, Sulej A, Abu Nahia K, Kasprzyk ME, Misztal K, Pateria A, Pakuła A, Bochtler M, Winata C.   +11 more
europepmc   +1 more source

Interplay between A-to-I Editing and Splicing of RNA: A Potential Point of Application for Cancer Therapy. [PDF]

Int J Mol Sci, 2022
Goncharov AO, Shender VO, Kuznetsova KG, Kliuchnikova AA, Moshkovskii SA.   +4 more
europepmc   +1 more source

A-to-I editing: new and old sites, functions and speculations.

Neuron, 2002
Nuclear pre-mRNA editing by selective adenosine deamination (A-to-I editing) occurs in all organisms from C. elegans to humans. This rare posttranscriptional mechanism can alter codons and hence the structure and function of proteins. New findings report new sites, give evidence that the efficiency of editing can be regulated by neurotransmitter, and ...
openaire   +3 more sources

A-to-I RNA edited POLA2 attains carcinogenesis in prostatic cancer by impeding immune infiltration and upregulating BTBD7

Discover Oncology
Background Recently, prostate cancer (PCa) has been increasing in incidence and mortality, which seriously threatens men’s physical and mental health.
Shengyi Lin, Hang Huang, Yeping Li, Yongyong Lu, Tingyu Ye   +4 more
doaj   +1 more source