Results 221 to 230 of about 515,927 (320)

Plasma‐Treated Hydrogel for Combined RONS and Chemotherapy Delivery: A Proof‐of‐Concept In Ovo

Advanced Functional Materials, EarlyView.
This study explores plasma‐treated hydrogels (PTH) as a new way to deliver both reactive oxygen and nitrogen species and chemotherapy (Doxorubicin) directly to tumors. In ovo tests show effects after a single dose, especially in osteosarcoma tumors. Tumor weight decrease, and a resistance‐related protein is reduced.
Milica Živanić, Albert Espona‐Noguera, Angela Privat Maldonado, Patrik Matušů, Francesco Tampieri, Maria‐Pau Ginebra, Abraham Lin, Evelien Smits, Annemie Bogaerts, Cristina Canal   +9 more
wiley   +1 more source

Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites. [PDF]

Fly (Austin)
Duan Y, Ma L, Zhao T, Liu J, Zheng C, Song F, Tian L, Cai W, Li H.   +8 more
europepmc   +1 more source

Eco‐Fabricated Nanowave‐Textured Implants Drive Microtubule‐Assisted Nuclear Mechanotransduction and Chromatin Modification: Biophysical Priming for Osteogenesis and Bone Regeneration

Advanced Functional Materials, EarlyView.
Eco‐friendly nanowave‐textured implants produced via femtosecond laser fabrication enhance bone regeneration by orchestrating a precise mechanotransduction cascade. This nanotopography directs mesenchymal stem cell alignment and cytoskeletal organization, triggering changes in nuclear shape and chromatin acetylation that prime cells for osteogenesis ...
Bosu Jeong, Ji‐Young Yoon, Junyong Ahn, Byunghak Lee, Sung‐Min Park, Jae‐Heon Kim, Buuvee Bayarkhangai, Yu Jin Kim, Sak Lee, Jonathan C. Knowles, Moon‐Young Kim, DongJun Lee, Sang‐Hoon Rhee, Hae‐Hyoung Lee, Hae‐Won Kim, Jung‐Hwan Lee   +15 more
wiley   +1 more source

ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit. [PDF]

Proc Natl Acad Sci U S A, 2022
Riella CV, McNulty M, Ribas GT, Tattersfield CF, Perez-Gill C, Eichinger F, Kelly J, Chun J, Subramanian B, Guizelini D, Nephrotic Syndrome Study Network (NEPTUNE), Alper SL, Pollak MR, Sampson MG, Friedman DJ.   +14 more
europepmc   +1 more source

Supervariate Gel Transforms into Various Biominerals in Salt Solutions

Advanced Functional Materials, EarlyView.
It is revealed that common calcium‐based biominerals can form from a stable, non‐toxic ‘supervariate’ gel. This tunable gel selectively yields calcite or hydroxyapatite in carbonate/phosphate solutions, while CaCl₂ facilitates the formation of dihydrate calcium pyrophosphate, which converts to hydroxyapatite upon drying. These findings provide insights
Xinxue Tang, Chong Wang, Yuk‐Tong Cheng, Junda Shen, Yunchen Long, Hongkun Li, Jie Yan, Yang Ren, Xiao Ma, Yufeng Huang, Zhengtao Xu, Jian Lu, Yang Yang Li   +12 more
wiley   +1 more source

Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene. [PDF]

Epigenetics
Zheng C, Ma L, Song F, Tian L, Cai W, Li H, Duan Y.   +6 more
europepmc   +1 more source

GPEdit: the genetic and pharmacogenomic landscape of A-to-I RNA editing in cancers. [PDF]

Nucleic Acids Res, 2022
Ruan H, Li Q, Liu Y, Liu Y, Lussier C, Diao L, Han L.   +6 more
europepmc   +1 more source

Excessive production and extreme editing of human metapneumovirus defective interfering RNA is associated with type I IFN induction

, 2014
Bernadette G. van den Hoogen, Sander van Boheemen, Jonneke de Rijck, Stefan van Nieuwkoop, Derek J. Smith, Brigitta M. Laksono, Alexander P. Gultyaev, Albert D. M. E. Osterhaus, Ron A. M. Fouchier   +8 more
openalex   +1 more source

Direct Immunodetection of Global A‐to‐I RNA Editing Activity with a Chemiluminescent Bioassay

, 2021
Steve D. Knutson, Robert A. Arthur, H. Richard Johnston, Jennifer M. Heemstra   +3 more
openalex   +2 more sources

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source