Results 211 to 220 of about 26,813 (237)

Irinotecan and temozolomide brain distribution: a focus on ABCB1

Cancer Chemotherapy and Pharmacology, 2014
Glioblastoma (GBM), the most common primary brain tumor in adults, is usually rapidly fatal with median survival duration of only 15 months and a 3-year survival rate of
Lauriane, Goldwirt, Kevin, Beccaria, Alexandre, Carpentier, Robert, Farinotti, Christine, Fernandez   +4 more
openaire   +2 more sources

The influence of ABCB1 polymorphism C3435T on the pharmacokinetics of silibinin

Journal of Clinical Pharmacy and Therapeutics, 2015
Silibinin (Silybin), a major constituent of the milk thistle, is commonly used to treat chronic liver disease in some countries. It has been reported to inhibit the transport activity of ABCB1. This study was carried out to determine whether ABCB1 C3435T polymorphism influenced the pharmacokinetics of silibinin contained in silymarin capsules.Twenty ...
Z R, Tan, Y X, Zhou, J, Liu, W H, Huang, Y, Chen, Y C, Wang, L S, Wang   +6 more
openaire   +2 more sources

Promoter polymorphisms and allelic imbalance in ABCB1 expression

Pharmacogenetics and Genomics, 2007
The ABCB1 (MDR1) gene, encoding the transporter P-glycoprotein, is known to act on a broad range of prescription medicines. For this reason a large number of studies have assessed the functional consequences of variation in this gene. Particular attention has focused on the ABCB1_3435C>T polymorphism, an exonic variant resulting in a synonymous change.
Loeuillet, C, Weale, M, Deutsch, S, Rotger, M, Soranzo, N, Wyniger, J, Lettre, G, Dupre, Y, Thuillard, D, Beckmann, JS, Antonarakis, SE, Goldstein, DB, Telenti, A   +12 more
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Clinical Aspects of the MDR1 (ABCB1) Gene Polymorphism

Therapeutic Drug Monitoring, 2004
Transporter proteins, in particular P-glycoprotein (Pgp), are important determinants in absorption, tissue targeting, and elimination of drugs. In addition to physiological and environmental factors, its expression and function are modified by genetic polymorphisms of the MDR1 gene.
Michel, Eichelbaum, Martin F, Fromm, Matthias, Schwab   +2 more
openaire   +2 more sources

Association of a polymorphism in the ABCB1 gene with Parkinson's disease

Parkinsonism & Related Disorders, 2009
The ATP-binding cassette, sub-family B, member 1 (ABCB1) gene encoding the protein P-glycoprotein (P-gp) has been implicated in the pathophysiology of Parkinson's disease (PD) due to its role in regulating transport of endogenous molecules and exogenous toxins.
Marie, Westerlund, Andrea Carmine, Belin, Anna, Anvret, Anna, Håkansson, Hans, Nissbrandt, Charlotta, Lind, Olof, Sydow, Lars, Olson, Dagmar, Galter   +8 more
openaire   +2 more sources

ABCB1 single nucleotide polymorphisms in the Brazilian population

Molecular Biology Reports, 2009
The ABCB1/MDR-1 gene, which encodes P-glycoprotein, is highly polymorphic. We analyzed 278 healthy Brazilian individuals through PCR-RFLP to identify ABCB1 variants and determine the genotypic and allelic frequencies. Genotypic frequencies for C1236T (rs1128503) were 0.31 for CC, 0.60 for CT and 0.09 for TT and allelic frequencies were 0.61 and 0.39 ...
Marcos Antonio Mauricio, Scheiner, Arthur Motta, Damasceno, Raquel Ciuvalschi, Maia   +2 more
openaire   +2 more sources

Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1

Proceedings of the National Academy of Sciences of the United States of America, 2020
Kamil Nosol, Ksenija Romane, Rossitza N Irobalieva   +2 more
exaly  

Role of ABCB1 C3435T in Platinum-based Therapy

Archives of Medical Research, 2012
P. Pellegrino, D. Cattaneo, E. Clementi
openaire   +2 more sources

No Influence of ABCB1 Haplotypes on Methadone Dosage Requirement

Clinical Pharmacology & Therapeutics, 2008
Crettol, S, Déglon, J.J., Besson, J, Croquette-Krokar, M, Hämmig, Robert, Gothuey, I, Monnat, M, Eap, C.B.   +7 more
openaire   +3 more sources

ABCB1

2006
openaire   +1 more source