Results 11 to 20 of about 2,779,849 (194)

A to I editing in disease is not fake news. [PDF]

RNA Biol, 2017
Adenosine deaminases acting on RNA (ADARs) are zinc-containing enzymes that deaminate adenosine bases to inosines within dsRNA regions in transcripts. In short, structured dsRNA hairpins individual adenosine bases may be targeted specifically and edited with up to one hundred percent efficiency, leading to the production of alternative protein variants.
Bajad P, Jantsch MF, Keegan L, O'Connell M.   +3 more
europepmc   +4 more sources

A-to-I RNA editing: current knowledge sources and computational approaches with special emphasis on non-coding RNA molecules [PDF]

Frontiers in Bioengineering and Biotechnology, 2015
RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Giovanni eNigita, Dario eVeneziano, Alfredo eFerro   +2 more
doaj   +3 more sources

EndoVIA for quantifying A-to-I editing and mapping the subcellular localization of edited transcripts. [PDF]

Methods Enzymol
Adenosine-to-inosine (A-to-I) editing, catalyzed by adenosine deaminases acting on RNA (ADARs), is a prevalent post-transcriptional modification that is vital for numerous biological functions. Given that this modification impacts global gene expression, RNA localization, and innate cellular immunity, dysregulation of A-to-I editing has unsurprisingly ...
Quillin AL, Arnould B, Knutson SD, Flores TF, Heemstra JM.   +4 more
europepmc   +3 more sources

LoDEI: a robust and sensitive tool to detect transcriptome-wide differential A-to-I editing in RNA-seq data [PDF]

Nature Communications
RNA editing is a highly conserved process. Adenosine deaminase acting on RNA (ADAR) mediated deamination of adenosine (A-to-I editing) is associated with human disease and immune checkpoint control. Functional implications of A-to-I editing are currently
Phillipp Torkler, Marina Sauer, Uwe Schwartz, Selim Corbacioglu, Gunhild Sommer, Tilman Heise   +5 more
doaj   +2 more sources

The dynamic epitranscriptome: A to I editing modulates genetic information. [PDF]

Chromosoma, 2016
Adenosine to inosine editing (A to I editing) is a cotranscriptional process that contributes to transcriptome complexity by deamination of adenosines to inosines. Initially, the impact of A to I editing has been described for coding targets in the nervous system. Here, A to I editing leads to recoding and changes of single amino acids since inosine is
Tajaddod M, Jantsch MF, Licht K.
europepmc   +4 more sources

The cell line A-to-I RNA editing catalogue [PDF]

Nucleic Acids Research, 2020
Abstract Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory processes and diseases such as autoimmune and cardiovascular diseases as well
Eli Eisenberg, Erez Y Levanon, Ernesto Picardi, Ayal Hendel, Eli Kopel, Amos A Schaffer   +5 more
openaire   +3 more sources

Substitutional A‐to‐I RNA editing [PDF]

WIREs RNA, 2010
AbstractAdenosine‐to‐inosine (A‐to‐I) editing catalyzed by adenosine deaminases acting on RNA (ADARs) entails the chemical conversion of adenosine residues to inosine residues within double‐stranded RNA (dsRNA) substrates. Inosine base pairs as guanosine and A‐to‐I editing can therefore alter the structure and base pairing properties of the RNA ...
Bjorn-Erik, Wulff, Kazuko, Nishikura
openaire   +2 more sources

Detecting and Characterizing A-To-I microRNA Editing in Cancer [PDF]

Cancers, 2021
Adenosine to inosine (A-to-I) editing consists of an RNA modification where single adenosines along the RNA sequence are converted into inosines. Such a biochemical transformation is catalyzed by enzymes belonging to the family of adenosine deaminases acting on RNA (ADARs) and occurs either co- or post-transcriptionally.
Gioacchino P. Marceca, Luisa Tomasello, Rosario Distefano, Mario Acunzo, Carlo M. Croce, Giovanni Nigita   +5 more
openaire   +2 more sources

An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks

Molecular Cancer, 2021
Background Adenosine deaminases acting on RNA (ADARs) modify many cellular RNAs by catalyzing the conversion of adenosine to inosine (A-to-I), and their deregulation is associated with several cancers.
Julia Ramírez-Moya, Christos Miliotis, Allison R. Baker, Richard I. Gregory, Frank J. Slack, Pilar Santisteban   +5 more
doaj   +1 more source

The Many Roles of A-to-I RNA Editing in Animals: Functional or Adaptive?

Frontiers in Bioscience-Landmark, 2023
Metazoan adenosine-to-inosine (A-to-I) RNA editing is a highly conserved mechanism that diversifies the transcriptome by post-transcriptionally converting adenosine to inosine.
Dongwu Zhan, Caiqing Zheng, Wanzhi Cai, Hu Li, Yuange Duan   +4 more
doaj   +1 more source