Results 201 to 210 of about 26,813 (237)

Functioning of ABCB1 protein in pregnancy

Voprosy ginekologii, akušerstva i perinatologii, 2023
Objective. To study the functioning of ABCB1 protein in pregnancy, namely, to evaluate its amount in the organs that play a significant role in pharmacokinetics and its functional activity at the whole organism level. Materials and methods. The study was performed on 52 female rabbits divided into two groups.
N.M. Popova, A.V. Shchulkin, P.Yu. Mylnikov, I.V. Chernykh, E.N. Yakusheva   +4 more
openaire   +1 more source

Clinical Significance of ABCB1 in Acute Myeloid Leukemia: A Comprehensive Study

Cancers, 2019
ABCB1 is a member of the ATP binding cassette transporter family and high ABCB1 activity is considered as a poor prognostic factor in acute myeloid leukemia (AML) treated with intensive chemotherapy, its direct relation with drug resistance remains ...
Thomas Boyer, Adeline Barthelemy, Pauline Peyrouze   +2 more
exaly   +2 more sources

ABCB1 Pharmacogenetics: Progress, Pitfalls, and Promise

Clinical Pharmacology & Therapeutics, 2007
In 1976, Juliano and Ling(1) reported expression of a 170 kDa protein in colchicine-resistant Chinese hamster ovary (CHO) cells that was absent in drug-sensitive cells. Because this protein altered cellular permeability to colchicine, the authors named it P-glycoprotein (P-gp).(1) P-gp overexpression was described in tumor samples and leukemic cells.(2)
L W, Chinn, D L, Kroetz
openaire   +2 more sources

ABCB1

pharma-kritik, 2017
Mit der Genotypisierung des ABCB1-Gens – das das P-Glykoprotein enkodiert – soll eine wirksamere Antidepressiva-Therapie möglich sein. Bisher ist ungenügend dokumentiert, dass dies der Fall ist.    
openaire   +1 more source

Genuine Functions of P-Glycoprotein (ABCB1)

Current Drug Metabolism, 2008
P-glycoprotein (P-gp, ABCB1, MDR1) was recognized as a drug-exporting protein from cancer cells three decade ago. Apart from the multidrug transporter side effects of P-gp, normal physiological functions of P-gp have been reported. P-gp could be responsible for translocating platelet-activating factor (PAF) across the plasma membrane and PAF inhibited ...
Takaharu, Mizutani, Masatoshi, Masuda, Emi, Nakai, Kenji, Furumiya, Hiroshi, Togawa, Yutaka, Nakamura, Yuko, Kawai, Keiko, Nakahira, Shigeko, Shinkai, Kazuhiko, Takahashi   +9 more
openaire   +2 more sources

Genomics and the mechanism of P-glycoprotein (ABCB1)

Journal of Bioenergetics and Biomembranes, 2007
The development of effective clinical interventions against multidrug resistance (MDR) in cancer remains a significant challenge. Single nucleotide polymorphisms (SNPs) contribute to wide variations in how individuals respond to medications and there are several SNPs in human P-glycoprotein (P-gp) that may influence the interactions of drug-substrates ...
Zuben E, Sauna, In-Wha, Kim, Suresh V, Ambudkar   +2 more
openaire   +2 more sources

Breed distribution of the ABCB1-1Δ (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping

Journal of the American Veterinary Medical Association, 2008
Abstract Objective—To evaluate the breed distribution of the ABCB1-1Δ polymorphism in a large number of dogs in North America, including dogs of several herding breeds in which this polymorphism has been detected and other breeds in which this polymorphism has not yet been identified. Design—Cross-sectional study.
Katrina L, Mealey, Kathryn M, Meurs
openaire   +2 more sources

ABCB1 and Cytochrome P450 Polymorphisms

Journal of Clinical Psychopharmacology, 2009
To examine the genetic factors influencing clozapine kinetics in vivo, 75 patients treated with clozapine were genotyped for CYPs and ABCB1 polymorphisms and phenotyped for CYP1A2 and CYP3A activity. CYP1A2 activity and dose-corrected trough steady-state plasma concentrations of clozapine correlated significantly (r = -0.61; P = 1 x 10), with no ...
Jaquenoud Sirot, Eveline, Knezevic, Branka, Morena, Gina Perla, Harenberg, Sabine, Oneda, Beatrice, Crettol, Severine, Ansermot, Nicolas, Baumann, Pierre, Eap, Chin B   +8 more
openaire   +3 more sources

Genetic modulation of ABCB1: Sunvozertinib reverses ABCB1-mediated multidrug resistance in cancer cells

Cancer Genetics
Sunvozertinib is an oral, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) designed to treat non-small cell lung cancer (NSCLC) patients with EGFR exon 20 insertion mutations under a phase II clinical trial. In this study, we investigated whether sunvozertinib could antagonize ABCB1, also known as multidrug ...
Lu-Qi Cao, Yuhao Xie, Xuanyu Chen, Harsh Patel, Luoxi Yuan, John Wurpel, Kunxiang Gong, Zhe-Sheng Chen   +7 more
openaire   +2 more sources

The potentiation of menadione on imatinib by downregulation of ABCB1 expression

Clinical and Experimental Pharmacology and Physiology, 2020
Abstract Imatinib was the first BCR‐ABL inhibitor used in clinical practice to treat chronic myeloid leukaemia (CML) and significantly improve the life expectancy of CML patients in the chronic phase. However, a portion of CML patients are resistant to imatinib.
Fei‐Yan Xiao, Fang‐Jiao Zhou, Fang Yuan, Wei Kuang, Gan Zhou, Hong‐Hao Zhou, Shan Cao   +6 more
openaire   +2 more sources