Results 161 to 170 of about 83,344 (312)

Elucidation of the molecular mechanisms of biased agonism at the adenosine A1 receptor

, 2021
Samantha M. McNeill
openalex   +2 more sources

Astrocyte Regulation of Spinal Circuit Function

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff, Min Jun Li, Axel Nimmerjahn   +2 more
wiley   +1 more source

Differential desensitization of A1 adenosine receptor-mediated inhibition of cardiac myocyte contractility and adenylate cyclase activity. Relation to the regulation of receptor affinity and density. [PDF]

, 1990
Bruce T. Liang, Lucy Donovan
openalex   +1 more source

CYP1A2 Genotype and the Ergogenic Effect of Acute Caffeine Intake on Muscular Strength and Endurance Performance in Trained Individuals

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 2, February 2026.
ABSTRACT This study examined whether CYP1A2 (rs762551) genotype modulates the acute ergogenic effects of caffeine on muscular strength and endurance performance in resistance‐trained men and women. Ninety‐four resistance‐trained participants (47 females, 47 males; 39 AA, 44 AC, 11 CC) completed a randomized, triple‐blind, placebo‐controlled, crossover ...
Juan Jesús Montalvo‐Alonso, Marta del Val‐Manzano, Iván Martín‐Rivas, Carmen Ferragut, David Valadés, Alberto Pérez‐López   +5 more
wiley   +1 more source

Molecular mechanisms of plant NLR activation and signalling

The Plant Journal, Volume 125, Issue 3, February 2026.
SUMMARY Plants rely on NLRs (nucleotide‐binding leucine‐rich repeat receptors) to recognise effector proteins secreted by pathogens into plant cells and to deliver disease resistance. Plant NLRs are broadly characterised by their N‐terminal domains, which include the TIR (Toll/interleukin‐1 receptor) and the CC (coiled‐coil) domains.
Natsumi Maruta, Mitchell Sorbello, Laura Garzon‐Flores, Bostjan Kobe   +3 more
wiley   +1 more source

The A1 adenosine receptor. Solubilization and characterization of a guanine nucleotide-sensitive form of the receptor.

, 1985
Gary L. Stiles
openalex   +1 more source

109 COORDINATE REGULATION OF A1 AND A2 ADENOSINE RECEPTOR IN CULTURED NEUROBLASTOMA AND LYMPHOBLASTOID CELLS [PDF]

, 1988
Roberta M. Palmour, A.-M. Babey, Aaron Smith   +2 more
openalex   +1 more source

Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells.

Proceedings of the National Academy of Sciences of the United States of America, 2004
S. Briddon, Richard J. Middleton, Y. Cordeaux, F. Flavin, Julia A. Weinstein, Michael W. George, B. Kellam, Stephen J. Hill   +7 more
semanticscholar   +1 more source

Structure-based discovery of positive allosteric modulators of the A₁ adenosine receptor. [PDF]

Proc Natl Acad Sci U S A
Nguyen ATN, Panel N, Vo DD, Thai BS, Chia LY, Lu CS, Hellyer SD, Langiu M, Jörg M, Gregory KJ, Kihlberg J, White PJ, Scammells PJ, Christopoulos A, Carlsson J, May LT.   +15 more
europepmc   +1 more source

Manipulation of the Unfolded Protein Response by Intracellular Bacterial Pathogens: Mechanisms of ER Hijacking and Therapeutic Implications

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This review illustrates how intracellular bacterial pathogens—such as Brucella, Mycobacterium tuberculosis, and Legionella—secrete effector proteins that specifically target the IRE1α, PERK, and ATF6 branches of the unfolded protein response (UPR) to hijack ER stress signaling.
Enhui Dai, Dongjie Sun, Yanxiao Zhao, Mengtao Zhang, Yifan Wu, Jiabo Ding   +5 more
wiley   +1 more source