Results 11 to 20 of about 1,508,590 (281)
Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome [PDF]
Genome Biology, 2017 Background Adenosine to inosine (A-to-I) RNA editing has been shown to be an essential event that plays a significant role in neuronal function, as well as innate immunity, in mammals. It requires a structure that is largely double-stranded for catalysis
Chammiran Daniel +3 more
doaj +5 more sources
The cell line A-to-I RNA editing catalogue [PDF]
Nucleic Acids Research, 2020 Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory ...
Amos A Schaffer +5 more
semanticscholar +4 more sources
Effect of SNORD113-3/ADAR2 on glycolipid metabolism in glioblastoma via A-to-I editing of PHKA2 [PDF]
Cellular & Molecular Biology LettersBackground Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, characterized by its poor prognosis. Glycolipid metabolism is strongly associated with GBM development and malignant behavior.
Zheng Cui +9 more
doaj +2 more sources
Reduced A-to-I editing of endogenous Alu RNAs in lung after SARS-CoV-2 infection1 [PDF]
Current Research in Immunology, 2021 Due to potential severity of disease caused by SARS-CoV-2 infection, it is critical to understand both mechanisms of viral pathogenesis as well as diversity of host responses to infection. Reduced A-to-I editing of endogenous double-stranded RNAs (dsRNAs)
Philip S. Crooke, III +3 more
doaj +2 more sources
De Novo A-to-I RNA Editing Discovery in lncRNA [PDF]
Cancers, 2020 Simple Summary Long non-coding RNAs are emerging as key regulators of gene expression at both transcriptional and translational levels, and their alterations (in expression or sequence) are linked to tumorigenesis and tumor progression.
Domenico A Silvestris +4 more
semanticscholar +4 more sources
A-to-I RNA Editing in Cancer: From Evaluating the Editing Level to Exploring the Editing Effects [PDF]
Frontiers in Oncology, 2021 As an important regulatory mechanism at the posttranscriptional level in metazoans, adenosine deaminase acting on RNA (ADAR)-induced A-to-I RNA editing modification of double-stranded RNA has been widely detected and reported.
Heming Wang +9 more
doaj +3 more sources
Advances in A-to-I RNA editing in cancer
Molecular CancerRNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers.
Yi Zhang +9 more
doaj +3 more sources
LoDEI: a robust and sensitive tool to detect transcriptome-wide differential A-to-I editing in RNA-seq data [PDF]
Nature CommunicationsRNA editing is a highly conserved process. Adenosine deaminase acting on RNA (ADAR) mediated deamination of adenosine (A-to-I editing) is associated with human disease and immune checkpoint control. Functional implications of A-to-I editing are currently
Phillipp Torkler +5 more
doaj +2 more sources
Knowledge in the Investigation of A-to-I RNA editing signals [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 RNA editing is a post-transcriptional alteration of RNA sequences that is able to affect protein structure as well as RNA and protein expression. A-to-I (Adenosine-to-Inosine) RNA editing is the most frequent and common post-transcriptional modification ...
Giovanni eNigita +4 more
doaj +3 more sources
A-to-I editing of the 5HT2C receptor and behaviour. [PDF]
Briefings in Functional Genomics and Proteomics, 2006 Site-specific deamination of five adenosine residues in the pre-mRNA of the serotonin 2C receptor, 5HT2CR, alters the amino acid sequence of the encoded protein. Such RNA editing can produce 32 mRNA variants, encoding 24 protein isoforms that vary in biochemical and pharmacological properties.
K. Gardiner, Yunzhi Du
semanticscholar +3 more sources